Do Emotions and Pain Combined Affect Mechanical Pain Thresholds and Other Pain-related Variables in Individuals with Chronic Pain?

Обзор

The purpose of this study is to investigate if different emotional states could influence mechanical pain thresholds and other pain - related variables such as pain tolerance, pain intensity and pain - related negative affect in individuals with chronic pain.

Подробное описание

Participants with chronic pain will be randomized into 4 different groups watching different short video-clips (2.20 min), while at the same time experience short-lasting, experimentally induced pain. The negative emotions group will watch an uncomfortable short video containing violence and blood, the positive emotions group will watch a video containing a stand-up comedy show, the neutral emotions group will watch a video about how to paint a house, and the control group will just wait for 2.20 min, without any instructions about what to think about. Pressure pain thresholds, pain tolerance, pain intensity and pain-related negative affect will be measured with an algometer before and after the video-clip combined with experimental pain interventions.

Вмешательства

• Другое Emotional intervention
  Emotional intervention Description: The participant will watch a short video-clip with negative emotional content while simultaneously experience experimentally induced pain.
• Другое Emotional intervention
  Description: The participant will watch a short video-clip with positive emotional content while simultaneously experience experimentally induced pain.
• Другое Emotional intervention
  Description: The participant will watch a short video-clip with neutral emotional content while simultaneously experience experimentally induced pain.

Первичные конечные точки

• Pressure pain thresholds [Срок оценки: Day 1: baseline PPTs are measured, intervention 2.20 min follows and intervention PPTs are measured directly after the intervention. Recruitment for single appointments for each participant will take place for 4 months.]

Вторичные конечные точки (3)

• Pain tolerance (time in seconds the left hand is immersed in cold water 1 degree C). [Срок оценки: Day 1: During a single session (30 min), the participant will keep their hand immersed in cold water for as long as possible while watching a video. This time will be measured in seconds.]
• Pain intensity on the NRS [Срок оценки: Day 1: Pain intensity will be estimated at single session appointments (30 min) on the NRS (Numerical Rating Scale) after the intervention. Participants will be successively recruited for single session appointments for 4 months.]
• Pain-related negative affect on the NRS-A [Срок оценки: Day 1: Pain intensity will be estimated at single session appointments (30 min) on the NRS-A (Numerical Rating Scale-Anxiety) after the intervention. Participants will be successively recruited for single session appointments for 4 months.]

Критерии участия

Критерии включения

• Above 18 years of age
• Fluent in Swedish
• Persistent chronic pain with duration > 6 months

Критерии исключения

\- Known neurological disease

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Нет

Дизайн исследования

Распределение

Рандомизированное

Модель

Параллельные группы

Маскирование

Открытое

Основная цель

Фундаментальное исследование

Центры проведения

Список центров уточняется — проверьте первичный протокол.

Идентификаторы

NCT: NCT06851208 · 2024-07781-01 ethic approval

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

Открыть это исследование на ClinicalTrials.gov ↗