Surveillance of AMR in DRC

Официальное название

Surveillance of Antimicrobial Resistance in Semirural Kinshasa, Democratic Republic of Congo: a Feasibility Study

Обзор

This study addresses knowledge gaps regarding antimicrobial resistance (AMR) in sub-Saharan Africa, focusing on evaluating the feasibility of AMR surveillance and enhancing local research capacity. Conducted at a general referral hospital in semirural Kinshasa, DRC, the study will investigate bacterial infections, their resistance profiles, and related risk factors, including co-infections such as malaria.

Подробное описание

Antimicrobial resistance (AMR) is a significant global health threat, but its full impact in many African regions is still poorly understood. In collaboration with the Kinshasa School of Public Health, the Institut National de la Recherche Biomédicale (INRB) of DRC, and the University of Oxford, this study will assess the feasibility of implementing AMR surveillance in a general referral hospital in semirural Kinshasa, where onsite microbiological testing is currently unavailable. A key objective is to strengthen local research capacity by training staff in patient identification and specimen collection for AMR surveillance. The study will include patients over six months of age with suspected bloodstream infections at the time of hospital admission who agree to participate and from whom informed consent has been obtained. The focus is on community-acquired infections, excluding patients with significant prior healthcare or antibiotic exposure. Blood samples will be analyzed at INRB to determine the bacterial cause of infections, evaluate antimicrobial resistance levels, and identify associated risk factors, including co-infection with Plasmodium falciparum. Study results will be shared promptly with the hospital team to aid in patient management. Participants will be followed up for 28 days post-admission.

Первичные конечные точки

• Recruitment process [Срок оценки: Duration of recruitment, about six months]
• Intervention delivery [Срок оценки: Duration of recruitment, about six months]
• Processing time [Срок оценки: Duration of recruitment, about six months]
• Number of Bacterial Bloodstream Infections [Срок оценки: Duration of recruitment, about 6 months]
• Antimicrobial Susceptibility [Срок оценки: Duration of recruitment, about six months]
• Co-infection [Срок оценки: Duration of recruitment, about six months]
• Outcome [Срок оценки: Study duration, plus 4 weeks]

Критерии участия

Patients older than six months who present with a clinically suspected bloodstream infection upon admission to the hospital, or who have been hospitalized for less than 48 hours, and provide written consent (or consent from their caregiver/legal guardian) to participate will be included. Patients with a significant history of healthcare exposure and those with any contraindications for phlebotomy as determined by the clinician's judgment, will be excluded.

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Нет

Дизайн исследования

Модель наблюдения

Только случаи

Центры проведения

Democratic Republic of the Congo · 1 центр

• Kinshasa, Democratic Republic of Congo, Kinshasa School of Public Health — Kinshasa

Идентификаторы

NCT: NCT06821282 · MID24001

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

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