Набор скоро начнётся NCT06870890

Impact of Sarcopenia on Dyspnea in Patients With Asthma

Без фазы С лечением Sarcopenia Asthma Dyspnea Dyspnea; Asthmatic

Ориентир для пациента и семьи

Простыми словами

Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.

Что изучают: В протоколе указаны: muscle evaluation, Dosage, Cardiopulmonary exercise test, Questionnaire and Physical Exam.
Кому может быть актуально: Состояния в реестре: Sarcopenia, Asthma, Dyspnea, Dyspnea; Asthmatic. Базовые параметры: от 18 лет · Все.
Что важно проверить: Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
Где проводится: Франция
Следующий шаг: Сохраните исследование, покажите его лечащему врачу и уточните актуальный статус у исследовательского центра. Расходы, документы и поездка →

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Обзор

Dyspnea in asthma, is mainly due to airway obstruction but can be caused by several alternative diagnoses. The impact of sarcopenia on dyspnea in patients with asthma is unknown. Sarcopenic asthma had a reduced physical activity and is associated with airway obstruction compared to non-sarcopenic asthma. In patients with obstructive pulmonary disease, sarcopenia is associated with shallow breathing and diverse sensory and affective components of exertional dyspnea . The morbidity of sarcopenia is also increased by systemic inflammation and the production of inflammatory cytokines as found in inflammatory airway obstruction. The investigators will investigate the prevalence and impact of sarcopenia in asthmatics patients. This will enable to better manage sarcopenia in asthmatic patients, understand its origins and personalize treatment.

Вмешательства

Диагностический тест muscle evaluation
The investigators will evaluate the muscle mass and muscle strenght for all patients included
Биопрепарат Dosage
Evaluation of the cinetic of biomarkers during exercise
Диагностический тест Cardiopulmonary exercise test
CPET
Комбинированный продукт Questionnaire and Physical Exam
Evaluating dyspnea, anxiety, sleep, physical activity, quality of life

Первичные конечные точки

Variation in the intensity of dyspnea during exercise mesured with Borg scale (0-10) according to the presence of sarcopenia [Срок оценки: From baseline (at rest) to the end of the exercise]

Вторичные конечные точки (4)

Variation in exercise-induced release of biomarkers according to the presence of sarcopenia [Срок оценки: at rest = baseline / right after the end of exercice / 45 minutes after the end of exercice]
Difference in muscle mass (kg) on impedancemetry according to the presence of sarcopenia [Срок оценки: Baseline]
Difference on maximum aerobic capacity (VO2 max in L/mn) , according to the presence of sarcopenia [Срок оценки: immediately after the exercise test]
Difference in fat mass (kg) on impedancemetry according to the presence of sarcopenia [Срок оценки: At baseline]

Критерии участия

Критерии включения

Age ≥ 18 years
Patient affiliated to a social security scheme.
Patient capable of giving free, informed, written and signed consent.
Asthmatic patients with a diagnosis made by a pulmonologist on GINA level 4 or 5 treatment
ACT asthma control score < 20
Patient judged by the investigator to be able to to perform a maximal exercise test.