Improving Engagement in HIV and Cancer Care in Zimbabwe

Официальное название

Development and Evaluation of a Multi-Component Intervention to Support HIV Care Engagement Among Patients Receiving Cancer Treatment in Zimbabwe

Обзор

In Zimbabwe, people who have cancer and HIV may have a difficult time staying engaged in their HIV care while they are being treated for cancer. This is because HIV and cancer care are usually provided at different health facilities, which can result in barriers to accessing clinical care for both HIV and cancer at the same time. It is important to remain engaged in HIV care, and continue taking medication to treat HIV throughout cancer treatment. The goal of this project is to identify barriers that make it difficult to stay engaged in HIV care and continue HIV treatment during cancer treatment and develop strategies to address them. The investigators will accomplish this by first observing a group of 150 people with cancer and HIV who are receiving cancer treatment at Parirenyatwa Hospital, in Harare, Zimbabwe. The investigators will measure barriers to accessing HIV care, and disruptions to HIV care engagement during cancer treatment. Next, the investigators will work with experts and key stakeholders to develop strategies that can be put in place at Parirenyatwa Hospital to better support engagement in HIV care during cancer treatment. The investigators will work with the cancer ward at the hospital to implement these strategies. Finally, the investigators will observe a second group of 150 people with cancer and HIV, who begin their cancer treatment at Parirenyatwa Hospital after the strategies have been put in place. The investigators will measure acceptability of these strategies to both patients and hospital staff. The investigators will also measure barriers to accessing HIV care and disruptions to HIV care engagement in the second group. The investigators will compare barriers to HIV care and HIV care engagement in the second group to the first group, to determine whether the strategies make it easier for people with cancer and HIV to remain engaged in HIV care during cancer treatment.

Вмешательства

• Другое Strategies to improve HIV care engagement
  Based on the barriers to HIV care experienced by the pre-intervention cohort, we will design a system intervention to be implemented at the Radiotherapy Centre at Parirenyatwa Hospital. This intervention will include 2-3 components, each intended to improve engagement in HIV care or address specific barriers to HIV care. It may include strategies like improving documentation of HIV-related information in oncology patient records, improving processes for referrals and access to HIV-related prescr

Первичные конечные точки

• Acceptability of strategies to improve engagement in HIV care during cancer treatment [Срок оценки: Acceptability assessed at Months 1, 3, and 6 after enrollment in pilot cohort]

Вторичные конечные точки (3)

• Missed ART prescription refills [Срок оценки: From enrollment through 6 months of follow-up or completion of cancer treatment]
• ART adherence [Срок оценки: From enrollment through 6 months of follow-up or completion of cancer treatment]
• Missed HIV clinical visits [Срок оценки: From study enrollment through 6 months of follow-up or completion of cancer treatment]

Критерии участия

Критерии включения

• Age 18 or older
• Registered patient at Parirenyatwa Hospital Radiotherapy Centre, receiving cancer treatment for a new diagnosis
• HIV-positive

Критерии исключения

• Benign diagnosis or cancer recurrence

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Нет

Дизайн исследования

Распределение

Нерандомизированное

Модель

Последовательный дизайн

Маскирование

Открытое

Основная цель

Организация здравоохранения

Центры проведения

Zimbabwe · 1 центр

• Parirenyatwa Hospital — Harare

Идентификаторы

NCT: NCT06934369 · RG1123169 · K01MH132505 · NCI-2023-02951 · 11131

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

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