Mechanisms And Prognosis of Stroke-Heart Syndrome

Обзор

The incidence of stroke-heart syndrome following acute stroke, which encompasses both acute ischemic stroke and acute intracerebral hemorrhage, is notably high and is strongly associated with increased mortality and poor outcomes in stroke patients. However, the underlying mechanisms remain unclear, and there are currently no effective prevention or treatment strategies. This study aims to elucidate the neuro-humoral mechanisms of stroke-heart syndrome through multimodal imaging and multi-omics blood analysis. Additionally, it seeks to observe the progression of stroke-heart syndrome and its impact on functional outcomes, cognitive abilities, and emotional issues post-stroke. The research is expected to uncover novel blood biomarkers and brain network mechanisms associated with stroke-heart syndrome, providing potential targets and theoretical foundations for pharmacological treatments or physical interventions. Furthermore, it aims to establish a risk early-warning system for major cardiovascular complications post-stroke, enabling early identification, early intervention, and integrated brain-heart management to improve clinical outcomes for stroke patients.

Первичные конечные точки

• blood high-sensitivity cardiac troponin level [Срок оценки: within 48 hours and at 72 hours after stroke onset]
• left ventricular ejection fraction [Срок оценки: within 1 week after stroke onset]
• blood N-terminal pro-brain natriuretic peptide (NT-proBNP) level [Срок оценки: within 1 week after stroke onset]
• functional outcome [Срок оценки: 3 months and 1 year after stroke onset.]
• death [Срок оценки: 1 month, 3 months and 1 year after stroke onset]

Вторичные конечные точки (3)

• post-stroke cognitive impairment [Срок оценки: 3 months and 1 year after stroke onset.]
• post-stroke depression [Срок оценки: 3 months and 1 year after stroke onset.]
• post-stroke anxiety [Срок оценки: 3 months and 1 year after stroke onset.]

Критерии участия

Критерии включения

• Patients admitted within 48 hours of onset, confirmed by CT/MRI as having a stroke (including acute ischemic stroke and hemorrhagic stroke).
• Moderate-to-severe stroke with NIHSS ≥ 5.

Критерии исключения

• Previous focal brain injury (such as stroke, brain surgery, traumatic brain injury, etc.).
• Brain dysfunction caused by other major neurological disorders than stroke (such as brain tumors, epilepsy, Parkinson's disease, etc.).
• Transient ischemic attack (TIA) and subarachnoid hemorrhage (SAH).
• History of cardiac diseases (such as coronary heart disease, heart failure, severe arrhythmias, congenital heart disease, cardiac surgery, valvular heart disease, or undiagnosed significant cardiac symptoms).
• Concomitant systemic diseases such as renal failure (eGFR < 30), autoimmune disorders, severe infections, etc.
• History of dementia, depression, or other psychiatric disorders.
• Poor compliance and inability to cooperate with follow-up.

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Нет

Дизайн исследования

Модель наблюдения

Когортное

Центры проведения

Китай · 1 центр

• Department of Neurology, Tongji hospital, Tongji medical college, Huazhong University of S — Ухань

Идентификаторы

NCT: NCT06954103 · TJ-IRB202502010

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

Открыть это исследование на ClinicalTrials.gov ↗