Oxygen Consumption, Hypoperfusion and Organ Injury After Cardio-pulmonary Bypass
Ориентир для пациента и семьи
Простыми словами
Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.
- Что изучают
- В протоколе указаны: Oxygen consumption measurement.
- Кому может быть актуально
- Состояния в реестре: Cardiac Surgery Requiring Cardiopulmonary Bypass. Базовые параметры: от 18 лет · Все.
- Что важно проверить
- Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
- Где проводится
- Швеция
- Следующий шаг
- Сохраните исследование, покажите его лечащему врачу и уточните актуальный статус у исследовательского центра. Расходы, документы и поездка →
Не всё понятно в терминах? Прочитайте наш гид для пациентов →
Официальное название
Oxygen Consumption, Early Postoperative Hypoperfusion and Organ Injury After Cardio-pulmonary Bypass: a Prospective Observational Study
Обзор
The goal of this observational study is to understand how oxygen consumption after heart surgery relates to blood flow problems and organ injury. The study focuses on patients over 18 years old who are having planned heart surgery with a heart-lung machine (cardiopulmonary bypass). The main questions the study aims to answer are: 1. How does oxygen consumption in the early hours after surgery relate to lactate levels (a sign of low oxygen supply to the tissues)? 2. How is oxygen consumption linked to signs of poor blood flow and organ injury (such as heart, kidney, liver, brain, and gut damage)? Researchers will measure oxygen consumption after surgery using a technique called indirect calorimetry. They will also track blood flow and oxygen use during surgery and check for signs of organ injury the day after the procedure. The study will include 65 participants. People with certain health conditions, like severe anemia, high lactate levels before surgery, or needing intensive care or extra oxygen supply before surgery, will not be included. By understanding how oxygen consumption relates to blood flow and organ injury, this research may help to better manage patients after heart surgery and reduce complications.
Вмешательства
- Другое Oxygen consumption measurement
After arrival to the ICU, prior to cessation of iv anaesthetics and extubation, indirect calorimetry will be performed by connecting a metabolic monitor to the ventilator during a minimum of 20 minutes.
Первичные конечные точки
- Difference in oxygen consumption in early postoperative hypoperfusion [Срок оценки: 0-4 hours after surgery]
Вторичные конечные точки (3)
- Evaluation of hypoperfusion parameters as predictors of postoperative oxygen consumption [Срок оценки: 0-24 hours after surgery]
- Evaluation of oxygen delivery and consumption during cardiopulmonary bypass as predictors of postoperative oxygen consumption [Срок оценки: 0-4 hours during and after surgery]
- Evaluation of organ injury biomarkers as predictors of postoperative oxygen consumption [Срок оценки: Preoperative and the day after surgery]
Критерии участия
Критерии включения
- Elective cardiac surgery requiring cardiopulmonary bypass
Критерии исключения
- Combined, redo or annuloplasty procedures
- Surgical procedures involving other vascular cannulation than standard direct, such as bicaval or femoral cannulation
- Preoperative hyperlactatemia (>2mmol/L) or anaemia (Hb <90 g/dL)
- Preoperative need for supplementary oxygen or ICU care
- Consent not obtainable.
Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.
Здоровые добровольцы: Нет
Дизайн исследования
- Модель наблюдения
- Когортное
Центры проведения
Швеция · 1 центр
- Uppsala University Hospital — Uppsala
Идентификаторы
NCT: NCT06930443 · FOU2025-00095 · 284709