Effect of Addition of Pyramidal Exercise to Intermittent Fasting on Dryness of Eye in Pre-diabetic Psoriasis Patients

Обзор

insulin resistant psoriatic obese patients may complain problems of dryness of eye. Intermittent fasting may improve dryness of eye, obesity, insulin resistance, and psoriasis. Exercise, as applied in pyramidal form, if added to intermittent fasting may improve effect of intermittent fasting.

Подробное описание

forty obese patients with dryness of eye, obesity, insulin resistance (prediabetes), and psoriasis (chronic plaque) will randomly distributed to group I (n =20 patients) or group II (n=20). Both groups will receive The intermittent fasting regimen consisted of eating ad libitum for five days and then will restrict calories ('fasting') for two days per week, for a duration of 12 weeks. On the fasting days, participants will be instructed to restrict their calories to a maximum of 600 kcal/day for females and 650 kcal/day for males.

The intermittent fasting intervention will consist of a dietary intervention based on the 5:2 fasting diet. Subjects will be asked to consume a total of allowed calories in a window of 6 hours or less from 8:00 am till 2:00 pm, twice per week on 2 non-consecutive days.

Group I will receive a pyramidal training will be adopted for nearly 60 minutes (nearly two rounds of 21 minutes of running on electronic treadmill will be separated with 10 minutes of rest between the two rounds. Also, warming (4 minutes before start of pyrimidal trianing) and cooling (4 minutes after pyramidal training) will be done through gentle stretching exercises/activities. the exercise will be applied 3 times weekly for 2 weeks

Вмешательства

• Поведенческое pyramidal training plus intermittent fasting
  twenty obese patients with dryness of eye, obesity, (prediabetes), and psoriasis will receive intermittent fasting consisted of eating ad libitum for 5 days and then will restrict calories ('fasting') for two days weekly, for 12 weeks. On the fasting days, participants will restrict calories to a maximum of 600 kcal/day for females and 650 kcal/day for males. The dietary intervention will be based on the 5:2 fasting diet. Subjects will be asked to consume a total of allowed calories in a window
• Поведенческое intermittent fasting
  twenty obese patients with dryness of eye, obesity, (prediabetes), and psoriasis will receive intermittent fasting consisted of eating ad libitum for 5 days and then will restrict calories ('fasting') for two days weekly, for 12 weeks. On the fasting days, participants will restrict calories to a maximum of 600 kcal/day for females and 650 kcal/day for males. The dietary intervention will be based on the 5:2 fasting diet. Subjects will be asked to consume a total of allowed calories in a window

Первичные конечные точки

• schrimer test [Срок оценки: it will be assessed after 12 weeks]

Вторичные конечные точки (8)

• Tear film break-up timing [Срок оценки: it will be assessed after 12 weeks]
• System of Dry eye scoring [Срок оценки: it will be assessed after 12 weeks]
• Ocular surface disability index [Срок оценки: it will be assessed after 12 weeks]
• Dermatology life quality index [Срок оценки: it will be assessed after 12 weeks]
• Psoriasis area and severity index [Срок оценки: it will be assessed after 12 weeks]
• Fasting serum blood glucose [Срок оценки: it will be assessed after 12 weeks]
• Waist circumference [Срок оценки: it will be assessed after 12 weeks]
• Body mass index [Срок оценки: it will be assessed after 12 weeks]

Критерии участия

Критерии включения

• chronic plaque psoriasis
• obesity class I
• prediabetic persons
• dryness of both eyes

Критерии исключения

• cardiac insults
• respiratory insults
• diabetics hypertensives or renal, hepatic insults

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Нет

Дизайн исследования

Распределение

Рандомизированное

Модель

Параллельные группы

Маскирование

Простое слепое

Основная цель

Лечение

Центры проведения

Египет · 1 центр

• Faculty of physical therapy — Giza

Идентификаторы

NCT: NCT06893913 · P.T.REC/012/004789

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

Открыть это исследование на ClinicalTrials.gov ↗