Study of HRS-2189 Combined HRS-5041 in Prostate Cancer

Официальное название

A Phase II Study of HRS-2189 Combined HRS-5041 in Metastatic Prostate Cancer

Обзор

Our study is aimed to evaluate the efficacy and safety of HRS-2189 combined with HRS-5041 in metastatic prostate cancer.

Вмешательства

• Препарат HRS-2189
  HRS-2189
• Препарат HRS-5041
  HRS-5041

Первичные конечные точки

• PSA50 [Срок оценки: up to 2 years]

Вторичные конечные точки (9)

• PSA30 [Срок оценки: up to 2 years]
• Time to PSA progression [Срок оценки: up to 2 years]
• ORR by investigator [Срок оценки: up to 2 years]
• DCR by investigator [Срок оценки: up to 2 years]
• DoR [Срок оценки: up to 2 years]
• rPFS [Срок оценки: up to 2 years]
• Time to next skeletal-related event [Срок оценки: up to 2 years]
• OS [Срок оценки: up to 2 years]
• Percentage of participants who experience an adverse event [Safety and Tolerability] [Срок оценки: From the time of informed consent provided to 30 days after the last dose of study therapy]

Критерии участия

Критерии включения

• 18 years to 80 years old (including boundary values), male subjects;
• ECOG PS Score: 0\~1;
• Histologically or cytologically confirmed prostate adenocarcinoma, and no prior diagnosed as neuroendocrine carcinoma or small cell carcinoma;
• Disease progression when enrolled in the study;
• Confirmed metastatic disease by CT/MRI/99mTc radioactive bone scan;
• Subjects must have a life expectancy ≥ 3 months;
• Adequate organ function and marrow function (no corrective treatment within 14 days before first dose);
• Male subjects who have partner of childbearing potential should agree to take action of contraception and avoid to donate sperm;
• Willing and able to provide written informed consent and comply with the requirements and restrictions in the protocol.

Критерии исключения

• Known existence of CNS metastasis or meningeal metastasis, or known history of primary CNS tumor;
• Severe bone injury caused by bone metastasis identified by investigators, including uncontrolled severe bone pain, pathological bone fracture at the important part and spinal cord compression having occurred for the last 6 months or expected to occur in the near future;
• Existence of third space fluid that is not well controlled by effective methods, e.g. drainage;
• Has received antitumor surgery, radiotherapy, chemotherapy, targeted therapy, immunological therapy or attenuated live vaccine within 4 weeks before first dose of study therapy (6-week washout period for bicalutamide);
• Has been enrolled in other clinical trials within 4 weeks before first dose of study therapy;
• Use of other antitumor treatment during the study;
• Damage caused by any prior anti-tumor treatment has not recovered to ≤ grade 1 or criteria specified by this study (per NCI-CTCAE 5.0; except alopecia or other tolerable adverse events identified by investigators);
• Uncontrolled hypertension, or prior hypertensive crisis or history of hypertension;
• Existence of arterial/venous thrombotic event within 6 months before first dose, such as cerebrovascular accidents (including transient ischemic attack, cerebral haemorrhage and cerebral infarction), deep venous thrombosis and pulmonary embolism;
• Existence of one of multiple factors that affect oral medication (such as inability to swallow, chronic diarrhea and bowel obstruction), or active gastrointestinal disease or other diseases which may obviously affect distribution of drug absorption, metabolism or excretion;
• Has active hepatitis B (HBsAg-positive and HBV DNA≥500 IU/mL), hepatitis C (positive for HCV antibody and HCV RNA above ULN) and hepatic cirrhosis;
• Has an active infection requiring antibiotics, antiviral or antifungal treatment, or pyrexia >38.5℃ of unknown origin during the screening period before first dose of study therapy (patients with pyrexia due to cancer could be enrolled determined by investigator);
• Subjects with innate or acquired immunodeficiency (such as HIV infection); Known history of allogeneic organ transplantation or hematopoietic stem cell transplantation;
• Other malignancy within prior 3 years before first dose of study therapy, except curatively treated cancer, including radical therapy-treated skin basal cell carcinoma or skin squamous cell carcinoma, papillary thyroid carcinoma, or any type of in situ carcinoma with complete excision, such as in situ cancer of the cervix, ductal carcinoma in situ of breast;
• Hypersensitivity to study therapy or any of its excipients;
• Uncontrolled cardiovascular clinical symptom or disease within 6 months before first dose of study therapy;
• Other conditions that might influence the study and analysis of results in the opinion of the investigator.

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Нет

Дизайн исследования

Распределение

Не применимо

Модель

Одна группа

Маскирование

Открытое

Основная цель

Лечение

Центры проведения

Китай · 1 центр

• Fudan Cancer Hospital — Шанхай

Идентификаторы

NCT: NCT06738745 · CRPC-MUL-IIT-HRS2189-HRS5041

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

Открыть это исследование на ClinicalTrials.gov ↗