The Potential Role of Compounds Derived From Ultra-processed Foods in the Pathogenesis of Atopic Dermatitis in Pediatric Age

Официальное название

The Potential Role of Compounds Derived From Ultra-processed Foods in the Pathogenesis: the UPAD Project

Обзор

Atopic dermatitis (AD) is a common chronic inflammatory skin condition, primarily affecting children in urban and high-income areas. Its prevalence has increased significantly over the past 30 years, with up to 20% of children affected, often within their first year of life. AD is characterized by erythematous, scaly, pruritic lesions, xerosis, and frequent atopy, with distinct clinical features in children compared to adults. The pathophysiology of AD involves skin barrier dysfunction, immune response alterations, and environmental triggers. Genetic factors, particularly mutations in the filaggrin gene, play a significant role in severe AD, leading to increased water loss and skin dehydration. Immunologically, a Th2-predominant response drives inflammation, and environmental exposures, such as air pollutants and irritants, exacerbate the condition. Recent studies suggest that dietary habits, particularly a high intake of ultra-processed foods (UPFs), may contribute to AD by activating inflammatory pathways. UPFs, rich in advanced glycation end products (AGEs), induce oxidative stress and inflammation, potentially worsening skin damage. This study aims to explore the potential role of UPF-derived compounds, especially AGEs, in the pathogenesis of pediatric AD.

Вмешательства

• Другое Evaluation of dietary consumption of UPFs
  Evaluation of dietary consumption of ultraprocessed foods

Первичные конечные точки

• Comparative evaluation of dietary consumption of ultraprocessed foods (UPFs) [Срок оценки: First year]

Вторичные конечные точки (5)

• Comparative evaluation of dietary consumption of dietary advanced glycation end products (AGEs) [Срок оценки: First year]
• Assessment of skin AGEs accumulation level [Срок оценки: First year]
• Assessment of the effects of AGEs on the expression of tight junction proteins in human keratinocytes [Срок оценки: Second year]
• Effects of AGEs intake on SCORAD/EASI scores [Срок оценки: First year]
• Evaluation of transepidermal water loss (TEWL) [Срок оценки: First year]

Критерии участия

Критерии включения

• Caucasian subjects, both sexes, age: ≥6 months and ≤10 years, with a confirmed diagnosis of atopic dermatitis, and healthy controls matched for age and sex without atopic dermatitis;
• Written informed consent obtained from the participants and/or their parents/legal guardians.

Критерии исключения

• Non-Caucasian ethnicity; age < 6 or > 10 years
• Presence of other chronic conditions: hypereosinophilic syndrome, fungal or viral infections, connective tissue disorders, autoimmune diseases, vasculitis, bullous dermatoses (e.g., pemphigus), drug hypersensitivity reactions, graft-versus-host disease, monogenic disorders (e.g., Marfan syndrome type 2, Hyper-IgE syndrome)
• Presence of scars, nevi, or unusual skin lesions on both forearms
• Absence of written informed consent

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Нет

Дизайн исследования

Модель наблюдения

Случай-контроль

Центры проведения

Италия · 1 центр

• Department of Traslational Medical Science - University of Naples Federico II — Naples

Идентификаторы

NCT: NCT06996327 · 163/2024

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

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