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Идёт набор NCT06769672

Dual-task Training Combined With tDCS on Cognitive-motor Performance and Brain Activity in Stroke Patients

Без фазы С лечением Stroke Cortical Excitability

Ориентир для пациента и семьи

Простыми словами

Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.

Что изучают
В протоколе указаны: active tDCS with dual-task training, sham tDCS with dual-task training.
Кому может быть актуально
Состояния в реестре: Stroke, Cortical Excitability. Базовые параметры: от 50 лет · Все.
Что важно проверить
Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
Где проводится
Гонконг
Следующий шаг
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Официальное название

The Effect of Dual-task Training Combined With tDCS on Cognitive-motor Interference and Related Brain Activity in Stroke Patients

Обзор

The purpose of this study is to evaluate tDCS combined with cognitive-motor training on dual-task interference during dual-task walking, dual-task foot pedaling and the corresponding alterations of brain activity.

Подробное описание

In China, the prevalence of stroke increased by 106.0% (93.7-118.8) between 1990 and 2019, highlighting the persistent and substantial burden of this condition. Post-stroke recovery, particularly the ability to achieve community ambulation, plays a critical role in improving health-related quality of life. Effective community ambulation in daily life requires the ability to dual-task-namely, to perform concurrent tasks requiring attentional resources while maintaining walking function and balance. Emerging evidence suggests that stroke survivors face greater challenges in walking function and dual-task balance compared to their age-matched, able-bodied counterparts. For instance, when tasked with recalling a shopping list while walking, stroke patients exhibit a more pronounced decline in both walking speed and cognitive performance relative to control groups. Given the necessity for stroke survivors to reintegrate into the community, it is imperative to thoroughly investigate this phenomenon of cognitive-motor interference.

Вмешательства

  • Другое active tDCS with dual-task training
    participants receive three 20-minute active tDCS treatment and three 60-minute COGMOTION dual-task exercise sessions per week for four consecutive weeks.
  • Другое sham tDCS with dual-task training
    participants receive three 20-minute sham tDCS treatment and three 60-minute COGMOTION dual-task exercise sessions per week for four consecutive weeks.

Первичные конечные точки

  • Dual-task gait speed [Срок оценки: Through study completion, an average of 1 year]
  • Dual-task cognitive performance [Срок оценки: Through study completion, an average of 1 year]
Вторичные конечные точки (9)
  • Oxyhemoglobin concentration changes of the brain [Срок оценки: Through study completion, an average of 1 year]
  • Dual-task gait performance 1 [Срок оценки: Through study completion, an average of 1 year]
  • Dual-task gait performance 2 [Срок оценки: Through study completion, an average of 1 year]
  • Dual-task gait performance 3 [Срок оценки: Through study completion, an average of 1 year]
  • Dual-task cognitive performance 1 [Срок оценки: Through study completion, an average of 1 year]
  • Blood oxygenation level changes of the brain [Срок оценки: Through study completion, an average of 1 year]
  • Dual-task stride time [Срок оценки: Through study completion, an average of 1 year]
  • Dual-task cognitive performance 2 [Срок оценки: Through study completion, an average of 1 year]
  • Dual-task gait performance 4 [Срок оценки: Through study completion, an average of 1 year]

Критерии участия

Критерии включения

  • a diagnosis of stroke, stroke onset of more than 6 months,
  • aged 50 or more,
  • capable of following verbal and visual instructions,
  • having a Montreal Cognitive Assessment score ≥ 22,
  • able to walk for 10 meters with/without a mobility aid,
  • community-dwelling, unilateral stroke

Критерии исключения

  • neurological disorders, gait-precluding pain or comorbidity,
  • receiving any formal rehabilitation training,
  • contraindications to exercise (e.g., unstable angina),
  • contraindications to fNIRS, MRI, and tDCS (e.g., brain skin injury, pacemaker, metal implants in the brain),
  • history of seizure or epilepsy,
  • color blindness.
  • unable to walk with/without a mobility aid while responsing stimulus by the remote control

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Нет

Дизайн исследования

Распределение
Рандомизированное
Модель
Параллельные группы
Маскирование
Двойное слепое
Основная цель
Лечение

Центры проведения

Гонконг · 1 центр
  • The Hong Kong Polytechnic University — Гонконг

Идентификаторы

NCT: NCT06769672 · Marco PANG_tDCS

Первоисточники (государственные реестры)

Открыть это исследование на ClinicalTrials.gov ↗