Inflammatory and Metabolic Prognostic Assessment in Critically Ill Neurological Patients

A multi-center, prospective case data collection study will be conducted across 19 tertiary hospitals in China. Based on this, a predictive assessment model for poor prognosis in neurocritically ill patients receiving enteral nutrition support will be developed and validated, using key inflammatory and metabolic markers. During the data collection process, comprehensive clinical information will be extracted, including patient demographic data, clinical indicators, and hematological markers. By conducting in-depth analysis and processing of this vast and detailed clinical and laboratory data, a nomogram for predicting poor prognosis in neurocritical care patients receiving enteral nutrition support will be constructed using statistical methods and data analysis techniques in R. Once the model is built, it will undergo rigorous validation on an independent external dataset to ensure its accuracy and reliability. The goal is to create a precise assessment tool for clinicians, helping them to quickly and accurately identify high-nutritional-risk patients, thereby providing a solid scientific foundation for the formulation of individualized nutrition support strategies, ultimately improving the prognosis of neurocritical patients.

• Nutritional goal achievement rate at Day 3 (caloric and protein intake reaching 70%-100% of calculated target) [Срок оценки: At Day 3 after the initiation of enteral nutrition]
• Adverse outcome rate at Day 90 (defined as a Modified Rankin Scale score ≥ 3) [Срок оценки: At Day 90 after the initiation of enteral nutrition]
• Incidence of infectious complications within 14 days (including pneumonia, urinary tract infections, bloodstream infections, skin infections, and Clostridium difficile infections) [Срок оценки: Within 14 days after the initiation of enteral nutrition]
• Gastrointestinal intolerance within 14 days (gastric residual volume > 200 mL, nausea, vomiting, bloating, diarrhea) [Срок оценки: Within 14 days after the initiation of enteral nutrition]
• Incidence of gastrointestinal bleeding within 14 days (gastric occult blood, fecal occult blood, hematemesis, melena, hematochezia) [Срок оценки: Within 14 days after the initiation of enteral nutrition]
• Number of days with random blood glucose > 10 mmol/L within 14 days [Срок оценки: Within 14 days after the initiation of enteral nutrition]
• Average daily insulin requirement within 14 days [Срок оценки: Within 14 days after the initiation of enteral nutrition]
• Incidence of hypophosphatemia within 3 days [Срок оценки: Within 3 days after the initiation of enteral nutrition]
• Duration of mechanical ventilation within 14 days [Срок оценки: Within 14 days after the initiation of enteral nutrition]
• Length of NICU stay [Срок оценки: From enrollment to discharge from the NICU, up to 1 year.]
• Total hospital stay duration [Срок оценки: From enrollment to discharge, up to 1 year.]
• 90-day readmission rate post-discharge [Срок оценки: Within 90 days after discharge]