Evaluation of Aqueous Humor DEL-1 and IL-17 Levels in Diabetic Cataract Patients

Обзор

By comparing DEL-1 and IL-17 levels in the aqueous humor of diabetic cataract patients with the aqueous humor of non-diabetic patients, we aim to understand the biochemical effects of diabetes-related inflammatory processes in the eye.

Подробное описание

Developmental Endothelial Locus-1 (DEL-1) is a molecule related to endothelial cells and is a protein involved in intercellular interactions. It is generally associated with the development and function of endothelial cells lining the inner surface of the vessel. It plays an important role in the regulation of inflammation, the development of vessels and the organization of endothelial cells. It has also been shown to be associated with some types of cancer. It may also be effective in tissue regeneration and healing of injuries.

IL-17 (Interleukin-17) is a group of cytokines that play an important role in the immune system. There are several subtypes of IL-17, the best known and most researched being IL-17A. It regulates the body's immune response to certain infections. It is an important cytokine that initiates and supports the inflammation process. IL-17 plays an important role in the pathogenesis of various autoimmune and inflammatory diseases.

DEL-1 and IL-17 are two different molecules that act on inflammation and immune responses. DEL-1 helps regulate inflammation by protecting vascular health, while IL-17 can accelerate the course of diseases by increasing inflammation.

Diabetes is a systemic disease associated with oxidative stress and chronic inflammation. Retinopathy, cataract and glaucoma diseases develop due to diabetes. DEL-1 is a protein involved in the maintenance of vascular homeostasis and regulation of inflammation. Since diabetic patients have chronic inflammation and microvascular dysfunction, changes in DEL-1 levels may provide important clues to the pathophysiology

Вмешательства

• Диагностический тест Del 1
  During cataract surgery, approximately 0.1-0.2 mL of aqueous humor will be sampled with a sterile 27 gauge syringe before viscoelastic is introduced into the anterior chamber. DEL 1 will be analyzed by ELISA
• Диагностический тест IL 17
  During cataract surgery, approximately 0.1-0.2 mL of aqueous humor will be sampled with a sterile 27 gauge syringe before viscoelastic is introduced into the anterior chamber. IL 17 levels will be analyzed by ELISA

Первичные конечные точки

• DEL-1 and IL-17 levels [Срок оценки: Perioperative]

Вторичные конечные точки (3)

• Correlation between DEL-1 and IL-17 [Срок оценки: Perioperative]
• Association of biomarker levels with HbA1c [Срок оценки: Perioperative]
• Impact of demographic factors [Срок оценки: Baseline]

Критерии участия

Критерии включения

• Cataract diagnosed and surgery planned
• Patients without any other ocular pathology other than cataract.
• Type 2 DM for at least 5 years in the diabetic group

Критерии исключения

• Patients with previous intraocular surgery
• Those with inflammatory eye diseases (e.g. uveitis)
• Those with autoimmune diseases or systemic inflammatory diseases
• Those receiving local or systemic steroid therapy
• Those with severe systemic disease (e.g. advanced renal failure, malignancy)

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Да

Дизайн исследования

Распределение

Нерандомизированное

Модель

Перекрёстный дизайн

Маскирование

Простое слепое

Основная цель

Скрининг

Центры проведения

Turkey (Türkiye) · 1 центр

• Uşak Training and Research Hospital — Uşak

Публикации

• Dogruya S, Sagkan RI. Levels of DEL-1 and IL-17 in the aqueous humor of cataract patients with diabetes without diabetic retinopathy. Int Ophthalmol. 2026 Jun 25;46(1):270. doi: 10.1007/s10792-026-04142-3. PMID 42347979

Идентификаторы

NCT: NCT06995131 · DEL 1- IL 17

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

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