TCM Tongue Diagnosis and Syndrome Differentiation in Myasthenia Gravis Compared to Healthy Controls

Официальное название

Application of Artificial Intelligence for Precision Medicine in TCM Tongue Diagnosis and Syndrome Differentiation in Myasthenia Gravis Compared to Healthy Controls

Обзор

Myasthenia gravis primarily results from neuromuscular junction dysfunction and damage, leading to chronic muscle weakness. While combined traditional and Western medicine treatments are now common, TCM tongue diagnosis remains a simple and practical clinical method. However, results can vary among different practitioners. Therefore, you are interested in using scientific methods to compare TCM tongue diagnosis images between patients with myasthenia gravis and healthy individuals to aid in diagnosis.

Подробное описание

In Taiwan, the prevalence of severe myasthenia gravis is approximately 14 per 100,000 people, with an incidence rate of about 2 per 100,000 people.

Currently, combined traditional and Western medicine treatments are very popular. In Traditional Chinese Medicine (TCM), tongue diagnosis is a simple and practical clinical method, focusing on aspects such as the tongue body, coating, color, and sublingual veins. Clinical evaluation often relies on the experience and knowledge of TCM practitioners, which can be influenced by subjective factors like diagnostic skills. As a result, findings may vary depending on the observer.

To improve diagnostic accuracy, using scientific methods to support TCM tongue diagnosis can provide more precise information for practitioners and enhance the clinical application value of tongue diagnosis in TCM.

Вмешательства

• Устройство Heart Rate Variability,HRV - ANSWatch
  Please have the participant lie down and rest for 10 minutes, and remove any metallic items from their body. Next, put on the wrist-worn monitor, and avoid moving during the monitoring process. The device will emit a sound when the monitoring session is complete.
• Устройство Traditional Chinese Medicine Tongue Imaging
  Use a camera to capture images of the tongue, and then have a Traditional Chinese Medicine (TCM) practitioner perform the diagnosis based on these images.

Первичные конечные точки

• What are the differences in tongue diagnosis in traditional Chinese medicine between the disease group and the healthy population? [Срок оценки: 2025/01/18 (4th week)]

Вторичные конечные точки (1)

• Observe the differences in physical constitution and tongue diagnosis between patients with myasthenia and healthy people. [Срок оценки: 2025/01/18 (4th week)]

Критерии участия

Критерии включения

• Diagnosed with myasthenia gravis by a physician.
• Able to understand and communicate in Mandarin and Taiwanese.
• Cognitively alert and without a diagnosis of psychiatric disorders.
• Willing to undergo tongue imaging and instrument measurements.

Критерии исключения

• Patients with severe organ diseases.
• Hearing loss patients who are unable to complete the questionnaire.
• Patients with aphasia who are unable to complete the questionnaire.
• Have eaten food or drinks that can easily contaminate tongue coating within 2 hours.

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Да

Дизайн исследования

Распределение

Нерандомизированное

Модель

Параллельные группы

Маскирование

Открытое

Основная цель

Организация здравоохранения

Центры проведения

Тайвань · 1 центр

• Yi Ting Yeh — New Taipei City

Идентификаторы

NCT: NCT06754020 · 20221019R

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

Открыть это исследование на ClinicalTrials.gov ↗