Меню
Набор по приглашению NCT06829836

Can You Breathe Your Way To Better Health?

Без фазы С лечением Cancer Chronic Stress Autonomic Dysfunction

Ориентир для пациента и семьи

Простыми словами

Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.

Что изучают
В протоколе указаны: Hight intensity interval training, Cyclic Hyperventilation with Retention.
Кому может быть актуально
Состояния в реестре: Cancer, Chronic Stress, Autonomic Dysfunction. Базовые параметры: 18 лет — 50 лет · Все.
Что важно проверить
Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
Где проводится
США
Следующий шаг
Сохраните исследование, покажите его лечащему врачу и уточните актуальный статус у исследовательского центра. Расходы, документы и поездка →

Не всё понятно в терминах? Прочитайте наш гид для пациентов →

Обзор

The purpose of this clinical trial is to explore the effects of either a 2-week high-intensity interval training (HIIT) or breath training intervention on measures of overall health, circulating biomarkers of stress, and immune function. Specific aims include: - Does a 2-week HIIT or breath training intervention improve measurements of overall health, including heart rate variability, physical activity, sleep quality, and severity of depression, anxiety, and stress? -Does a 2-week HIIT or breath training intervention improve circulating concentrations of stress-related biomarkers? Does a 2-week HIIT or breath training intervention improve immune function? Researchers will compare HIIT and breath training to see if equivalent immune improvements are observed. Participants will: -Undergo 2 weeks of HIIT or breath training interventions at a frequency of 3 times per week for 30 minutes or 5 times per week for 5 minutes if placed into an intervention group. -Undergo testing measures at the two pre- and post-intervention time points, if placed in the intervention groups or the healthy control group.

Вмешательства

  • Поведенческое Hight intensity interval training
    Participants assigned to this intervention group will complete 6 supervised HIIT sessions over 2 weeks.
  • Поведенческое Cyclic Hyperventilation with Retention
    Participants of this intervention group will complete a total of 10 remote guided breathing sessions on Zoom over 2 weeks.

Первичные конечные точки

  • Serum Analysis: C-reactive protein (CRP) [Срок оценки: Visit 1(Week 1) and Visit 3 (Week 4): 15 minutes for blood draw. The assay itself takes 3 hours.]
  • Serum Analysis: Brain Derived Neurotrophic Factor (BDNF) [Срок оценки: Visit 1A (Week 1) and Visit 2A (Week 4): 15 minutes for blood draw. The assay itself takes 3 hours.]
  • Natural Killer cell quantity [Срок оценки: Visit 1(Week 1) and Visit 3 (Week 4): 15 minutes for blood draw. The assay itself takes ~10-12 hours.]
  • Natural Killer Cell Cytotoxicity [Срок оценки: Visit 1(Week 1) and Visit 3 (Week 4): 15 minutes for blood draw. The assay itself takes ~10-12 hours.]
  • Heart Rate Variability (HRV) [Срок оценки: Visit 2 (week 1) and Vist 4 (week 4)]
Вторичные конечные точки (6)
  • Physical Activity Readiness Questionnaire for Everyone (PAR-Q+) [Срок оценки: Visit 1 (week 1) 10 minutes]
  • Depression Anxiety and Stress Scale (DASS-21) [Срок оценки: Visit 1 (week 1) and Visit 3 (week 4) 10 minutes each]
  • Pittsburg Sleep Quality Index (PSQI) [Срок оценки: Visit 1 (week 1) and Visit 3 (week 4) 10 minutes each]
  • Wisconsin Upper Respiratory Symptom Survey (WURSS-21) [Срок оценки: Visit 1 (week 1) and Visit 3 (week 4) 10 minutes each]
  • Physical Activity and Sleep Tracking [Срок оценки: 4 weeks]
  • VO2Max [Срок оценки: Visit 2 (week 1) 30-45 minutes]

Критерии участия

Критерии включения

  • Age, 18-50 years
  • Sex, Male and Female
  • Informed Consent, The capability and willingness to give written informed consent to understand the exclusion criteria and to accept the randomized group assignment is required.
  • PAR-Q+, The capability and willingness to complete the physical activity readiness questionnaire, with no medical clearance needed.
  • Physical Activity: Participants must refrain from regular HIIT and structured breathing practices for a month before participation
  • Depression, Anxiety, and Stress Scale, Subcategory Scoring (DASS-21) Participants must score in the mild or greater category for Depression, Anxiety, and Stress. Depression ≥ 10, Anxiety ≥ 8, and Stress ≥ 14.

Критерии исключения

  • Age: Individuals under 18 years and over 50 years
  • Significant Respiratory Conditions, including but not limited to asthma, chronic obstructive pulmonary disease,
  • Significant Cardiovascular Disease: Participants with a known cardiovascular condition such as a previous myocardial infarction, congestive heart failure, stroke, or transient ischemic attack, cardiomyopathy, serious arrhythmia, peripheral vascular disease, untreated atherosclerosis, or hypertension.
  • Significant Musculoskeletal Disease, including but not limited to osteopenia, osteoporosis, rheumatoid arthritis, and sarcopenia
  • Cognitive and Mental Health, including but not limited to untreated anxiety, untreated depression, post-traumatic stress disorder, and thoughts of suicide.

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Да

Дизайн исследования

Распределение
Рандомизированное
Модель
Параллельные группы
Маскирование
Открытое
Основная цель
Организация здравоохранения

Центры проведения

США · 1 центр
  • University of Northern Colorado, 1610 Gunter Hall, 1828 10th Ave, Greeley, CO 80631 — Greeley

Идентификаторы

NCT: NCT06829836 · 2404058931

Первоисточники (государственные реестры)

Открыть это исследование на ClinicalTrials.gov ↗