Optimizing Strength Training in Older Adults

Обзор

The objective of the current study is to determine whether lifting lighter loads close to failure improves strength training adaptations and function in older adults. The main questions it aims to answer are: 1. The effect of light loads on physical function 2. The effect of light loads on muscle mass, power, and strength Researchers will compare a light-load, high-repetition program to a standard strength training program. Participants will perform supervised strength training twice per week for 20 weeks.

Вмешательства

• Поведенческое Strength training
  This intervention involves strength training with lighter loads and higher repetitions.
• Поведенческое Strength training
  This intervention involves conventional strength training with higher loads and moderate repetitions.

Первичные конечные точки

• 6-minute walk test [Срок оценки: Baseline and week 21]

Вторичные конечные точки (10)

• Lower body maximal muscle strength [Срок оценки: Baseline and week 21.]
• Lower body muscle power [Срок оценки: Baseline and week 21]
• Lean body mass (LBM) [Срок оценки: Baseline and week 21]
• Self-reported physical function [Срок оценки: Baseline and week 21]
• Get-up & go test [Срок оценки: Baseline and week 21]
• 30-second chair stand test [Срок оценки: Baseline and week 21]
• Number of participants with adverse events [Срок оценки: From enrollment to the end of 20-week intervention period]
• Physical activity enjoyment scale (PACES) [Срок оценки: Week 21]
• Exercise self-efficacy questionnaire [Срок оценки: Week 21]
• Exercise session attendance [Срок оценки: From enrollment to the end of 20-week intervention period]

Критерии участия

Критерии включения

• Males and females aged 65 years and above
• Inactive lifestyle (< 150 min per week of moderate intensity physical activity) and not regularly participating in a structured strength training program
• Planning to reside in the area for the duration of the study

Критерии исключения

• Severe cardiac disease, including Class III or IV congestive heart failure, clinically significant aortic stenosis, history of cardiac arrest, use of a cardiac defibrillator, or uncontrolled angina
• Lung disease requiring either oral or injected steroids, or the use of supplemental oxygen
• Short, portable mental status questionnaire with 3 or more errors
• Severe arthritis (either osteoarthritis or rheumatoid arthritis)
• Cancer requiring treatment in the past 1 year (melanomas excluded)
• Development of chest pain or severe shortness of breath during the 6 min self-paced walk test
• Parkinson's disease or other serious neurological disorders
• Renal disease requiring dialysis
• Current diagnosis of schizophrenia, other psychotic disorders, or bipolar disorder
• Current consumption of more than 14 alcoholic drinks per week
• Severe lower back or shoulder pain that may worsen with weightlifting exercises
• Undergoing physical therapy involving the lower extremities
• Living in nursing homes, assisted living facilities or other similar institutions
• Currently enrolled in another randomized trial involving a pharmaceutical or lifestyle intervention
• Weight change (intentional or not) over the last 6 months of > 5% of body weight, or plan to lose or gain weight during the study
• Any other cardiovascular, pulmonary, orthopedic, neurologic, or other conditions that would preclude participation and successful completion of the protocol

Temporary Exclusion Criteria

A person meeting any of the following temporary exclusion criteria at the time of screening will not be enrolled but may be re-screened later.

• Severe hypertension, e.g., SBP > 200 mm Hg, DBP > 110 mm Hg
• Major surgery or fracture or hip/knee replacement within the last 6 months
• Hospitalization within the last 6 months (excluding ER visits)

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Да

Дизайн исследования

Распределение

Рандомизированное

Модель

Параллельные группы

Маскирование

Простое слепое

Основная цель

Другое

Центры проведения

США · 1 центр

• Exercise & Aging Lab, Queens College — Flushing

Публикации

• T Balachandran A, Wang Y, Szabo F, Watts-Battey C, Schoenfeld BJ, Zenko Z, Quiles N. Comparison of traditional vs. lighter load strength training on fat-free mass, strength, power and affective responses in middle and older-aged adults: A pilot randomized trial. Exp Gerontol. 2023 Jul;178:112219. doi: 10.1016/j.exger.2023.112219. Epub 2023 May 30. PMID 37236327

Идентификаторы

NCT: NCT06812143 · R15AG085170 · 1R15AG085170-01

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

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