Efficacy of Baduanjin Exercise in COVID-19 Contraction Patients With Idiopathic Chronic Fatigue

Обзор

Post-COVID recovery is associated with reduced functional fitness/capacity, low quality of life, and physical disabilities in those who survived after contracting the disease. The unpleasant symptoms of chronic post-viral/post-COVID syndrome (chronic fatigue perception, variant nonspecific myalgia, bad mood or depression, and insomnia or sleep disturbances) usually magnify the symptoms of already existing previously diagnosed concurrent untreatable chronic disorders , including the idiopathic chronic fatigue (ICF).(Leszczak et al., 2024) Baduanjin exercise training (BET) is one of the Chinese traditional Health-Qigong exercises that not only integrate slow coordinating postures/positions, breathing techniques, musculoskeletal stretching movements/positions, and meditative mind but also plays a strong role concerning health benefits (e.g. musculoskeletal pain-reducing, sleep disturbance-enhancing effects, and fatigue-reducing effects) (Zou et al., 2018).

Подробное описание

forty idiopathic chronic fatigue (ICF) patients will be randomly assigned into two equal groups (n=20)

1. Study group (20 patients) this group will be supervised daily, except Fridays, during the 60-minute session of 12-week BET) or waitlist group 2. Control group (20 patients)

Вмешательства

• Другое Baduanjin exercise training (BET)
  Baduanjin Exercise Training (BET) is a traditional Chinese exercise focused on improving physical health, flexibility, balance, and mental well-being. It involves a 10-minute warm-up, a 40-minute core session practicing eight distinct postures, and a 10-minute cool-down. The postures, based on the Baduanjin form, target different body parts and promote strength, flexibility, and circulation. The exercises are synchronized with deep breathing to enhance relaxation and stress reduction. BET is esp

Первичные конечные точки

• Pulmonary function: By Spirometry Device: [Срок оценки: By Spirometry Device: forced vital capacity will be measured at baseline, and it will be measured after twelve weeks again]

Вторичные конечные точки (10)

• Pulmonary function: By Spirometry Device: [Срок оценки: By Spirometry Device forced expiratory volume in one second (FEV1) will be measured at baseline, and it will be measured after twelve weeks again]
• Measuring functional capacity: By Six-minute walk test (6MWT) [Срок оценки: Measuring functional capacity: By Six-minute walk test (6MWT)::will be measured at baseline, and it will be measured again after twelve weeks]
• Modified Borg dyspnea scale (MBDS) [Срок оценки: Modified Borg dyspnea scale (MBDS) will be measured at baseline, and it will be measured again after twelve weeks]
• Strength of lower limb muscles By a thirty-second sit-to-stand test [Срок оценки: thirty-second sit-to-stand test will be measured at baseline, and it will be measured again after twelve weeks]
• Endurance of upper limb muscles: by the maximal repetitions of push-ups (MRPU). [Срок оценки: the maximal repetitions of push-ups (MRPU). will be measured at baseline, and it will be measured again after twelve weeks]
• Cardiorespiratory fitness:by the index of Ruffier test (IRT). [Срок оценки: Cardiorespiratory fitness:by the index of Ruffier test (IRT). will be measured at baseline, and it will be measured again after twelve weeks]
• Quality of life: by the short form 36 questionnaire (SF) [Срок оценки: Quality of life: by the short form 36 questionnaire (SF) will be measured at baseline, and it will be measured again after twelve weeks]
• sleep quality by Pittsburgh sleep quality index (PSQI): [Срок оценки: sleep quality by Pittsburgh sleep quality index (PSQI):will be measured at baseline, and it will be measured again after twelve weeks]
• Beck Depression Inventory (BDI): [Срок оценки: Beck Depression Inventory (BDI):will be measured at baseline, and it will be measured again after twelve weeks]
• fatigue assessment by Buzhongyiqi-Tang questionnaire (BZTQ): [Срок оценки: Buzhongyiqi-Tang questionnaire (BZTQ)::will be measured at baseline, and it will be measured again after twelve weeks]

Критерии участия

Критерии включения

• • 40 patients will be recruited in the study.

• age ≥ 18 to ≤ 50 years old
• achieved three diagnostic items/criteria of ICF will be included in this BET trial: Fatigue lasting over 6 months, which significantly limits daily activities, reducing the person's usual activity level by more than 50%, as confirmed by a doctor.

At least three of the following symptoms:

Generalized muscle weakness Difficulty sleeping Frequent headaches A painful throat Muscle tenderness throughout the body Migratory joint pain Swollen lymph nodes in the neck or armpits Fatigue lasting more than a day after typical activities

Критерии исключения

• Patients with a history of medical or complementary treatments for ICF disorder in the 6 months before contracting COVID or after recovery.
• Individuals who have engaged in therapeutic exercise, pharmacological treatments, or complementary therapies for post-COVID symptoms within the last six months prior to enrollment.
• ICF patients regularly using antidepressants or antipsychotics were excluded.
• Those who take sleeping pills regularly were also excluded.
• Patients with autoimmune diseases, malignant conditions, anemia, endocrine disorders, systemic diseases, or osteoarthritis affecting the cervical spine, lumbar region, or limbs were excluded.
• Individuals with abnormal results in laboratory tests, including neurological, neurophysiological, cardiological, liver/kidney function tests, or urine/stool analyses (as determined by a physician) were excluded.

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Нет

Дизайн исследования

Распределение

Рандомизированное

Модель

Параллельные группы

Маскирование

Простое слепое

Основная цель

Лечение

Центры проведения

Египет · 1 центр

• Cairo University — Cairo

Идентификаторы

NCT: NCT06829940 · P.T.REC/012/005517

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

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