Study of Pneumococcal Carriage in RSV Bronchiolitis in Infants Aged 6 to 18 Months
Ориентир для пациента и семьи
Простыми словами
Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.
- Что изучают
- В протоколе указаны: Swab collection.
- Кому может быть актуально
- Состояния в реестре: Bronchiolitis. Базовые параметры: 6 мес. — 18 мес. · Все.
- Что важно проверить
- Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
- Где проводится
- Франция
- Следующий шаг
- Сохраните исследование, покажите его лечащему врачу и уточните актуальный статус у исследовательского центра. Расходы, документы и поездка →
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Обзор
The relationship between RSV (human respiratory syncytial virus) infections and invasive infections or pneumonia caused by Streptococcus pneumoniae has been observed epidemiologically for several years. Few fundamental data exist to support the epidemiological relationship. This study will investigate the proportion of pneumococcal carriage in RSV-infected infants and noninfected infants (proportion, serotype profile).
Подробное описание
The relationship between RSV (human respiratory syncytial virus) infections and Streptococcus pneumoniae pneumonia has been suggested for many years based on a similar seasonal pattern and cohort studies, but it could not be confirmed due to the circulation of several viruses concurrently. The post-COVID-19 period was marked by a temporal association between RSV infections and invasive pneumococcal disease (and pneumonia) in children under five, highlighting the potential role of RSV in the dynamics of pneumococcal disease in infants.
Furthermore, the carriage rate of S. pneumoniae in infants under 2 years of age in healthy populations is described as around 25%. In the case of RSV infection, this rate rises to 50%. Some data from animal models have shown that RSV infection increases S. pneumoniae transmission within a group of individuals, partly explaining this difference. However, data remain limited, particularly in human samples, and further research is needed to better understand the role of the RSV-pneumococcal relationship in the occurrence of severe RSV infections (pneumonia) and invasive pneumococcal infections. This study will examine pneumococcal carriage in bronchiolitis in infants aged 6-18 months, through nasopharyngeal swabs from infants with bronchiolitis and healthy infants. Pneumococcal carriage rates and serotype profiles will be investigated.
Вмешательства
- Другое Swab collection
Nasopharyngeal swab
Первичные конечные точки
- nasopharyngeal carriage rate of Streptococcus pneumoniae (Sp) [Срок оценки: Inclusion]
Вторичные конечные точки (5)
- serotype profile [Срок оценки: Inclusion]
- serotype profile [Срок оценки: Inclusion]
- proportion of 13-valent and 23-valent vaccine serotypes [Срок оценки: Inclusion]
- proportion of non-vaccine serotypes [Срок оценки: Inclusion]
- Serotype profile distribution [Срок оценки: Inclusion]
Критерии участия
Критерии включения
- Infants aged 6 months to 18 months inclusive
- With bronchiolitis during RSV epidemic season (bronchiolitis group) or without evidence of RSV viral infection (healthy group)
- No chronic illness
- No history of bronchiolitis
- Signed consent from parents or legal guardians
- Patient affiliated to a social security scheme
Критерии исключения
- Chronic respiratory illness
- Medical history of bronchiolitis or newborn asthma
- Treatment with immunosuppressants
- Patient on AME
Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.
Здоровые добровольцы: Да
Дизайн исследования
- Модель наблюдения
- Случай-контроль
Центры проведения
Франция · 1 центр
- Hôpital Antoine Béclère — Clamart
Идентификаторы
NCT: NCT06722716 · APHP240862 · 2024-A01592-45