The Relationship Between The Differential Expression Of FosB Protein In Laryngeal Cancer Tissues And Clinical Prognosis

Официальное название

Expression Of FosB Gene In Laryngeal Cancer Tissues And It's Clinical Prognosis Significance

Обзор

To determine whether there is statisstical difference in FosB (FBJ murine osteosarcoma viral oncogene homolog B) protein expression between laryngeal cancer tissue and adjacent tissue through immunohistochemistry methods. If there are differences, further the investigators will collect relevant patients information,such as clinical stages, pathological types, clinical prognosis and so on. ultimately analyze whether it is related to the expression of FOsB in laryngeal cancer tissue and adjacent tissues

Подробное описание

First,the investigators will collect 100 to 200 cases of laryngeal cancer patients who have been finally diagnosed and treated in our institution in the past five years. Laryngeal cancer pathological tissues and adjacent tissues will be selected to make pathological sections. Use immunohistochemistry to confirm the differences in FosB protein between laryngeal cancer tissues and adjacent tissues, and clarify whether there are differences.

secondly,if there are differences, further the investigators will collect relevant patients information,such as clinical stages, pathological types, clinical prognosis and so on. Review the clinical data of corresponding patients, including age, gender, smoking and alcohol history, clinical stages, pathological types and clinical prognosis, etc., and compare whether there are statistical differences.

Finally, clinical prognostic data of relevant patients were collected through outpatient follow-up, online and telephone follow-up, to determine whether there is a correlation between Fosb expression in laryngeal cancer tissue and clinical prognosis.

Вмешательства

• Другое the expression negative in laryngeal cancer tissue
  Researcher will incorporate the positive expression of FOSB protein in laryngeal cancer tissues into the positive study group and vice versa into the negative study group by immunohistochemical methods!
• Другое the expression positive in laryngeal cancer tissue
  Researcher will incorporate the positive expression of FOSB protein in laryngeal cancer tissues into the positive study group and vice versa into the negative study group by immunohistochemical methods!

Первичные конечные точки

• the number of fosb gene positive expression cases in laryngeal carcinoma cells and adjacent tissues was determined. [Срок оценки: one month]

Вторичные конечные точки (1)

• _Experimental result of western blot and PCR._Correlation analysis data between clinical information and experimental results.. [Срок оценки: three months]

Критерии участия

Критерии включения

• laryngeal squamous cell carcinoma was diagnosed ,and biopsy was confirmed by two pathologists;
• Primary tumor of Laryngeal ,and there was no distant metastasis;
• Standard treatment such as surgery and Preliminarily-diagnosed parients;
• full clinical and pathological data information and good follow-up;
• there was no previous fatal diseases such as complicated tumors.

Критерии исключения

• Secondary cancer or cancer with distant metastasis;
• Patients who have not seen a doctor for the first time or have received surgery or radiotherapy or chemotherapy in other hospitals;
• Clinical and pathological data were missing and loss to follow-up;
• Patients who abandoned treatment or standard treatment procedures has not been completed;
• The past medical history of other lethal diseases such as complicated tumors.

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Нет

Дизайн исследования

Модель наблюдения

Другое

Центры проведения

Китай · 1 центр

• Cllinical Laboratory of Chuanbei Medical College — Nanchong

Публикации

• Liu S, Luan J, Ding Y. miR-144-3p Targets FosB Proto-oncogene, AP-1 Transcription Factor Subunit (FOSB) to Suppress Proliferation, Migration, and Invasion of PANC-1 Pancreatic Cancer Cells. Oncol Res. 2018 Jun 11;26(5):683-690. doi: 10.3727/096504017X14982585511252. Epub 2017 Jun 24. PMID 28653602
• Hung YP, Fletcher CD, Hornick JL. FOSB is a Useful Diagnostic Marker for Pseudomyogenic Hemangioendothelioma. Am J Surg Pathol. 2017 May;41(5):596-606. doi: 10.1097/PAS.0000000000000795. PMID 28009608
• Eferl R, Wagner EF. AP-1: a double-edged sword in tumorigenesis. Nat Rev Cancer. 2003 Nov;3(11):859-68. doi: 10.1038/nrc1209. No abstract available. PMID 14668816

Идентификаторы

NCT: NCT06836765 · NeijiangPH2

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

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