Investigating Novel Strategies in Pediatric Immune Responses and Microbiome Environment: Comprehensive Lung Disease Investigation in Children.
Ориентир для пациента и семьи
Простыми словами
Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.
- Что изучают
- В протоколе указаны: No intervention.
- Кому может быть актуально
- Состояния в реестре: Lung Diseases. Базовые параметры: 0 лет — 17 лет · Все.
- Что важно проверить
- Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
- Где проводится
- Дания
- Следующий шаг
- Сохраните исследование, покажите его лечащему врачу и уточните актуальный статус у исследовательского центра. Расходы, документы и поездка →
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Официальное название
INSPIRE CHILD: Investigating Novel Strategies in Pediatric Immune Responses and Microbiome Environment: Comprehensive Lung Disease Investigation in Children
Обзор
The INSPIRE CHILD-study is a clinical research project focused on understanding lung diseases in children. The study aims to explore how the presence of certain bacteria, immune responses, and inflammatory markers in the lungs are connected to different lung diseases in pediatric patients. Background: Lung diseases in children can have long-lasting effects on their health, not only during childhood but also as they grow into adults. However, the specific causes and mechanisms behind these diseases are not yet fully understood. The INSPIRE CHILD-study is designed to investigate whether children with various lung conditions have distinct differences in the types of bacteria, immune system activity, and inflammation in their lungs. Hypothesis: Different lung diseases in children are hypothesized to be associated with unique patterns of bacteria, immune responses, and inflammation in the lungs By studying these patterns, the investigators hope to gain new insights that could lead to better diagnostic tools and more personalized treatments for children suffering from lung diseases. Children already scheduled to undergo bronchoscopy are included in the study. A small sample of fluid from the lungs is collected, and the sample is analyzed for bacteria, immune markers, and signs of inflammation. This research could pave the way for improved care and treatment for young patients with lung conditions.
Вмешательства
- Другое No intervention
No intervention
Первичные конечные точки
- Cytokines [Срок оценки: Day 0 (Subsequent to study inclusion)]
- Immunophenotype [Срок оценки: Day 0 (Subsequent to study inclusion)]
- Lung microbiome [Срок оценки: Day 0 (Subsequent to study inclusion)]
Вторичные конечные точки (3)
- Concentration range for selected interleukins in BAL-fluid [Срок оценки: Day 0 (Subsequent to study inclusion)]
- Lung disease association [Срок оценки: Through study completion, an average of 2 year]
- Clinical symptoms [Срок оценки: 2 weeks prior to enrollment]
Критерии участия
Критерии включения
- Age ranging from new-born to 17 years of age.
- Diagnosed with or being assessed for a lung disease.
- Possible to sample at least 2 ml of BAL-fluid besides the scheduled amount during the bronchoscopy.
Критерии исключения
- Age older than 17 years.
- Not undergoing diagnosis at Childrens Center for Pulmonary and Allergic diseases.
- Failure to meet the requirement of being able to sample an additional 2 ml of BAL-fluid.
Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.
Здоровые добровольцы: Нет
Дизайн исследования
- Модель наблюдения
- Когортное
Центры проведения
Дания · 1 центр
- Childrens Center for Pulmonary and Allergic diseases, Aarhus University Hospital — Aarhus N
Идентификаторы
NCT: NCT06746077 · VEK j.nr. 1-10-72-8-24