Analysis of Muscle Oxygen Saturation and Functional Variables During Physical Capacity Assessments in Patients With COPD

This experimental pre-post study investigates the effects of a combined respiratory physiotherapy and physical training program on muscle oxygen saturation and functional capacity in patients diagnosed with Chronic Obstructive Pulmonary Disease (COPD). COPD is a highly prevalent condition with a progressive impact on functional capacity, muscle performance, and quality of life. It is associated with systemic repercussions, including skeletal muscle dysfunction and oxygen transport limitations, which impair tolerance to physical activity.

The study will evaluate the acute and cumulative effects of a structured, supervised intervention including respiratory physiotherapy techniques, cardiovascular training, and progressive resistance training. Measurements will be taken before and after the intervention period to assess changes in muscle oxygen saturation-measured using near-infrared spectroscopy (NIRS) devices (Moxy Monitor)-in key muscle groups (intercostal, quadriceps, and triceps surae).

Functional capacity will be assessed using the 6-Minute Walk Test (6MWT) and the 30-Second Chair Stand Test (30CST). Additional variables including inspiratory and expiratory pressures, pulmonary function (FEV1/FEV6), heart rate variability, dyspnea, lower limb fatigue, and quality of life (COPD Assessment Test) will also be recorded.

The intervention consists of 20 hospital-based sessions over four weeks (five sessions per week). The protocol is designed to reflect real clinical settings and aims to provide evidence for the feasibility, safety, and functional relevance of combining respiratory and musculoskeletal rehabilitation strategies in COPD patients.

• Distance covered in 6-Minute Walk Test (6MWT) [Срок оценки: From baseline to after the 4-week intervention]
• Number of repetitions in the 30-Second Chair Stand Test [Срок оценки: From baseline to after the 4-week intervention]
• Perceived dyspnea and lower limb fatigue (Borg Scale) [Срок оценки: From baseline to after the 4-week intervention]
• Maximal inspiratory and expiratory pressures (Pimax and Pemax) [Срок оценки: From baseline to after the 4-week intervention]
• FEV1/FEV6 ratio (portable COPD Vitalograph) [Срок оценки: From baseline to after the 4-week intervention]
• Heart rate variability and max/min heart rate (Polar system + Kubios HRV) [Срок оценки: From baseline to after the 4-week intervention]
• Quality of life (COPD Assessment Test - CAT) [Срок оценки: From baseline to after the 4-week intervention]