The Effect of Inspiratory Muscle Training With Substance Use Disorder

Обзор

The aim was to investigate the effectiveness of inspiratory muscle training on dyspnoea, pulmonary function, respiratory muscle strength, cough capacity, functional exercise capacity, substance craving, depression, anxiety and quality of life in individuals with substance use disorder.

Подробное описание

In recent years, substance use has increased among young people in our country, and studies investigating the negative effects of substances on pulmonary health have also increased. It has been emphasized in the literature that the most appropriate features should be determined for the exercise program in the treatment of individuals with SUD. Although studies in the literature have reported that substance use affects respiratory functions and creates a restrictive or obstructive pattern, no study investigating the effects of inspiratory muscle training has been found in the literature. To our knowledge, this study is the first to examine the effects of inspiratory muscle training on respiratory function in individuals with SUD. In our study, it was assumed that inspiratory muscle training could be a simple and inexpensive technique to improve dyspnea, respiratory functions, respiratory muscle strength, cough capacity, and exercise capacity in individuals with SUD, reduce substance cravings, increase quality of life, and reduce depression and anxiety, thus making it suitable for routine clinical use. The aim was to examine the effectiveness of inspiratory muscle training on dyspnea, respiratory functions, respiratory muscle strength, functional exercise capacity, substance craving, anxiety, depression, and quality of life in individuals with substance use disorders.

Вмешательства

• Другое Inspiratory muscle training programme
  In addition to their standard treatment, individuals in the inspiratory muscle training group will participate in inspiratory muscle training for a total of 30 minutes with a threshold loading device (POWERbreathe®) for 15 minutes twice a day, 5 days a week for 4 weeks under the supervision of a physiotherapist.
• Другое control group
  Individuals in the control group will continue their standard treatment. No changes will be made in the medical treatments (type, dosage and frequency) of the individuals in both groups (the inspiratory muscle training group and the control group) during the study.

Первичные конечные точки

• Dyspnea [Срок оценки: 4 weeks]
• Respiratory Functions (FEV1) [Срок оценки: 4 weeks]
• Respiratory Functions (FVC) [Срок оценки: 4 weeks]
• Respiratory Functions (FEV1/FVC) [Срок оценки: 4 weeks]
• Respiratory Functions (FEF 25-75%) [Срок оценки: 4 weeks]
• Respiratory Functions (PEF) [Срок оценки: 4 weeks]
• Respiratory Muscle Strength [Срок оценки: 4 weeks]
• Cough Capacity [Срок оценки: 4 weeks]
• Functional exercise capacity [Срок оценки: 4 weeks]

Вторичные конечные точки (3)

• Penn Substance Craving Scale [Срок оценки: 4 weeks]
• Health-related quality of life [Срок оценки: 4 weeks]
• Anxiety and Depression [Срок оценки: 4 weeks]

Критерии участия

Критерии включения

• Being older than 18 years

• Meeting the current Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-5) criteria for Substance Use Disorder
• Receiving inpatient treatment
• Substance use for more than one year
• Being able to follow simple instructions
• Not having any visual and auditory pathology
• Being able to cooperate with the devices used.

Критерии исключения

• Failure to comply with the treatment and assessment program
• Participation in a structured physiotherapy/exercise program in the last 6 months
• Presence of current psychotic symptoms
• Presence of any physical disability or medical problem
• Presence of respiratory system problems such as asthma and tuberculosis and infectious health problems (e.g. HIV, hepatitis B).

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Нет

Дизайн исследования

Распределение

Рандомизированное

Модель

Параллельные группы

Маскирование

Открытое

Основная цель

Лечение

Центры проведения

Turkey (Türkiye) · 1 центр

• Üsküdar University — Istanbul

Публикации

• Sivasothy P, Brown L, Smith IE, Shneerson JM. Effect of manually assisted cough and mechanical insufflation on cough flow of normal subjects, patients with chronic obstructive pulmonary disease (COPD), and patients with respiratory muscle weakness. Thorax. 2001 Jun;56(6):438-44. doi: 10.1136/thorax.56.6.438. PMID 11359958
• Black LF, Hyatt RE. Maximal respiratory pressures: normal values and relationship to age and sex. Am Rev Respir Dis. 1969 May;99(5):696-702. doi: 10.1164/arrd.1969.99.5.696. No abstract available. PMID 5772056
• Laszlo G. Standardisation of lung function testing: helpful guidance from the ATS/ERS Task Force. Thorax. 2006 Sep;61(9):744-6. doi: 10.1136/thx.2006.061648. PMID 16936234

Идентификаторы

NCT: NCT06961838 · ÜsküdarÜ2025

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

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