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Идёт набор NCT06906432

Mechanisms of Brain-Heart Injury of Post-Intracranial Hemorrhage

— Наблюдательное Subarachnoid Hemorrhage, Aneurysmal Cerebrocardiac Syndrome Mass Spectrometry Heart Failure

Ориентир для пациента и семьи

Простыми словами

Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.

Что изучают
В протоколе указаны: Multi-disciplinary assessment.
Кому может быть актуально
Состояния в реестре: Subarachnoid Hemorrhage, Aneurysmal, Cerebrocardiac Syndrome, Mass Spectrometry, Heart Failure. Базовые параметры: 18 лет — 80 лет · Все.
Что важно проверить
Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
Где проводится
Китай
Следующий шаг
Сохраните исследование, покажите его лечащему врачу и уточните актуальный статус у исследовательского центра. Расходы, документы и поездка →

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Официальное название

Multimodal Omics and Imaging Study on the Mechanisms of Brain-heart Injury in Patients With Intracranial Hemorrhage

Обзор

Intracranial hemorrhage is a condition characterized by high mortality rates and suboptimal functional outcomes. It precipitates both direct brain injury and subsequent secondary injuries, including delayed cerebral ischemia, brain edema, and hydrocephalus. Complications such as cardiac injury may also arise, categorizing them within the cerebrocardiac syndrome (CCS). The clinical spectrum of CCS encompasses acute myocardial injury, acute coronary syndrome, left ventricular systolic and diastolic dysfunction, cardiac arrhythmias, and sudden cardiac death, all of which are associated with increased mortality and deterioration in patient status. The precise pathophysiological mechanisms underlying both cerebral and cardiac injuries remain enigmatic, and the implications for diagnosis and therapeutic strategies are yet to be fully explored. In this study, we propose to enroll patients with intracranial hemorrhage who will undergo conventional treatment and comprehensive multidisciplinary evaluations. Our observational research is grounded in a multimodal omics and imaging approach, aimed at investigating both local and systemic injuries subsequent to intracranial hemorrhage. This comprehensive strategy is intended to facilitate precise diagnosis, risk stratification, and clinical decision-making, while also shedding light on the pathophysiological mechanisms involved. The primary objectives of this research are to address the following key questions: * \[Question 1\] What are the pathophysiological mechanisms underlying cardiac injury in patients with intracranial hemorrhage? * \[Question 2\] What are the pathophysiological mechanisms responsible for early and delayed brain injuries following intracranial hemorrhage?\"

Вмешательства

  • Диагностический тест Multi-disciplinary assessment
    Multi-disciplinary assessment including blood tests, CSF test, electrocardiograms, ultrasound, imaging, etc

Первичные конечные точки

  • Short-term cardiac events [Срок оценки: At discharge (assessed up to 5 days)]
  • Long-term cardiac events [Срок оценки: 3 months post-discharge]
  • Short-term delayed cerebral ischemia [Срок оценки: At discharge (assessed up to 5 days)]
  • Long-term delayed cerebral ishemia [Срок оценки: 3 months post-discharge]
  • Short-term brain-heart syndrome [Срок оценки: At discharge (assessed up to 5 days)]
  • Long-term brain-heart syndrome [Срок оценки: 3 months post-discharge]
Вторичные конечные точки (2)
  • Short-term modified Rankin Scale scores [Срок оценки: At discharge (assessed up to 5 days)]
  • Long-term modified Rankin Scale scores [Срок оценки: 3 months post-discharge]

Критерии участия

Критерии включения

  • Patients aged 18 years or older at the time of enrollment.
  • Acute intracranial hemorrhage confirmed by neuroimaging (CT, MRI，CTA, MRA, or DSA) within 48 hours of symptom onset.
  • Ability to provide informed consent or have a legally authorized representative willing to consent on their behalf.

Критерии исключения

  • Patients who refuse to participate in the study or cannot provide informed consent.
  • Patients with a history of significant cardiovascular disease, including myocardial infarction, heart failure, or arrhythmias, unless stable and well-controlled.
  • Patients who have undergone cardiac bypass surgery, stent placement, or other cardiovascular interventions within the past 6 months.
  • Patients with active brain tumors, ischemic stroke within 3 months or a history of previous brain injury that could confound the study findings.
  • Patients with active malignant disease, severe inflammatory or infectious disease, or those who have undergone surgery for any reason within the past 3 months.
  • Patients with any condition that, in the opinion of the investigator, would make it unsafe or impractical to participate in the study.

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Да

Дизайн исследования

Модель наблюдения
Когортное

Центры проведения

Китай · 1 центр
  • Beijing Tiantan Hospital Affiliated to Capital Medical University — Пекин

Идентификаторы

NCT: NCT06906432 · BHI2024

Первоисточники (государственные реестры)

Открыть это исследование на ClinicalTrials.gov ↗