Brain Activity During Complex Walking in People With Atypical Parkinsonian Syndromes

Официальное название

Walking and Thinking - Brain Activity During Complex Walking in Atypical Parkinsonian Syndromes

Обзор

Every-day life means being part of a complex environment and performing complex tasks that usually involve a combination of motor and cognitive skills. However, the process of aging or the sequelae of neurological diseases such as atypical Parkinson's disease (APD) compromises motor-cognitive interaction necessary for an independent lifestyle. While motor-cognitive performance has been identified as an important goal for sustained health across different clinical populations, little is known about underlying brain function leading to these difficulties and how to best target these motor-cognitive difficulties in the context of rehabilitation and exercise interventions. The challenge of improving treatments of motor-cognitive difficulties (such as dual-tasking and navigation) is daunting, and an important step is arriving at a method that accurately portrays these impairments in an ecologically valid state. The investigators aim therefore to explore brain function during complex walking in healthy and APD by investigating the effects of age and neurological disease on motor-cognitive performance and its neural correlates during three conditions of complex walking (dual-task walking, navigation and a combination of both) using non-invasive measures of brain activity (functional near infrared spectrometry, fNIRS) and advanced gait analysis in real time in older healthy adults and people with APD.

Вмешательства

• Другое Assessment of brain activity with fNIRS and behavioural assessments (motor, motor-cognitive and cognitive) during three complex walking conditions.
  Dual-task walking with the auditory stroop task. Navigational walking - a course consisting of a distribution of 45 and 90 degrees turns to the left and right Navigational and dual-task walking (condition 1 and 2 together)

Первичные конечные точки

• Functional near infrared spectrometry (fNIRS) [Срок оценки: Baseline]
• Gait performance during all conditions [Срок оценки: Baseline]
• Dual-task performance-reaction time [Срок оценки: Baseline]

Вторичные конечные точки (12)

• Resting-state functional near infrared spectrometry (rsfNIRS) [Срок оценки: Baseline]
• Cognitive function- composite score [Срок оценки: Baseline]
• Cognitive function - verbal fluency [Срок оценки: Baseline]
• Cognitive function - Attention and psychomotor processing speed [Срок оценки: Baseline]
• Cognitive function - Episodic memory [Срок оценки: Baseline]
• Cognitive function - Inhibition & task-set switching [Срок оценки: Baseline]
• Self-reported level of physical activity [Срок оценки: Baseline]
• Physical activity [Срок оценки: Baseline]
• Motor function/disease severity [Срок оценки: Baseline]
• Balance performance [Срок оценки: Baseline]
• Anxiety and depression [Срок оценки: Baseline]
• Walking ability [Срок оценки: Baseline]

Критерии участия

Критерии включения

• clinical diagnosis of PSP according to Movement Disorder Society (MDS) (2017) or
• MSA according to MDS criteria (2022)
• the ability to walk with or without a mobility device for ≤5 minutes continuously

Критерии исключения

• cognitive difficulties affecting the ability to understand and/or follow verbal/written - instructions
• severe freezing of gait
• Severe hearing or visual impairments that affect participation in the assessments
• Other neurological diseases
• Other diseases that can affect gait or balance.

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Нет

Дизайн исследования

Модель наблюдения

Когортное

Центры проведения

Швеция · 1 центр

• Karolinska Institutet — Solna

Идентификаторы

NCT: NCT06906276 · 4-2452/2024 · 2020-03059

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

Открыть это исследование на ClinicalTrials.gov ↗