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Идёт набор NCT06769386

Investigation of Muscle Oxygenation in Patients With Rheumatoid Arthritis

— Наблюдательное Rheumatoid Arthritis

Ориентир для пациента и семьи

Простыми словами

Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.

Что изучают
Это наблюдательное исследование: исследуемое лечение участникам по протоколу не назначают.
Кому может быть актуально
Состояния в реестре: Rheumatoid Arthritis. Базовые параметры: 18 лет — 65 лет · Все.
Что важно проверить
Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
Где проводится
Turkey (Türkiye)
Следующий шаг
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Официальное название

Investigation of Respiratory Muscle Strength, Respiratory Muscle Endurance and Muscle Oxygenation in Patients With Rheumatoid Arthritis

Обзор

The aim of this study is to investigate respiratory muscle strength, respiratory muscle endurance, muscle oxygenation, upper extremity and lower extremity exercise capacity in rheumatoid arthritis patients compared with healthy individuals.

Подробное описание

Rheumatoid arthritis (RA) is a chronic progressive autoimmune disease of unknown etiology with symmetric erosive synovitis and multisystem involvement. The disease causes significant long-term morbidity, reduced functional capacity, and increased mortality rates. Patients with rheumatoid arthritis avoid physical activity due to pain and fatigue. Despite the advances in pharmacological treatments in recent years, functional losses due to rheumatic diseases the resulting deterioration in quality of life, and loss of work continue. Physical inactivity is known to have detrimental effects on the cardiovascular and pulmonary systems by reducing muscle strength and aerobic capacity. The physiological reasons underlying skeletal muscle oxygenation that may cause muscle dysfunction in rheumatoid arthritis have not been investigated. In these patients, decreased arterial oxygen may reduce exercise capacity and cause muscle deoxygenation.

In rheumatoid arthritis patients, decreases in respiratory muscle strength, lung volumes, oxygen consumption, and six minute walk test distance cause cardiopulmonary deconditioning. Decreased exercise capacity increases the risk of cardiovascular disease and causes mortality in patients with RA.

This study aimed to, the effects of respiratory muscle strength, respiratory muscle endurance, upper and lower extremity muscle oxygenation, and upper and lower extremity exercise capacity in patients with stable disease activity.

Первичные конечные точки

  • Evaluation of respiratory muscle strength [Срок оценки: First day]
  • Evaluation of respiratory muscle endurance [Срок оценки: First day]
  • Evaluation of Deltoid and Quadriceps Femoris Muscle Oxygenation [Срок оценки: First and second day]
  • Evaluation of Deltoid and Quadriceps Femoris Muscle Total Hemoglobin Level [Срок оценки: First and second day]
Вторичные конечные точки (2)
  • Evaluation of submaximal exercise capacity [Срок оценки: First day and second day]
  • Evaluation of upper extremity capacity [Срок оценки: First day and second day]

Критерии участия

Rheumatoid Arthritis Group

Критерии включения

  • Patients diagnosed with rheumatoid arthritis,
  • The ages of 18-65 years,
  • Volunteer to participate in the study will be included in the study.

Критерии исключения

  • Serious cardiopulmonary, neurological, neuromuscular, orthopedic and other systemic diseases or other diseases affecting physical functions,
  • Participated in a planned exercise program in the last three months,
  • Cognitive impairment that will cause difficulty in understanding and following exercise test instructions,
  • Contraindications to exercise testing or exercise training according to the American Sports Medicine Association will not be included in the study.

Control Group

Критерии включения

  • The ages of 18-65 years,
  • Volunteer to participate in the study will be included in the study.

Критерии исключения

  • Diagnosed chronic or systemic disease,
  • Regular exercise (physical activity) 3 days a week, 150 minutes/week of moderate intensity
  • Smoking 10 packs x years or more,
  • Pneumonia or any acute infection,
  • Healthy individuals with any psychiatric disorder will not be included in the study.

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Да

Дизайн исследования

Модель наблюдения
Случай-контроль

Центры проведения

Turkey (Türkiye) · 1 центр
  • Kırşehir Ahi Evran University, Physical Therapy and Rehabilitation Center, Cardiopulmonary — Kırşehir

Публикации

  • Wickerson L, Mathur S, Brooks D, Bonetti LV, Singer LG, Granton J, Reid WD. Skeletal muscle oxygenation and regional blood volume during incremental limb loading in interstitial lung disease. ERJ Open Res. 2020 Jan 27;6(1):00083-2019. doi: 10.1183/23120541.00083-2019. eCollection 2020 Jan. PMID 32010722
  • Cimen B, Deviren SD, Yorgancloglu ZR. Pulmonary function tests, aerobic capacity, respiratory muscle strength and endurance of patients with rheumatoid arthritis. Clin Rheumatol. 2001;20(3):168-73. doi: 10.1007/s100670170058. PMID 11434466

Идентификаторы

NCT: NCT06769386 · AhiEvranU526

Первоисточники (государственные реестры)

Открыть это исследование на ClinicalTrials.gov ↗