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Набор скоро начнётся NCT06931756

Effects of Uremia on Brachial Plexus Electrophysiology and Brachial Plexus Block

Без фазы С лечением Electrical Stimulation of Nerves Produces Muscle Reflexes

Ориентир для пациента и семьи

Простыми словами

Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.

Что изучают
В протоколе указаны: Neural Stimulator.
Кому может быть актуально
Состояния в реестре: Electrical Stimulation of Nerves Produces Muscle Reflexes. Базовые параметры: от 18 лет · Все.
Что важно проверить
Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
Где проводится
Список центров уточняется — проверьте первичный протокол.
Следующий шаг
Сохраните исследование, покажите его лечащему врачу и уточните актуальный статус у исследовательского центра. Расходы, документы и поездка →

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Официальное название

Effects of Uremia on Brachial Plexus Electrophysiology and Brachial Plexus Block: One Prospective Parallel Cohort Study

Обзор

As a late stage of renal failure, uremia not only leads to severe impairment of renal function in patients, but also often leads to a variety of complications, among which multiple peripheral neuropathy is particularly common. This lesion is mainly caused by the combination of multiple mechanisms, such as the accumulation of uremic toxins, electrolyte disorder, nutrient deficiency and factors related to hemodialysis. Therefore, it is important clinical significance to deeply explore the effects of uremia on electrophysiological properties and nerve block of brachial plexus. At present, there are relatively few studies on the effects of uremia on the brachial plexus, especially the prospective parallel cohort studies on its electrophysiological properties and nerve block. As a new anesthetic technique, ultrasound-guided axillary brachial plexus block has the advantages of precise positioning, scientific administration, reducing complications and improved safety, but the application effect and safety in uremic patients still need to be further verified.

Вмешательства

  • Устройство Neural Stimulator
    Adjust the neural stimulator, with a stimulation duration of 0.1 ms, a stimulation frequency of 1Hz, and a stimulation current of 1.0mA. Under ultrasound guidance, the needle tip is used to touch the radial nerve, ulnar nerve, median nerve, and musculocutaneous nerve respectively, until a clear motor response is observed in the corresponding muscles. Thereafter, the minimum stimulation threshold current is verified by reducing the current until the distal motor response disappears. If no motor r

Первичные конечные точки

  • The difference in the minimum excitatory threshold current for motor electrical stimulation of the radial, ulnar, median, and musculocutaneous nerves between patients with uremia and those without uremia. [Срок оценки: one year]
Вторичные конечные точки (4)
  • The onset time of forearm sensory block in two groups of patients [Срок оценки: one year]
  • Onset time of forearm motor block in two groups of patients [Срок оценки: one year]
  • The recovery time of forearm sensation in two groups of patients [Срок оценки: one year]
  • Recovery time for forearm movement in two groups of patients [Срок оценки: one year]

Критерии участия

Критерии включения

  • Uremia group \[group U\]
  • Patients aged 18 years and older
  • ASA classification I-IV
  • BMI 18.5-29.9
  • Patients with uremia planning to undergo forearm or hand surgery
  • Diagnostic criteria: Patients must meet the internationally recognized diagnostic criteria for uremia and require hemodialysis
  • Informed consent: Patients or their legal representatives must sign an informed consent form, agreeing to participate in this study and undergo related examinations and treatments
  • Non-uremia group \[Group N\]
  • Patients aged 18 years and older
  • ASA classification I-IV
  • BMI 18.5-29.9
  • Patients planning to undergo forearm or hand surgery
  • In addition to possibly having diabetes, patients should not have any other diseases that could cause peripheral neuropathy
  • The patient or their legal representative must sign an informed consent form, agreeing to participate in this study and receive the relevant examinations and treatments

Критерии исключения

  • Individuals allergic to study medications (such as ropivacaine)
  • Those with contraindications to local anesthesia or nerve blockades, such as coagulation disorders, infections, etc.
  • Those with severe cardiovascular or respiratory diseases
  • Those unable to comply with study requirements, such as cognitive impairment, mental disorders, etc.
  • Pregnant women

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Нет

Дизайн исследования

Распределение
Нерандомизированное
Модель
Параллельные группы
Маскирование
Открытое
Основная цель
Диагностика

Центры проведения

Список центров уточняется — проверьте первичный протокол.

Идентификаторы

NCT: NCT06931756 · KY20250123-09

Первоисточники (государственные реестры)

Открыть это исследование на ClinicalTrials.gov ↗