Limertinib Plus Carboplatin and Etoposide for EGFR-mutant NSCLC With SCLC Transformation After EGFR-TKI Progression

Официальное название

A Single-center, Single-arm Phase II Study of Limertinib Plus Carboplatin and Etoposide in EGFR-mutant NSCLC Patients With SCLC Transformation After EGFR-TKI Progression

Обзор

This single-center, prospective study and aims to evaluate the efficacy and safety of limertinib combined with etoposide and carboplatin in EGFR-mutant NSCLC patients who develop small-cell lung cancer transformation following progression on EGFR-TKI therapy.

Подробное описание

This is a single-center, prospective interventional Phase II study designed to assess the efficacy, safety and mechanism of resistance to limertinib combined with carboplatin and etoposide in EGFR-mutant NSCLC patients who have histologically confirmed small-cell transformation after progression on EGFR-TKI therapy. Thirty patients will receive Limertinib orally once daily (80 mg) plus carboplatin (AUC 5-6, day 1) and etoposide (100 mg/m², days 1-3) every 21 days until disease progression or unacceptable toxicity. Radiographic tumor evaluation will be conducted every 6 weeks per RECIST v1.1. Tumor tissue and blood specimens will be collected at baseline and upon disease progression for next-generation sequencing to elucidate the molecular mechanisms underlying histological transformation.

Вмешательства

• Препарат limertinib
  limertinib 80 mg
• Препарат etoposide and carboplatin
  etoposide 100 mg/m² IV D1-3 + carboplatin AUC 5-6 IV

Первичные конечные точки

• Progression-free survival (PFS) [Срок оценки: Time from first subject dose to study completion, or up to 36 month]

Вторичные конечные точки (4)

• Objective Response Rate (ORR) [Срок оценки: Time from first subject dose to study completion, or up to 36 month]
• Disease control response (DcR) [Срок оценки: Time from first subject dose to study completion, or up to 36 month]
• Duration of Response (DoR) [Срок оценки: Time from first subject dose to study completion, or up to 36 month]
• Adverse events (AEs) [Срок оценки: From first dose to the last dose, up to 24 month]

Критерии участия

Критерии включения

• Patients must meet all of the following to be eligible for enrollment:
• Signed written informed consent prior to any study-related procedures.
• Age ≥ 18 and ≤ 80 years.
• Histologically or cytologically confirmed non-small cell lung cancer (NSCLC) with a sensitizing EGFR mutation (exon 19 deletion or L858R, with or without concurrent mutations).
• Prior treatment with EGFR-TKI, with documented disease progression and histologically confirmed small-cell lung cancer (SCLC) transformation.
• At least one measurable target lesion per RECIST v1.1.
• ECOG performance status 0-1 (see Appendix for ECOG scale).
• Estimated life expectancy > 3 months.
• Adequate bone marrow function, defined as:
• ANC ≥ 1,500/mm³
• Hemoglobin ≥ 9 g/dL
• Platelets ≥ 90,000/mm³
• Adequate hepatic function, defined as:
• Total bilirubin ≤ 1.5 × ULN
• AST and ALT ≤ 2.5 × ULN (or ≤ 5 × ULN in patients with known hepatic metastases)
• Adequate renal function, defined as:
• Serum creatinine within normal limits OR creatinine clearance ≥ 50 mL/min (Cockcroft-Gault)
• For patients with BMI < 18.5 or > 30, eGFR ≥ 50 mL/min (MDRD) is acceptable
• Adequate cardiac function, defined as LVEF ≥ 50% by MUGA scan or echocardiography.
• Women of childbearing potential and men with partners of childbearing potential must agree to use effective contraception.

Критерии исключения

• Patients meeting any of the following criteria will be excluded from the study:
• Histology at initial diagnosis of small-cell lung cancer (SCLC), large-cell carcinoma, or mixed tumor with predominant SCLC, large-cell, or neuroendocrine components.
• Prior treatment with a standard SCLC chemotherapy regimen (e.g., carboplatin/etoposide or cisplatin/etoposide) after SCLC transformation.
• Symptomatic or unstable brain metastases. Patients with a history of unstable brain metastases must have undergone definitive surgery or radiotherapy, remain clinically stable, and be off corticosteroids for cerebral edema for at least 14 days before enrollment.
• Any concurrent malignancy other than basal cell carcinoma of the skin or carcinoma in situ of the cervix. (Patients with a prior malignancy must be disease-free for ≥ 5 years to be eligible.)
• Pregnancy (confirmed by serum ß-hCG) or breastfeeding. Note: Women who have been postmenopausal for ≥ 12 months, or who have undergone hysterectomy, bilateral oophorectomy, or bilateral tubal ligation, are exempt from contraception requirements. Male participants must use effective contraception from the first dose of study drug until 180 days after the last dose.
• Active hepatitis B (HBV DNA > 1,000 IU/mL) or hepatitis C infection (anti-HCV positive and/or HCV RNA > 15 IU/L), or known HIV infection.
• Known hypersensitivity to lietinib, carboplatin, or etoposide.
• Psychiatric or cognitive disorders that would preclude informed consent or compliance with study requirements.
• Women planning pregnancy during the screening period or who, along with their partners, are not using effective contraception.
• Any other medical or psychosocial condition judged by the investigator to compromise patient safety or study integrity (e.g., poor compliance or comorbidities affecting efficacy assessment).

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Нет

Дизайн исследования

Распределение

Не применимо

Модель

Одна группа

Маскирование

Открытое

Основная цель

Лечение

Центры проведения

Китай · 1 центр

• Yongchang Zhang — Чанша

Идентификаторы

NCT: NCT07001995 · CALLISTO

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

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