Clinimetric Properties of Muscle Mass and Stiffness Measurements of the Quadriceps in Patients With COPD
Ориентир для пациента и семьи
Простыми словами
Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.
- Что изучают
- В протоколе указаны: Perimetry and ShearWave measurement of the quadriceps muscle before and after a pulmonary rehabilitation (PR) programme.
- Кому может быть актуально
- Состояния в реестре: COPD, Quadriceps Muscle Atrophy. Базовые параметры: от 18 лет · Все.
- Что важно проверить
- Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
- Где проводится
- Франция
- Следующий шаг
- Сохраните исследование, покажите его лечащему врачу и уточните актуальный статус у исследовательского центра. Расходы, документы и поездка →
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Официальное название
Clinimetric Properties Assessment of Quadriceps Muscle Mass and Stiffness Using Perimetry and ShearWave Elastography in Patients With COPD : a Prospective Observational Study
Обзор
A large amount of patients with COPD suffer from muscle dysfunction characterized by losses of muscle mass and strength. Studies have shown an association between a loss of quadriceps muscle mass and premature death. This study aims to investigate the clinimetric properties of a simple quadriceps perimetry and ShearWave elastography to improve the monitoring of skeletal muscle function in patients with COPD.
Подробное описание
Muscle dysfunction in COPD is characterized by reduced skeletal muscle mass and strength, particularly in the lower limbs. These systemic consequences of COPD play a key role in the course of these patients, through their impact on functional status, quality of life and increased mortality. Early detection and monitoring of muscular status in these patients could help improve management and limit the consequences of the disease.
Numerous studies show that variation in quadriceps mass has a significant relationship with premature mortality in this disease. The use of an indirect but simple and affordable measure: perimetric tape-measurement of thigh circumference, could help monitor quadriceps muscle mass in these patients on a regular and cost-effective basis. However, the clinimetric properties (validity, reliability, response to treatment) of this measurement need to be assessed to clarify its relevance.
On the other hand, ShearWave ® elastography (SWE) is a new method of measuring quadriceps stiffness. This measurement could provide additional information on muscle quality compared with conventional measures of strength or muscle trophicity. The potential added value of SWE ® for COPD patients has not yet been investigated. This tool would provide more precise indications of the state of the quadriceps, with the aim of improving the management of this pathology.
Вмешательства
- Диагностический тест Perimetry and ShearWave measurement of the quadriceps muscle before and after a pulmonary rehabilitation (PR) programme
Patients will undergo a pulmonary rehabilitation (PR) programme. On day 1, perimetry and ShearWave measurements of the quadriceps muscle will be provided. Supplementary assessments of quadriceps thickness, quadriceps strength with a handheld dynamometry, lean body mass (bioelectrical impedance), constant work-rate endurance test and HAD questionnaire will also be provided on day 1. The same measurements and questionnaire will be provided on the last day of the patient in the PR programme.
Первичные конечные точки
- Perimetry of the quadriceps [Срок оценки: At day 1 and after 5 weeks (at the end of the 5 weeks pulmonary rehabilitation program)]
- Quadriceps stiffness [Срок оценки: At day 1 and after 5 weeks (at the end of the 5 weeks pulmonary rehabilitation program)]
Вторичные конечные точки (5)
- Lean body mass [Срок оценки: At day 1 and after 5 weeks (at the end of the 5 weeks pulmonary rehabilitation program)]
- Functional exercise capacity [Срок оценки: At day 1 and after 5 weeks (at the end of the 5 weeks pulmonary rehabilitation program)]
- Health-Related Quality of Life [Срок оценки: At day 1 and after 5 weeks (at the end of the 5 weeks pulmonary rehabilitation program)]
- Quadriceps thickness [Срок оценки: At day 1 and after 5 weeks (at the end of the 5 weeks pulmonary rehabilitation program)]
- Quadriceps strength [Срок оценки: At day 1 and after 5 weeks (at the end of the 5 weeks pulmonary rehabilitation program)]
Критерии участия
Критерии включения
- COPD patients
- Adults (>18 years old)
- Patients starting a pulmonary rehabilitation (PR) programme
Критерии исключения
- Patients included in other research protocol
- Minors or under guardianship
- Pregnancy
- Patients with lower limb amputation or history of neuromuscular disease
- Cardiovascular contradications for PR
Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.
Здоровые добровольцы: Нет
Дизайн исследования
- Модель наблюдения
- Когортное
Центры проведения
Франция · 1 центр
- Groupe Hospitalier du Havre — Le Havre
Идентификаторы
NCT: NCT06994689 · 2022-A00297-36