CDK4/6 Inhibitors Combined With Standard Adjuvant Endocrine Therapy in High-Risk, HR+/HER2+ Early Breast Cancer Patients(CHESS)

Официальное название

A Study on the Efficacy and Safety of CDK4/6 Inhibitors Combined With Standard Adjuvant Endocrine Therapy in High-Risk, HR+/HER2+ Early Breast Cancer Patients Who Have Completed Adjuvant Anti-HER2 Targeted Therapy"

Обзор

This study is a prospective, open-label, multicenter, randomized controlled Phase III clinical trial. Building upon anti-HER2 targeted therapy combined with endocrine therapy, the addition of CDK4/6 inhibitors has demonstrated greater clinical benefits for advanced TPBC patients. This study aims to investigate the efficacy and safety of CDK4/6 inhibitor combination with standard adjuvant endocrine therapy in HR+/HER2+ early breast cancer patients.

Вмешательства

• Препарат Endocrine Therapy (Tamoxifen, Anastrozol, Letrozole, Exemestane)
  Standard endocrine therapy
• Препарат Standard endocrine therapy combined with CDK4/6 Inhibitor
  CDK4/6 inhibitor therapy for 2 years in combination with standard endocrine therapy

Первичные конечные точки

• 5-years Invasive disease free survival [Срок оценки: 5 years]

Вторичные конечные точки (4)

• Distant Recurrence-Free Survival (DRFS) [Срок оценки: 5 years]
• Overall Survival (OS) [Срок оценки: Approximately 5 years]
• Safety including adverse events (AEs), severe adverse events (SAEs) and adverse events of special interest (AESI). [Срок оценки: Up to approximately 3 years]
• Patient-Reported Outcome (PRO) [Срок оценки: Up to approximately 3 years]

Критерии участия

Критерии включения

• Females aged ≥18 and ≤70 years.
• ECOG systemic status grade 0 to 1.
• Histologically confirmed invasive HR+/HER2+ breast cancer (Specific definition: breast cancer patients whose estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER-2) are all determined to be positive by pathologic testing. Specifically: ER positive: IHC>10%, PR positive: IHC>10%, HER2 positive: IHC+++ or IHC++ but amplified by FISH.
• Early-stage breast cancer after radical mastectomy with postoperative pathology consistent with TNM staging of ≥pN1 ; or postoperative pathology suggestive of non-pCR after neoadjuvant therapy; or postoperative pathology suggestive of pCR after neoadjuvant therapy but with clinical staging consistent with cT4 or N3 before neoadjuvant therapy
• Within 1 year of completion of adjuvant anti-HER2 targeted therapy: anti-HER2 targeted therapy includes trastuzumab-based therapy, and/or T-DM1 therapy, and/or TKI therapy.
• The function of major organs is basically normal, and the following conditions are met: ① The criteria for routine blood tests need to be met: HB ≥ 90g/L (no blood transfusion within 14 days); ANC ≥ 1.5 × 109/L; PLT ≥ 75 × 109/L; ② The biochemical tests need to be met as follows: TBIL ≤ 1.5 × ULN (the upper limit of normal value); ALT and AST ≤ 3 × ULN; serum Cr ≤ 1 × ULN, and endogenous creatinine clearance > 50 ml/min (Cockcroft-Gault formula).
• Female subjects of childbearing potential are required to use a medically approved form of contraception during study treatment, and for at least 3 months after the last dose of study drug.
• Subjects voluntarily enrolled in the study, signed an informed consent form, were compliant, and cooperated with follow-up visits.

Критерии исключения

• Bilateral breast cancer;
• Metastasis to any site;
• Taking food or medications that are strong inhibitors or inducers of CYP3/4.

• Strong inhibitors of CYP3/4 include: boceprevir, clarithromycin, konifactam, delavirdine, indinavir, itraconazole, ketoconazole, ritonavir, mibefradil, miconazole, fazodone, nelfinavir, propoxiconazole, ritonavir, saquinavir, naloxone, telaprevir, telithromycin, voriconazole, grapefruit, grapefruit juice, or grapefruit containing foods.
• Strong inducers of CYP3/4 including carbamazepine, phenytoin, pramipexole, rifampin, and St. John's wort.
• History of clinically significant or uncontrolled cardiac disease including congestive heart failure, angina pectoris, myocardial infarction within the last 6 months, or ventricular arrhythmia;
• other malignancy within the previous 5 years, excluding cured carcinoma in situ of the cervix, basal cell carcinoma of the skin, or squamous cell carcinoma of the skin;
• Pregnant or lactating women, women of childbearing age who are unable to use effective contraception;
• Patients who are concurrently enrolled in other clinical trials;
• severe or uncontrolled infection;
• Patients with known active HBV or HCV infection or Hepatitis B DNA ≥500, or chronic stage with abnormal liver function;
• Those with a history of psychotropic substance abuse that cannot be stopped or those with psychiatric disorders;
• Patients who, in the judgment of the investigator, are not suitable for participation in this study.

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Нет

Дизайн исследования

Распределение

Рандомизированное

Модель

Параллельные группы

Маскирование

Открытое

Основная цель

Лечение

Центры проведения

Китай · 1 центр

• Fudan cancer center — Шанхай

Идентификаторы

NCT: NCT07019363 · SCHBCC-N091

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

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