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Набор скоро начнётся NCT06703138

Role of Diffusion MRI in Differentiation of Various Bone Marrow Lesions

— Наблюдательное Diffusion MRI Bone Marrow Disease

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Простыми словами

Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.

Что изучают
Это наблюдательное исследование: исследуемое лечение участникам по протоколу не назначают.
Кому может быть актуально
Состояния в реестре: Diffusion MRI, Bone Marrow Disease. Базовые параметры: 20 лет — 60 лет · Все.
Что важно проверить
Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
Где проводится
Список центров уточняется — проверьте первичный протокол.
Следующий шаг
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Официальное название

Role of MRI Diffusion in Differentiation Between Various Vertebral Bone Marrow Pathological Lesions. .

Обзор

Bone marrow lesions are common, and imaging findings are associated with various aetiologies, as compared to conventional radiography and computed tomography (CT), MRI is a better non-invasive imaging modality to evaluate vertebral bone marrow, due to better soft-tissue contrast, so the aim of our study is the use of MRI diffusion in differentiating various vertebral bone marrow pathological lesions.

Подробное описание

Bone marrow lesions are common, and imaging findings are associated with various aetiologies, such as degenerative, infectious, traumatic, malignant, metabolic, and haematopoietic .

As compared to conventional radiography and computed tomography (CT), MRI is a better non-invasive imaging modality to evaluate vertebral bone marrow, due to better soft-tissue contrast as well as being non-ionising in nature .

Although conventional MRI is essential for anatomical visualization and lesion detection in bone marrow pathologies ,but it often insufficient in distinguishing different vertebral bone marrow lesions, due to overlapping imaging features and often due to coexistence of bone marrow oedema that can be caused by fractures, infection, and bone marrow hyperplasia, thus reducing the specificity of conventional sequences .

MRI diffusion provides complementary information about tissue microstructure and cellular .it exploits the translational mobility of water molecules to obtain information on the microscopic behaviour of the tissues.

On the other hand, apparent diffusion coefficient (ADC) values provide quantitative measure of Brownian movement with low ADC values implying restricted diffusion and high values being a measure of free diffusion.

Therefore, DWI provides both qualitative and quantitative functional information concerning the microscopic movements of water at the cellular level. The benefits of DWI comprise a small scanning period that allows it to be easily included in the routine imaging protocols .

For example, In healthy bone marrow, water diffusion is relatively unrestricted due to its cellularity and vascularity, while pathologies such as metastatic disease or myelofibrosis typically exhibit restricted diffusion.

Diffusion MRI can also distinguish bone marrow edema like acute injury or inflammation, from infiltrative diseases such as multiple myeloma. Edema typically shows higher ADC values due to the increased water content, whereas infiltrative diseases reduce diffusion, resulting in lower ADC values.

These examples illustrate how MRI diffusion can differentiate various vertebral bone marrow pathological lesions.

Первичные конечные точки

  • Evaluation of the efficacy of MRI diffusion in differentiation between Various Vertebral bone marrow pathological lesions. . [Срок оценки: Baseline]

Критерии участия

Критерии включения

  • All adult patients with vertebral lesions Clinically suspected or diagnosed by other modalities as X-ray or CT were included in the study.

Критерии исключения

  • Patients with metallic prosthesis which are not MRI compatible .
  • patients with previous Vertebral surgery.
  • patients with Vertebral Congenital anomalies
  • Patients refused the examination.
  • Patients who suffer from claustrophobia

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Дизайн исследования

Модель наблюдения
Другое

Центры проведения

Список центров уточняется — проверьте первичный протокол.

Публикации

  • Leake RL, Mills MK, Hanrahan CJ. Spinal Marrow Imaging: Clues to Disease. Radiol Clin North Am. 2019 Mar;57(2):359-375. doi: 10.1016/j.rcl.2018.09.008. Epub 2018 Nov 17. PMID 30709475
  • Lin S, Ouyang T, Kanekar S. Imaging of Bone Marrow. Hematol Oncol Clin North Am. 2016 Aug;30(4):945-71. doi: 10.1016/j.hoc.2016.03.012. PMID 27444005
  • Dietrich O, Geith T, Reiser MF, Baur-Melnyk A. Diffusion imaging of the vertebral bone marrow. NMR Biomed. 2017 Mar;30(3). doi: 10.1002/nbm.3333. Epub 2015 Jun 26. PMID 26114411
  • Karampinos DC, Ruschke S, Dieckmeyer M, Diefenbach M, Franz D, Gersing AS, Krug R, Baum T. Quantitative MRI and spectroscopy of bone marrow. J Magn Reson Imaging. 2018 Feb;47(2):332-353. doi: 10.1002/jmri.25769. Epub 2017 Jun 1. PMID 28570033
  • Padhani AR, Koh DM. Diffusion MR imaging for monitoring of treatment response. Magn Reson Imaging Clin N Am. 2011 Feb;19(1):181-209. doi: 10.1016/j.mric.2010.10.004. PMID 21129641

Идентификаторы

NCT: NCT06703138 · MRI in bone marrow lesions

Первоисточники (государственные реестры)

Открыть это исследование на ClinicalTrials.gov ↗