Neuroscience of Psychotherapy for Depression

Официальное название

Interbrain Synchronization of the Therapist-Client Dyad in Psychotherapy: Pilot EEG Study in Students With Mild-Moderate Depression Symptoms

Обзор

The goal of this study is to learn the extent to which client-therapist brain activity may synchronize during a psychosocial intervention for depression symptoms. The study will compare behavioral activation, a client-centered type of cognitive-behavioral therapy, to psychoeducation which delivers information on strategies to recover from depression symptoms. Participants will answer questions about their mental and physical health, attend one psychosocial intervention session receiving either Behavioral Activation or Psychoeducation with simultaneous brain activity measurement and complete follow up surveys two weeks and one month following the intervention.

Подробное описание

This is a pilot study to investigate the neuroscience of a single-session psychosocial intervention for depression symptoms. Brain activity is measured with EEG in both research participant and therapist. Participants will fill in questionnaires about their depression symptoms and experience during the psychosocial intervention.

Вмешательства

• Поведенческое Psychoeducation
  For the psychoeducation session, the focus is for the therapist to engage with the client regarding mental health broadly without a targeted effort to reinforce therapeutic alliance or to offer individualized guidance or techniques. The session will provide educational information on depression, depression symptoms and known causes, and strategies to reduce depression symptoms. The content will be delivered in a fashion to avoid individualization and psychotherapeutic exchange. The elements will
• Поведенческое Behavioral Activation
  Behavioral Activation (BA) is a psychotherapy treatment modality used for depression and focuses on replacing maladaptive coping mechanism that reinforce depressive symptoms with adaptive coping mechanisms to increase exposure to positive reinforcement. The treatment will consist of the following elements: Introduction to establish concept of positive reinforcement and build rapport, identification of client-centered values, individualized values-based activity planning and scheduling, and devel

Первичные конечные точки

• Inter-brain phase synchronization in Alpha frequency band via Phase Locking Value [Срок оценки: During the interventional session, approximately 60 minutes]
• Inter-brain phase synchronization in Theta frequency band via Phase Locking Value [Срок оценки: During the interventional session, approximately 60 minutes]

Вторичные конечные точки (4)

• Directed inter-brain connectivity in theta frequency band via Granger Causality [Срок оценки: During the intervention session, approximately 60 minutes]
• Directed inter-brain connectivity in the Alpha frequency band via Granger Causality [Срок оценки: During the intervention session, approximately 60 minutes]
• Correlation between Inter-brain Phase Synchronization in Alpha frequency band via phase locking value and change in depression symptoms via Beck Depression Inventory II (BDI) total score [Срок оценки: Baseline Up to 4 weeks post-intervention session]
• Correlation between Inter-brain Phase Synchronization in Theta frequency band via phase locking value and change in depression symptoms via Beck Depression Inventory II total score [Срок оценки: Baseline Up to 4 weeks post-intervention session]

Критерии участия

Inclusion Criteria for participants/clients:

• Between ages 18 and 30
• Full-time student status (undergraduate, graduate, and professional)
• Experience mild to moderate depressive symptoms as determined by the Beck Depression Inventory (score: 14-28)
• Capacity to understand study procedures (informed consent)
• Ability to speak and understand English
• Willingness to comply with study procedures

Inclusion Criteria for therapists:

• Ages 18 or older
• Qualification to administer therapy (decided by the Principal Investigator)
• Capacity to understand the study procedures (informed consent)
• Speak and understand English
• Willingness to comply with study procedures

Exclusion Criteria for participants/clients:

• Active, Current Suicidal ideation as determined by the Columbia-Suicide Severity Rating Scale (C-SSRS) in the past month
• Past suicidal attempt (lifetime)
• Recently initiated psychotherapy (past month)
• Elevated psychosis risk based on self-report prodromal questionnaire - brief version (PQ-B) or self-reported diagnosis of psychotic disorder by mental health provider
• Positive screen for autism spectrum disorder based on the self-report autism quotient (AQ-10) or self-reported diagnosis of autism spectrum disorder by mental health provider,
• Daily intake of benzodiazepine of >20 mg diazepam milligram equivalent
• Inability to give informed, voluntary, written consent to participate
• Inability to effectively communicate in English as determined by interaction with study personnel
• Anything else that in the assessment of the study team is not conducive to the successful completion of the study requirements.

There are no exclusion criteria for therapists

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Нет

Дизайн исследования

Распределение

Рандомизированное

Модель

Параллельные группы

Маскирование

Простое слепое

Основная цель

Лечение

Центры проведения

США · 1 центр

• Carolina Center for Neurostimulation — Chapel Hill

Публикации

• Kazdin AE. Understanding how and why psychotherapy leads to change. Psychother Res. 2009 Jul;19(4-5):418-28. doi: 10.1080/10503300802448899. PMID 19034715
• Wampold BE. How important are the common factors in psychotherapy? An update. World Psychiatry. 2015 Oct;14(3):270-7. doi: 10.1002/wps.20238. PMID 26407772
• Hougaard E. The therapeutic alliance--a conceptual analysis. Scand J Psychol. 1994 Mar;35(1):67-85. doi: 10.1111/j.1467-9450.1994.tb00934.x. PMID 8191262
• Safran JD, Muran JC. Resolving therapeutic alliance ruptures: diversity and integration. J Clin Psychol. 2000 Feb;56(2):233-43. doi: 10.1002/(sici)1097-4679(200002)56:23.0.co;2-3. PMID 10718606
• Dumas G, Nadel J, Soussignan R, Martinerie J, Garnero L. Inter-brain synchronization during social interaction. PLoS One. 2010 Aug 17;5(8):e12166. doi: 10.1371/journal.pone.0012166. PMID 20808907

Идентификаторы

NCT: NCT06696001 · 22-1422

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

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