A Study to Investigate the Improvement of Photosensitivity in Terms of Skin Lesions Associated With CEP Following Administration of Oral ATL-001 (Ciclopirox Oral Solution) in Participants Aged >18 Years of Age With CEP

Официальное название

A Phase I-II, N-of-1, Open-Label, Prospective Study to Evaluate the Efficacy and Safety of ATL-001 in Adult Patients With Congenital Erythropoietic Porphyria (CEP)

Обзор

This is a study to investigate the effect of oral ATL-001 (ciclopirox) in CEP (Congenital Erythropoietic Porphyria) patients. During the study, it will be measured the improvement of skin lesions, fatigue and other clinical symptoms as well as blood parameters. Funding source - FDA OOPD

Вмешательства

• Препарат ATL-001 (Ciclopirox oral solution)
  Daily administration of oral ATL-001

Первичные конечные точки

• To evaluate the efficacy of ATL-001 in patients with CEP in terms of change in lesions associated with photosensitivity. [Срок оценки: From Baseline to 12 weeks intervals until the end of study (48 weeks)]

Критерии участия

Критерии включения

• Aged 18 years or older at the time of signing the informed consent form (ICF)
• Diagnosis of CEP, based on medical history and/or biochemical porphyrin analysis. Sponsor will review the CEP diagnostic criteria (medical history or biochemical porphyrin analysis) of each potential patient, written Sponsor approval before starting the run-in period will be required
• a) Female participants must not be pregnant or lactating at screening or admission

3\. b) Female participants must be of nonchildbearing potential or agree to use 2 adequate forms of highly effective method(s) of contraception throughout the entire duration of study participation and for at least 4 weeks after the last dose of any study intervention and have negative pregnancy test results at screening (serum) and admission (urine) 4. Male participants with female partners of childbearing potential must be surgically sterile (successful vasectomy at least 4 weeks prior to Day 1) or agree to use adequate forms of highly effective contraception (together with their female partner) for the duration of the study and for at least 4 weeks after the last dose of study intervention; must also agree to refrain from sperm donation during the study and for at least 4 weeks after the last dose of study intervention 5. Negative pregnancy test (females of childbearing potential) at Screening (Month -6), at Baseline (Day 1) and at every visit site until EoS prior to dosing 6. Able to understand the study aims, procedures, and requirements, and provide written informed consent 7. Able to comply with all study procedures 8. Able and committed to complete study patient diaries and questionnaires

Критерии исключения

• Other than CEP, an inherited or acquired red cell disease associated with anemia
• Any other photodermatosis such as solar urticaria
• A history or known allergic reaction to any investigational product excipients or the investigational drug
• Major surgery within 8 weeks before Screening, incomplete recovery from any previous surgery or planned major surgery during the study
• History of alcohol dependence or excessive alcohol consumption, as assessed by the Investigator
• Human immunodeficiency virus (HIV), active Hepatitis B, or C. A positive hepatitis result should be discussed between the Investigator and Sponsor prior to enrolment
• Score of Personal Health Questionnaire Depression Scale (PHQ-8) ≥10 at screening or any response of "yes" on the Columbia-Suicide Severity Rating Scale (C-SSRS)
• Uncontrolled medical condition or concomitant medication that would confound the ability to interpret clinical, clinical laboratory, or participant diary data, including a major psychiatric condition that has had an exacerbation or required hospitalization in the last 6 months
• Administration of afamelanotide and dersimelagon within the last 2 months prior to start of the run-in period
• Total bilirubin >2× ULN (unless documented Gilbert syndrome) at Screening
• If female, pregnant or breastfeeding. Final\_V2.1 38 of 106 11 Apr 2025
• Participation in any other clinical protocol or investigational trial that involves administration of experimental therapy and/or therapeutic devices within 30 days of Screening.

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Нет

Дизайн исследования

Распределение

Не применимо

Модель

Одна группа

Маскирование

Открытое

Основная цель

Лечение

Центры проведения

США · 1 центр

• The Cleveland Clinics — Cleveland

Идентификаторы

NCT: NCT07024316 · ATL001-PII-CEP · 1R01FD008540-01

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

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