Идёт набор NCT06761274

Study of Epigenetic and Inflammatory Markers of Accelerated Biological Ageing in the Follow up of Patients With Hodgkin's Lymphoma

Без фазы С лечением Hodgkin Lymphoma in Remission

Ориентир для пациента и семьи

Простыми словами

Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.

Что изучают: В протоколе указаны: peripheral blood sampling.
Кому может быть актуально: Состояния в реестре: Hodgkin Lymphoma in Remission. Базовые параметры: от 18 лет · Все.
Что важно проверить: Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
Где проводится: Италия
Следующий шаг: Сохраните исследование, покажите его лечащему врачу и уточните актуальный статус у исследовательского центра. Расходы, документы и поездка →

Не всё понятно в терминах? Прочитайте наш гид для пациентов →

Официальное название

Study of Epigenetic and Inflammatory Markers of Accelerated Biological Ageing in the Follow-up of Patients With Hodgkin's Lymphoma in Complete Remission for at Least 2 Years

Обзор

Study design: It is a monocentric and exploratory study, experimental on human tissues in vitro which involves the analysis of peripheral blood in patients with Hodgkin's lymphomas with the following characteristics: * in complete remission for at least two years after first-line therapy with stage IIb, III or IV at onset (Ann Arbor classification). * newly diagnosed (stage IIb, III or IV, Ann Arbor Classification).

Подробное описание

The study aims to evaluate patients with hodgkin lymphoma in complete remission for at least 2 years and newly diagnosed (stage II b, stage III or stage IV) as they are currently characterised by a long life expectancy during which there is an increased and early incidence of non-neoplastic systemic complications as well as, of course, manifestations of secondary malignancies.

Вмешательства

Другое peripheral blood sampling
It is a monocentric and exploratory study, experimental on human tissues in vitro and similar projects do not exist in the literature. This study involves the analysis of peripheral blood in patients with hodgkin lymphoma with the following characteristics: * in complete remission for at least two years after first-line therapy with stage II b, III or IV at onset (Ann Arbor classification). * newly diagnosed (stage II b, III or IV, Ann Arbor Classification).

Первичные конечные точки

evaluation of senescence markers (CD57, KLRG1,CD62L, CD45RA) [Срок оценки: through study completion, an average of 2 year]
DNA methylation (methylation rate) [Срок оценки: through study completion, an average of 2 year]

Вторичные конечные точки (2)

evaluation of senescence markers (CD57, KLRG1,CD62L, CD45RA) [Срок оценки: through study completion, an average of 2 year]
DNA methylation (methylation rate) [Срок оценки: through study completion, an average of 2 year]

Критерии участия

Критерии включения

hodgkin lymphoma stage II b, III or IV at onset in remission for at least two years after the first line of therapy for lymphoma
Newly diagnosed histologically confirmed stage II b, III or IV patients who require first-line therapy
Patients of both sexes aged ≥ 18 years at enrollment
Signature of informed consent