Идёт набор NCT06960798

Characterizing the Genomic Landscape of Prostate Cancer in Native American Populations (NAT-Geno)

— Наблюдательное Prostate Cancer

Ориентир для пациента и семьи

Простыми словами

Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.

Что изучают: В протоколе указаны: Bio-specimen Collection, Blood Draw.
Кому может быть актуально: Состояния в реестре: Prostate Cancer. Базовые параметры: 18 лет — 100 лет · Мужчины.
Что важно проверить: Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
Где проводится: США
Следующий шаг: Сохраните исследование, покажите его лечащему врачу и уточните актуальный статус у исследовательского центра. Расходы, документы и поездка →

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Официальное название

Characterizing the Genomic Landscape of Prostate Cancer in Native American Populations (Nat-Geno)

Обзор

The purpose of this study is to analyze tumor tissue samples from patients of Native American identity with prostate cancer. By examining these samples, researchers hope to understand how different genes in your tumor can influence treatment decisions, how your cancer progresses and the outcome of your cancer.

Подробное описание

This study aims to establish a comprehensive database of Native American (NA) patients diagnosed with prostate cancer (PC), focusing on an in-depth characterization of the genomic landscape. Archived tumor tissue collected at screening and peripheral blood samples obtained within the first year of enrollment will serve as the basis for comprehensive molecular analyses. Whole exome sequencing (WES) and whole transcriptome sequencing (RNA-seq) will be performed to characterize and delineate the genomic and transcriptomic landscape of the study cohort. The study will initially enroll participants at the Stephenson Cancer Center, with planned expansion to additional sites across Oklahoma and, subsequently, to other institutions across the United States. Oversight will be maintained by the Tribal Institutional Review Board and an independent Community Advisory Board to ensure cultural appropriateness, transparency, and sustained community engagement throughout the research process. The overarching objective is to generate insights that will inform the development of personalized treatment strategies in the future.

Вмешательства

Другое Bio-specimen Collection
Tissue samples will be taken from existing archived collections and sent for further analysis.
Другое Blood Draw
Blood samples will be collected within the first year of enrollment.

Первичные конечные точки

Difference in the genomic profiles of Prostate Cancer [Срок оценки: 1-3 years]

Вторичные конечные точки (1)

Comparison of Genomic Profiles [Срок оценки: 1-3 years]

Критерии участия

Критерии включения

Written informed consent signed and dated by the patient prior to the performance of any study-specific procedures, sampling, or analyses.
At least 18 years-of-age at the time of signature of the informed consent form (ICF).
Patients who self-identify as Native American.
Patients with a pathologically proven diagnosis of PC (any stage).
Availability of most recent archived tumor samples.