A Phase III Clinical Trial Evaluating the Efficacy and Safety of Valsartan/Levamlodipine (SYH9056) Tablets In Hypertensive Patients

Официальное название

A Multicenter, Randomized, Double-Blind Phase III Clinical Trial Evaluating the Efficacy and Safety of Valsartan/Levamlodipine (SYH9056) Tablets in Patients With Mild to Moderate Essential Hypertension Not Controlled After 4 Weeks of Monotherapy With Amlodipine Or Levamlodipine Alone

Обзор

SYH9056 tablets are a combination of valsartan and levamlodipine maleate. This is a multicenter, randomized, double-blind, parallel-controlled phase III study, designed to validate the efficacy and safety of SYH9056 tablets in patients with mild-to-moderate essential hypertension not controlled after 4 weeks of treatment with either levamlodipine maleate tablets or valsartan capsules, using either levamlodipine maleate tablets or valsartan capsules as a control. The study consisted of 4 phases: a screening period (2 weeks), an introduction period (4 weeks), a core treatment period (12 weeks), an extended treatment period (12 weeks), and a safety follow-up period (1 week), totaling approximately 31 weeks.

Вмешательства

• Препарат SYH9056
  PO once daily, 1 tablet each time, each tablet contains 2.5mg levamlodipine and 80mg valsartan
• Препарат Levamlodipine
  2.5mg PO once daily
• Препарат Valsartan
  80mg PO once daily
• Препарат SYH9056 placebo
  PO once daily
• Препарат Levamlodipine placebo
  PO once daily
• Препарат valsartan placebo
  PO once daily

Первичные конечные точки

• Absolute change from baseline in mean sitting systolic blood pressure at Week 12 [Срок оценки: At Week 12]

Критерии участия

Критерии включения

• 18-75 (inclusive) years old;
• 18.0 kg/m\^2 ≤ BMI ≤ 35.0 kg/m\^2 and ≥ 50 kg for men and ≥ 45 kg for women at screening;
• Diagnosis of mild or moderate essential hypertension;
• Office blood pressure measurements meet any of the following at the time of screening:

① Patients who have not used any antihypertensive medication for at least 4 weeks prior to screening, with an average office sitting blood pressure (average of 3 measurements) of 150 mmHg ≤ SBP < 180 mmHg and DBP < 110 mmHg;

② Patients who have been using a stable dose of one or two component of antihypertensive medications (including single agents, two-drug combination or two-component combinations) for at least 4 weeks prior to screening, and who, in the judgment of the clinician, can be switched to levlevamlodipine maleate tablets (2.5 mg/day) or valacyclovir capsules (80 mg/day), and whose mean office sitting blood pressure meets 140 mmHg ≤ SBP < 180 mmHg and DBP < 110 mmHg;

• Prior to randomization, mean office sitting blood pressure meets 140 mmHg ≤ SBP < 180 mmHg and DBP < 110 mmHg;
• Medication adherence between 80% and 120% (including borderline values) during the introductory period.

Критерии исключения

• Rrefractory hypertension, hypertensive emergencies, hypertensive sub-emergencies and secondary hypertension;
• Allergy (≥ 3 drug or food allergies) or known hypersensitivity to levamlodipine, levlevamlodipine, valsartan and related drugs (dihydropyridine calcium channel blockers, angiotensin II receptor blockers);
• History of malignancy within the last 5 years (with the exception of cured basal cell carcinoma of the skin, limited squamous cell carcinoma of the skin, or cervical cancer in situ), or an underlying malignancy currently under evaluation;
• Known or suspected symptomatic upright/postural hypotension ;
• Uncontrolled diabetes mellitus;
• Abnormal thyroid function;
• Severe cardiovascular or cerebrovascular disease within 6 months prior to screening or randomization.

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Нет

Дизайн исследования

Распределение

Рандомизированное

Модель

Параллельные группы

Маскирование

Четверное слепое

Основная цель

Лечение

Центры проведения

Список центров уточняется — проверьте первичный протокол.

Идентификаторы

NCT: NCT06771245 · SYH9056-002

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

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