Memory Training in Insomnia With Cognitive Impairment

Chronic insomnia (CI) is a prevalent sleep disorder that not only causes night-time sleep difficulties but also impairs daytime functioning and cognitive abilities, including deficits in attention, memory, and executive function. Persistent insomnia may diminish the brain's information processing capacity, affecting memory, attention, and decision-making. CRT, a structured cognitive training intervention, has been shown in psychiatric populations to enhance memory, attention, and executive function by promoting neuroplasticity, neurotransmitter modulation, and optimizing brain activity patterns.

Applying CRT to CI patients may similarly support cognitive recovery and indirectly improve sleep quality. However, empirical evidence remains limited.

This randomized controlled trial will enroll 70 patients with CI and cognitive decline. Participants will be randomly assigned to either a CRT plus Sleep Hygiene Education (SHE) group or an SHE-only group (n=35 each). The CRT intervention will last 6 weeks, with daily 50-minute sessions. Evaluations will occur at baseline, post-intervention, and at 3, 6, and 12 months follow-up. This study aims to provide evidence for CRT as a treatment for CI with cognitive impairment and inform future clinical practices.

• The change of PSQI total scores from baseline to 3 months, 6 months, and 12 months. [Срок оценки: Baseline, 3 months, 6 months, 12 months]
• The change of Insomnia severity index (ISI) total scores from baseline to 6 weeks, 3 months, 6 months, and 12 months. [Срок оценки: Baseline, 6 weeks, 3 months, 6 months, and 12 months]
• The change of sleep efficiency from baseline to 6 weeks, 3 months, 6 months, and 12 months. [Срок оценки: Baseline, 6 weeks, 3 months, 6 months, and 12 months]
• The change of Dysfunctional Beliefs and Attitudes about Sleep Scale (DBAS) total scores from baseline to 6 weeks, 3 months, 6 months, and 12 months. [Срок оценки: Baseline, 6 weeks, 3 months, 6 months, and 12 months]
• The change of Snaith-Hamilton Pleasure Scale (SHAPS) total scores from baseline to 6 weeks, 3 months, 6 months, and 12 months. [Срок оценки: Baseline, 6 weeks, 3 months, 6 months, and 12 months]
• The change of Short Form 36 (SF-36) total scores from baseline to 6 weeks, 3 months, 6 months, 12 months. [Срок оценки: Baseline, 6 weeks, 3 months, 6 months, and 12 months.]
• The change of Patient Health Questionnaire-4 (PHQ-4) total scores from baseline to 6 weeks, 3 months, 6 months, and 12 months. [Срок оценки: Baseline, 6 weeks, 3 months, 6 months, and 12 months]
• The change of Beck Depression Inventory (BDI) total scores from baseline to 6 weeks, 3 months, 6 months, and 12 months. [Срок оценки: Baseline, 6 weeks, 3 months, 6 months, and 12 months]
• The change of Beck Anxiety Inventory (BAI) total scores from baseline to 6 weeks, 3 months, 6 months, and 12 months. [Срок оценки: Baseline, 6 weeks, 3 months, 6 months, and 12 months]
• The change of Patient Health Questionnaire-15 (PHQ-15) total scores from baseline to 6 weeks, 3 months, 6 months, and 12 months. [Срок оценки: Baseline, 6 weeks, 3 months, 6 months, and 12 months]
• The change of 5-item Perceived Deficits Questionnaire-Depression (PDQ-D-5) total scores from baseline to 6 weeks, 3 months, 6 months, and 12 months. [Срок оценки: Baseline, 6 weeks, 3 months, 6 months, and 12 months]
• The change of Life Events Scale (LES) total scores from baseline to 6 weeks, 3 months, 6 months, and 12 months. [Срок оценки: Baseline, 6 weeks, 3 months, 6 months, and 12 months]