Downhill Walking in IPF

Официальное название

Effects of Downhill Walking in Pulmonary Rehabilitation for Patients With Idiopathic Pulmonary Fibrosis

Обзор

In this study; will examine the effects of downhill walking (eccentric exercise training) on exercise capacity, quality of life, and blood lactate levels in individuals with IPF. After the initial assessment, patients will be randomized into two groups: downhill walking PR group and Standard PR Group.

Подробное описание

Individuals diagnosed with idiopathic pulmonary fibrosis who come to the Pulmonary Rehabilitation Unit of Istanbul Süreyyapaşa Chest Diseases and Chest Surgery Education and Research Hospital will be included in this study. Those who meet the inclusion criteria will be randomized into two groups: Downhill Walking Pr Group (n=17) and Standard Pr Group (n=17). Patients will have exercise sessions twice a week for 8 weeks. Patients will be evaluated immediately before the rehabilitation program and the end of 8 weeks exercise programme. In our study, downhill walking training will differ from traditional walking training only in terms of treadmill training protocol. Traditional walking training involves walking on a motorized treadmill with a neutral incline, progressing with increases in speed, while downhill walking training will be performed at a constant -10% incline.

Вмешательства

• Другое Pulmonary Rehabilitation
  8 weeks, 2 sessions per week, Aerobic training will be provided as treadmill walking. It will be performed either downhill or on a flat treadmill, depending on the group. Warm-up and stretching exercises Resistance exercises will be performed with a load equivalent to 50% of 1 maximum repetition. 10 repetitions will be performed in sets, one set in each session. Based on the differences in the general condition of the patients, different workloads and modifications will be used when creating
• Другое Downhill Walking
  Treadmill exercise will be applied for 30 minutes in the target heart rate range of 60-80% intensity. The target heart rate method will be used to determine the exercise intensity. Blood pressure, heart rate and Borg Perceived Exertion Scale scores will be monitored during the exercises. Downhill walking training will continue with a constant -10% incline.
• Другое Treadmill Walking without incline
  Treadmill exercise will be applied for 30 minutes in the target heart rate range of 60-80% intensity. The target heart rate method will be used to determine the exercise intensity. Blood pressure, heart rate and Borg Perceived Exertion Scale scores will be monitored during the exercises. Traditional walking training will initially involve walking with a neutral incline.

Первичные конечные точки

• 6 Minutes Walking Distance (6MWD) [Срок оценки: Baseline and the end of the 8 weeks exercise program]
• Saint George Quality of life questionnaire [Срок оценки: Baseline and the end of the 8 weeks exercise program]

Вторичные конечные точки (10)

• Spirometric measurements (Forced vital capacity) [Срок оценки: Baseline and the end of the 8 weeks exercise program]
• Spirometric measurements (First second forced expiratory volume) [Срок оценки: Baseline and the end of the 8 weeks exercise program]
• Spirometric measurements (FEV1/FVC ratio) [Срок оценки: Baseline and the end of the 8 weeks exercise program]
• Peripheral muscle strength [Срок оценки: Baseline and the end of the 8 weeks exercise program]
• Hand grip strength [Срок оценки: Baseline and the end of the 8 weeks exercise program]
• Modified Medical Research Council Dyspnea Score [Срок оценки: Baseline and the end of the 8 weeks exercise program]
• Fatigue severity scale [Срок оценки: Baseline and the end of the 8 weeks exercise program]
• Hospital anxiety depression scale (HADS) [Срок оценки: Baseline and the end of the 8 weeks exercise program]
• Determination of blood lactate level [Срок оценки: Baseline and the end of the 8 weeks exercise program]
• Carbon monoxide diffusion capacity [Срок оценки: Baseline and the end of the 8 weeks exercise program]

Критерии участия

Критерии включения

• Having a diagnosis of IPF according to the clinical diagnostic criteria of the American Thoracic Society and/or the European Respiratory Society (ATS-ERS).
• Being between the ages of 18 and 75.
• Being able to walk on a treadmill.
• Having the ability to cooperate.
• No change in current medication in the last month.
• Not participating in a structured activity program for at least six months.
• Accepting the purpose and method of this study voluntarily and give informed consent for the study.

Критерии исключения

• Presence of physical or mental impairment that prevents informed consent or compliance with the protocol.
• Inability to attend more than 20% of pulmonary rehabilitation sessions.
• Presence of major cardiovascular disease (coronary artery disease, uncontrolled hypertension, arrhythmias, or heart failure).
• Presence of existing orthopedic and neuromuscular exercise limitations.
• Acute exacerbation

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Нет

Дизайн исследования

Распределение

Рандомизированное

Модель

Параллельные группы

Маскирование

Простое слепое

Основная цель

Лечение

Центры проведения

Turkey (Türkiye) · 1 центр

• Saglik Bilimleri Universitesi — Istanbul

Идентификаторы

NCT: NCT06756230 · Eccentric_IPF

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

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