Association of Neutrophil- Lymphocyte Count Ratio and Microbial Infection in Hospitalized Patients
Ориентир для пациента и семьи
Простыми словами
Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.
- Что изучают
- Это наблюдательное исследование: исследуемое лечение участникам по протоколу не назначают.
- Кому может быть актуально
- Состояния в реестре: Microbial Infection. Базовые параметры: от 18 лет · Все.
- Что важно проверить
- Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
- Где проводится
- Список центров уточняется — проверьте первичный протокол.
- Следующий шаг
- Сохраните исследование, покажите его лечащему врачу и уточните актуальный статус у исследовательского центра. Расходы, документы и поездка →
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Обзор
Microbial infection is one of leading cause of morbidity and mortality in the world. Bacteremia that result from microbial infection has mortality rate as high as 30% . Systemic infections that result from microbial infection is a generalized disease that progresses rapidly and can lead to high mortality. This infection sets in from a progression of various pathogenic microorganisms that enter the bloodstream, reproduce and then release toxins and metabolites . Early diagnosis of microbial infection is essential for treatment. Culturing microorganisms is the most definitive way to confirm bacterial infections. Unfortunately, this gold standard is time consuming and may take from 24 to 48 hours and sometimes up to a week. A number of rapid initial indicators of microbial infection have been proposed, including C-reactive protein, neutrophil count, and white blood cell count. However, these criteria do not always reliably distinguish between severe bacterial, fungal, and viral infections . Therefore, the neutrophil-to-lymphocyte ratio (NLCR), a simple ratio between the number of neutrophils and lymphocytes measured in peripheral blood, has been proposed as a biomarker that combines two aspects of the immune system: the innate immune response, which is mainly driven by neutrophils, and adaptive immunity, supported by lymphocytes . This study aims to determine the diagnostic value of the neutrophil-to-lymphocyte ratio (NLCR) as an indicator of microbial infection, using complete blood count to determine the ratio in addition to culture and sensitivity according to the site of infection. the aim of this study is to Investigating the association between neutrophil-lymphocyte count and the presence of microbial infection in the hospitalized patients.
Подробное описание
Microbial infection is one of leading cause of morbidity and mortality in the world. Bacteremia that result from microbial infection has mortality rate as high as 30% . Systemic infections that result from microbial infection is a generalized disease that progresses rapidly and can lead to high mortality. This infection sets in from a progression of various pathogenic microorganisms that enter the bloodstream, reproduce and then release toxins and metabolites . Early diagnosis of microbial infection is essential for treatment. Culturing microorganisms is the most definitive way to confirm bacterial infections. Unfortunately, this gold standard is time consuming and may take from 24 to 48 hours and sometimes up to a week. A number of rapid initial indicators of microbial infection have been proposed, including C-reactive protein, neutrophil count, and white blood cell count. However, these criteria do not always reliably distinguish between severe bacterial, fungal, and viral infections . Therefore, the neutrophil-to-lymphocyte ratio (NLCR), a simple ratio between the number of neutrophils and lymphocytes measured in peripheral blood, has been proposed as a biomarker that combines two aspects of the immune system: the innate immune response, which is mainly driven by neutrophils, and adaptive immunity, supported by lymphocytes . This study aims to determine the diagnostic value of the neutrophil-to-lymphocyte ratio (NLCR) as an indicator of microbial infection, using complete blood count to determine the ratio in addition to culture and sensitivity according to the site of infection.
Первичные конечные точки
- neutrophil-lymphocyte count ratio [Срок оценки: baseline]
Критерии участия
Критерии включения
- age more than 18 years old
- both sex
- conformed diagnosis with micorbial infection
Критерии исключения
- Immunodeficiency patients
Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.
Здоровые добровольцы: Нет
Дизайн исследования
- Модель наблюдения
- Только случаи
Центры проведения
Список центров уточняется — проверьте первичный протокол.
Идентификаторы
NCT: NCT06759662 · N-L count ratio microbial inf