Role of Inferior Colliculi in Auditory Hallucinations

Официальное название

Rôle Des Colliculi inférieurs Dans Les Hallucinations Auditives : étude Pilote Par Neuroimagerie

Обзор

The neural basis of auditory hallucinations (AH) in patients with schizophrenia is poorly characterized. Functional imaging studies investigate either the "state" dimension (i.e., the measurement of changes in brain area activation at the precise moment of AH onset) or the "trait" dimension (i.e., the neural correlates of the propensity to hallucinate). A corollary of AH (particularly acoustic-verbal) is the activation of brain regions involved in the auditory perception of speech (auditory cortex). One theory is that patients with schizophrenia with AH may have a deficit in processing their internal speech (i.e., external attribution to internal verbal content). However, there is little clinical data on the specific role of the mesencephalic region of the inferior colliculi (IC) in the formation of these symptoms. Preliminary research has shown intense expression of dopamine D2 receptors, particularly on glutamatergic neurons in mouse ICs. Thus, ICs receive numerous inhibitory dopaminergic inputs, likely involved in signal optimization and modulation. The study authors hypothesize that AHs are the result of a defect in signal inhibition by the IC, which lose their function as perceptual filters.

Вмешательства

• Другое Unenhanced brain MRI
  Unenhanced brain MRI in five sequences: 1) T1-weighted anatomical sequences 2) Resting-state functional sequences 3) Task-based functional sequence 4) Structural sequence using Diffusion Tensor Imaging (DTI) 5) Routine magnetic resonance spectroscopy sequence

Первичные конечные точки

• Resting state of functional connectivity of the inferior colliculi region with other regions of the auditory network between groups [Срок оценки: Day 0]
• Default mode network patterns between groups [Срок оценки: Day 0]

Вторичные конечные точки (11)

• Neuronal activation in the ICs during exposure to auditory stimuli between groups [Срок оценки: Day 0]
• Per-auditory activation in other brain areas between groups [Срок оценки: Day 0]
• IC metabolite composition between the groups [Срок оценки: Day 0]
• Structural connectivity via white matter between ICs and other auditory network structures between groups [Срок оценки: Day 0]
• Correlation between BOLD signal and psychopathological symptoms [Срок оценки: Day 0]
• Correlation between BOLD signal and severity of delusions and hallucinations [Срок оценки: Day 0]
• Correlation between BOLD signal and doses of antipsychotic treatment [Срок оценки: Day 0]
• Difference in perauditory activation and functional connectivity (resting-state) in SCZ+ HA+ patients who hallucinated during the procedure and those who did not [Срок оценки: Day 0]
• Correlation between BOLD signal and dissociation symptoms [Срок оценки: Day 0]
• Correlation between BOLD signal and severity of somatoform manifestations of dissociation [Срок оценки: Day 0]
• Correlation between BOLD signal and clinically assessed states of dissociation [Срок оценки: Day 0]

Критерии участия

Критерии включения

• The patient must have given their free and informed consent and signed the consent form
• The patient must be a member or beneficiary of a health insurance plan
• DSM-5 diagnosis of schizophrenic disorder (based on clinical assessment and confirmed by the MINI 7.0 interview)
• Patient with a schizophrenic disorder lasting ≤ 20 years
• Patient treated in a psychiatric unit as an inpatient (in non-specialized care) or outpatient or under a mandatory ambulatory psychiatric care programme
• Clinical condition compatible with imaging based on clinical judgment
• Ability to understand, write, and read French

Specific inclusion criteria for the group (SCZ+/HA+) • Patient with a PANSS score (question P3 regarding hallucinations) ≥ 4 (corresponds to PANSS (P3) 4, 5, 6, and 7 patients) AND having experienced hallucinations in the past 15 days.

Specific inclusion criteria for the control group

• Patient with a PANSS score (question P3 regarding hallucinations) = 1) AND having not experienced any hallucinations in the past 15 days.

Критерии исключения

• The patient is under safeguard of justice or state guardianship
• Contraindications to magnetic resonance imaging, including severe claustrophobia, based on clinical judgment.
• Congenital or acquired deafness
• Suicide risk, based on clinical judgment
• Patient with moderate to severe intellectual disability, based on medical records
• Patient with moderate to severe neurocognitive disorders, based on medical records
• Patient receiving anticholinergic therapy (biperiden-Akineton, trihexyphenidyl-Artane, tropatepine-Lepticur)
• Patient participating in an interventional study involving a drug or medical device, or a Category 1 RIPH within 3 months prior to inclusion
• Person under judicial protection
• Pregnant, parturient, or breastfeeding woman
• Person unable to express consent

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Нет

Дизайн исследования

Распределение

Нерандомизированное

Модель

Параллельные группы

Маскирование

Открытое

Основная цель

Другое

Центры проведения

Франция · 1 центр

• CHU de Nîmes, Hôpital Universitaire Carémeau — Nîmes

Идентификаторы

NCT: NCT07003529 · NIMAO2024-2/MP-01

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

Открыть это исследование на ClinicalTrials.gov ↗