Caries-associated Saliva Biomarkers Among Different Races

Официальное название

Caries-associated Saliva Biomarkers in Caries Experienced and Caries Free Population Among Different Races: Diagnostic Accuracy Study

Обзор

discover possible differences and develop effective preventative interventions by examining the relationship between salivary biomarkers and caries prevalence across different racial groups and Detect risk factors involved in caries incidence .

Подробное описание

Dental caries is a multifactorial condition that is influenced by both external and internal variables. Tooth decay progression is directly influenced by host factors, including the individual's immune competence, saliva flow rate and buffering capacity, tooth form, and bacterial makeup .

While salivary biomarkers are essential for predicting the risk of dental caries, little is known about how they relate to caries in a variety of populations. By examining the relationship between salivary biomarkers and caries prevalence across several racial groups, this study seeks to close this gap and enhance culturally appropriate preventive approaches . There have been contentious discussions over the causes of differences in oral health during the past forty years. The term "structural inequities" refers to the social, environmental, economic, and cultural determinants of health, which are frequently impacted by racial or ethnic background, gender, work status, immigrant status, and geographic location. Racialized populations have demonstrated greater rates of untreated dental decay (caries), severe periodontal disease, and total or partial edentulism . Typically, "race" refers to an individual's physical characteristics, such as skin tone or hair type, which may indicate their ancestry. White, African American, or Asian descent are some examples of classifications that are frequently used to characterize race .

Вмешательства

• Диагностический тест Salivary biomarkers tests
  saliva samples are collected from participants

Первичные конечные точки

• the patient has caries or not according to ELISA and colorimetric assay [Срок оценки: 3 months]

Критерии участия

Критерии включения

• Age : 19-25
• We will have 2 groups according to ICDAS classification : Not severe (ICDAS score ≤3) / Severe (ICDAS score ≥3)

Критерии исключения

• : Those who reported daily use of alcohol or tobacco .
• Those who used antibiotics or other systemic drugs within the previous three months .
• Those who regularly used antiseptics

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Да

Дизайн исследования

Модель наблюдения

Другое

Центры проведения

Список центров уточняется — проверьте первичный протокол.

Публикации

• Abdinian M, Razavi SM, Faghihian R, Samety AA, Faghihian E. Accuracy of Digital Bitewing Radiography versus Different Views of Digital Panoramic Radiography for Detection of Proximal Caries. J Dent (Tehran). 2015 Apr;12(4):290-7. PMID 26622284
• Barreto ML. Health inequalities: a global perspective. Cien Saude Colet. 2017 Jul;22(7):2097-2108. doi: 10.1590/1413-81232017227.02742017. English, Portuguese, Spanish. PMID 28723991
• Beckfield J, Olafsdottir S. Health Inequalities in Global Context. Am Behav Sci. 2013;57(8):1014-1039. doi: 10.1177/0002764213487343. Epub 2013 Jun 26. PMID 29104292
• Cash-Gibson L, Rojas-Gualdron DF, Pericas JM, Benach J. Inequalities in global health inequalities research: A 50-year bibliometric analysis (1966-2015). PLoS One. 2018 Jan 31;13(1):e0191901. doi: 10.1371/journal.pone.0191901. eCollection 2018. PMID 29385197
• Daley S, Nugent A, Taylor GD. Dental divisions: exploring racial inequities of dental caries amongst children. Evid Based Dent. 2024 Mar;25(1):41-42. doi: 10.1038/s41432-024-00977-w. Epub 2024 Jan 26. PMID 38279035
• Han C. Oral health disparities: Racial, language and nativity effects. SSM Popul Health. 2019 Jun 21;8:100436. doi: 10.1016/j.ssmph.2019.100436. eCollection 2019 Aug. PMID 31372488
• Havsed K, Carda-Dieguez M, Isaksson H, Stensson M, Carlsson E, Jansson H, Malmodin D, Nord AB, Wickstrom C, Mira A. Salivary Proteins and Metabolites as Caries Biomarkers in Adolescents. Caries Res. 2024;58(6):573-588. doi: 10.1159/000540090. Epub 2024 Jul 17. PMID 38972309
• Nath S, Poirier B, Ju X, Kapellas K, Haag D, Jamieson L. Periodontal disease inequities among Indigenous populations: A systematic review and meta-analysis. J Periodontal Res. 2022 Jan;57(1):11-29. doi: 10.1111/jre.12942. Epub 2021 Oct 16. PMID 34655251

Идентификаторы

NCT: NCT06838182 · Salivary biomarkers and caries

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

Открыть это исследование на ClinicalTrials.gov ↗