Suicide Preventive Psychosocial Treatment for Youths

The overall objective of this project is to evaluate the efficacy, durability, and cost-effectiveness of the SAFETY intervention, a scalable suicide prevention intervention that can be offered immediately following a youth suicide attempt, in a single-blind randomized controlled multisite superiority trial.

PRIMARY OBJECTIVE To determine the clinical efficacy of SAFETY for reducing suicide re-attempt in youths with a recent suicide attempt, compared with enhanced treatment as usual within child and adolescent mental health care (E-TAU). The primary endpoint is the follow-up 3 months post-treatment.

SECONDARY OBJECTIVES

1. To determine the clinical efficacy of SAFETY for nonsuicidal self-injury, global functioning, anxiety, depression, and hopelessness in youths with a recent suicide attempt, compared with E-TAU. The primary endpoint is the follow-up 3 months post-treatment. 2. To evaluate the clinical efficacy of SAFETY for a composite outcome of suicide attempts and nonsuicidal self-injury, in order to enable comparison with other studies. 3. To establish the 12-month durability of the treatment effects. 4. To conduct a health-economic evaluation of SAFETY for youth with a recent suicide attempt, compared with E-TAU, from multiple perspectives, both in the short term (primary endpoint) and the long term (12-month follow-up). 5. To test predictors and moderators of treatment effect, including factors related to baseline levels of the outcomes, comorbidity, personality, family functioning, parental factors, school experience, peer support, and traumatic experiences. 6. Test whether emotion regulation, thwarted belongingness and perceived burdensomeness, parental invalidation, and family functioning mediate treatment outcome. 7. Long-term follow-up from post-treatment to 60-month post-treatment including patient-reports and parent-reports, as well as psychiatric disorders, clinical care consumption, pharmacological prescriptions, employment status, and academic performance retrieved from registries.

• Nonsuicidal self-injury - any report from The Deliberate Self Harm Inventory - Youth version (DSHI-Y) [Срок оценки: Pre-treatment, immediately post-treatment, as well as 3-, 12-, 24- and 60-month post-treatment.]
• Work and Social Adjustment Scale, youth version (WSAS-Y) [Срок оценки: Pre-treatment, immediately post-treatment, as well as 3-, 12-, 24- and 60-month post-treatment.]
• Children's global assessment scale (CGAS) [Срок оценки: Pre-treatment, immediately post-treatment, as well as 3-, 12-, 24- and 60-month post-treatment.]
• Revised Children's Anxiety and Depression Scale, 25 item version (RCADS-25) [Срок оценки: Pre-treatment, immediately post-treatment, as well as 3-, 12-, 24- and 60-month post-treatment.]
• Beck's Hopelessness Scale (BHS) [Срок оценки: Pre-treatment, immediately post-treatment, as well as 3-, 12-, 24- and 60-month post-treatment.]
• Child Health Utility 9D (CHU-9D) [Срок оценки: Pre-treatment, immediately post-treatment, as well as 3-, 12-, 24- and 60-month post-treatment.]
• Recovering Quality of Life (ReQoL) [Срок оценки: Pre-treatment, immediately post-treatment, as well as 3-, 12-, 24- and 60-month post-treatment.]
• Trimbos/iMTA questionnaire for Costs associated with Psychiatric illness (TIC-P) [Срок оценки: Pre-treatment, immediately post-treatment, as well as 3-, 12-, 24- and 60-month post-treatment.]