Multi-Modality Imaging Standard Cohort Of Cerebrovascular Disease
Ориентир для пациента и семьи
Простыми словами
Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.
- Что изучают
- Это наблюдательное исследование: исследуемое лечение участникам по протоколу не назначают.
- Кому может быть актуально
- Состояния в реестре: Cerebrovascular Disease. Базовые параметры: 18 лет — 80 лет · Все.
- Что важно проверить
- Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
- Где проводится
- Китай
- Следующий шаг
- Сохраните исследование, покажите его лечащему врачу и уточните актуальный статус у исследовательского центра. Расходы, документы и поездка →
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Обзор
The aim of this study is to establish a multi-center and multi-modality imaging standard cohort of cerebrovascular disease, analyze the potential mechanisms affecting the prognosis of cerebrovascular disease based on a variety of imaging methods, and explore potential therapeutic targets.
Подробное описание
Cerebrovascular diseases are major diseases that pose a serious threat to human health and life, and have become the leading cause of death from disease among Chinese residents. Despite the best medical or surgical treatment options, many patients still suffer from functional disabilities, imposing a heavy burden on families and society. Identifying the complex and delicate changes in brain neural activity, blood flow, oxygenation, and metabolism following the occurrence of cerebrovascular diseases can not only explore the potential mechanisms underlying poor functional prognosis, but also provide a scientific basis for targeted treatment strategies. This study is a consecutive, multicenter, prospective registration study that recruits approximately 800 patients with cerebrovascular diseases (both hemorrhagic and ischemic stroke) aged 18-80 years within 7 days of onset. The study collects baseline information and imaging data including head CT, MRI, TCD, fNIRS, and ophthalmic testing. The primary endpoint event was functional outcome 3 months (mRS score). Secondary outcomes were in-hospital complications (including stroke progression, recurrence, and mortality), cognitive disorder, functional outcomes, recurrent stroke, new vascular events, and all-cause death at 3, 6 and 12 months .
Первичные конечные точки
- The incidence of unfavorable functional outcome [Срок оценки: 3 month after enrollment]
Вторичные конечные точки (6)
- The incidence of in-hospital complications [Срок оценки: duration of hospital stay（about 1 week）]
- The incidence of unfavorable functional outcome [Срок оценки: 6 and 12 months after enrollment]
- The incidence of new vascular events [Срок оценки: 3, 6 and 12 months after enrollment]
- The incidence of recurrent stroke [Срок оценки: 3, 6 and 12 months after enrollment]
- The incidence of all-cause death [Срок оценки: 3, 6 and 12 months after enrollment]
- The incidence of Cognitive impairment [Срок оценки: 3, 6 and 12 months after enrollment]
Критерии участия
Критерии включения
- Age between 18 and 80 years old;
- Onset of symptoms within 7 days;
- Clinical diagnosis of cerebrovascular disease (ischemic stroke or hemorrhagic stroke) confirmed by head imaging (CT or MRI);
- Signed informed consent form.
Критерии исключения
- Diagnosed with non-cerebrovascular diseases (such as central nervous system infections, epilepsy, and metabolic encephalopathy);
- Patients with contraindications to multimodal CT or MRI, functional near-infrared imaging, or those who cannot cooperate to complete the relevant examinations;
- Patients with a life expectancy of less than 3 months or those who cannot complete the study follow-up due to other reasons.
Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.
Здоровые добровольцы: Да
Дизайн исследования
- Модель наблюдения
- Когортное
Центры проведения
Китай · 1 центр
- Beijing Tiantan Hospital — Пекин
Идентификаторы
NCT: NCT06925178 · HX-B-2024061