Effects of Exercise in Patients with Lipedema

Официальное название

Effects of Exercise on Edema, Pain, Exercise Capacity, Lower Extremity Muscle Strength and Function in Patients with Lipedema

Обзор

Lipedema is a chronic progressive disease characterized by symmetrical, disproportionate swelling of subcutaneous adipose tissue, which is common in women and mostly seen in the lower extremities and to a lesser extent in the upper extremities. Healthy lifestyle approaches including exercise treatments are very important for lipedema patients in order to prevent disease progression. The aim of this study is to investigate the effects of exercise on edema, pain, exercise capacity, lower extremity muscle strength and function in lipedema patients. Sociodemographic information of the patients, body composition with Tanita InnerScan BC-601-CG device, clinical information regarding lipedema, type and stage of lipedema, inspection, palpation findings will be recorded. Local tissue water percentage will be assessed using Moisturemeter-d compact (MMDc, Delfin Technologies, Kuopio, Finland) device, circumference measurement using tape, pain intensity with Visual Analog Scale, pain threshold with Baseline brand digital algometer device. Muscle strength will be assessed using K-Force hand dynamometer. Functional exercise capacity will be assessed with the 6-minute walk test (6MWT), and lower extremity dysfunction with the lower extremity functional scale. After the assessments are made, the patients will be randomly divided into 2 groups. The patients in the study group will perform group exercises consisting of warm-up, loading and cool-down periods of 40-50 minutes, 2 days a week for 6 weeks, and strengthening exercises applied to the hip muscles and knee extensors with elastic resistance bands, which are decided according to the level of effort perceived by the patient, 3 sets of 10 repetitions, 2 days a week for 6 weeks. The same assessments will be applied to the patients again at the end of the exercise program. The control group will be re-evaluated after 6 weeks with suggestions regarding lipedema and physical activity level, and the obtained data will be compared.

Вмешательства

• Поведенческое Exercise
  Patients with lipedema will perform group exercises consisting of warm-up, loading and cool-down periods of 40-50 minutes, 2 days a week for 6 weeks, and strengthening exercises applied to the muscles around the hips and knee extensors with elastic resistance bands, determined according to the effort level perceived by the patient, 3 sets of 10 repetitions, 2 days a week for 6 weeks.
• Поведенческое Physical activity
  The control group will be given recommendations regarding lipedema and physical activity level.

Первичные конечные точки

• Local tissue water percentage [Срок оценки: 6 weeks]
• edema [Срок оценки: 6 weeks]
• Pain severity [Срок оценки: 6 weeks]
• Pain Threshold [Срок оценки: 6 weeks]
• Lower extremity muscle strength [Срок оценки: 6 weeks]
• Lower extremity muscle endurance [Срок оценки: 6 weeks]
• functional exercise capacity [Срок оценки: 6 weeks]
• lower extremity function [Срок оценки: 6 weeks]

Критерии участия

Критерии включения

• Having a diagnosis of Lipedema,
• Patients with Lipedema stage 1,2 and 3

Критерии исключения

• Individuals with cardiopulmonary, rheumatic or neurological diagnoses that have symptoms severe enough to prevent participation in exercise,
• History of cancer, surgery or trauma that may affect the circulatory system,
• History of liposuction or orthopedic surgery within the last year,
• Individuals who cannot mobilize independently.

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Нет

Дизайн исследования

Распределение

Рандомизированное

Модель

Параллельные группы

Маскирование

Открытое

Основная цель

Лечение

Центры проведения

Turkey (Türkiye) · 1 центр

• Gazi University Faculty of Health Sciences — Ankara

Публикации

• Sakizli Erdal E, Ergin C, Haspolat M, Erturk B, Keser I. Effects of multimodal exercise program on edema, pain, exercise capacity, lower extremity muscle strength and function in patients with lipedema. Phlebology. 2026 Feb;41(1):47-57. doi: 10.1177/02683555251343148. Epub 2025 May 15. PMID 40372970

Идентификаторы

NCT: NCT06811961 · ElifSakizliLipedema

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

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