Neuropsychological Profiles and Musical Engagement in Parkinson's and Alzheimer's Disease

Официальное название

Observational Pilot Study of Neuropsychological Profiles and Musical Engagement in Parkinson's and Alzheimer's Disease. What Are the Effects of Mnestic or Hedonic Impairment on Emotion, Reminiscence and Musical Enjoyment

Обзор

The goal of this Multicenter observational pilot study is to Compare the specifics of musical engagement (behaviors related to music in everyday life) in subjects aged over 60 with Alzheimer s disease, Parkinson s disease and control subjects. The main questions it aims to answer are: 1. The description of different profiles of musical engagement in early-stage AD, in PD and in healthy elderly subjects. 2. The extent of executive, mnestic and hedonic dysfunctions will impact differently on emotional engagement, autobiographical evocation and sensitivity to musical reward, and will therefore enable distinct profiles to be drawn up. Participants will have an intervention consisting of an interview with a neuropsychologist lasting approximately 2 hours, including : * A semi-structured interview to check the participants eligibility and gather demographic data. * Neuropsychological tests and questionnaires will then be administered. * A relative of the study participant will help complete questionnaires.

Подробное описание

Music therapy appears to be highly relevant as a Non-Medication Intervention in Alzheimer s (AD) and Parkinson s disease (PD). It is said to reduce depressive symptoms following music therapy sessions in dementia . With regard to Parkinson s disease, music therapy brings benefits in terms of motor skills, communication, breathing and emotional aspects. Reviews point to the need to differentiate beneficial effects according to different pathologies.

To date, no study has investigated the evolution of sensitivity to musical reward in AD. Furthermore, no study has discriminated the evolution of musical engagement in several neurodegenerative pathologies.

Вмешательства

• Поведенческое neuropsychologist interview
  It will take place either at the hospital or at the participant's home. This interview will consist of : * socio-demographic data collection * neuropsychological tests: * MMSE test (Mini Mental State Examination) cognitive function * RL-RI-16 test (16-item free recall/indexed recall test) * BECS test (Semantic knowledge assessment battery ) * WCST test (Wisconsin Card Sorting Test ) * Musical Cognition Test * Help from the participant's relative to answer certain questions, in par
• Поведенческое questionnaire
  The participant answers questionnaires: * Questionnaire MusEQ-24 self reported (Music Engagement Questionnaire) * Questionnaire BMRQ (Barcelona Reward Music Questionnaire) * Questionnaire SHAPS (Snaith-Hamilton Pleasure Scale) * Questionnaire LARS (Lille's Apathy Rating Scale) * Questionnaire PHQ-9 (Patient Health Questionnaire 9 items)

Первичные конечные точки

• Comparison of the specificities of musical engagement (i.e., music-related behaviors in daily life) in Alzheimer's disease, Parkinson's disease, and among a population of healthy old adults. [Срок оценки: Baseline]

Вторичные конечные точки (12)

• The comparison of self- and hetero-questionnaires will be carried out within each group for each MUseQ24 dimension [Срок оценки: Baseline]
• Comparison of global cognition between Alzheimer's, Parkinson's and healthy elderly groups [Срок оценки: Baseline]
• Comparison of Executive Function between Alzheimer's, Parkinson's and healthy elderly groups [Срок оценки: Baseline]
• Comparison of Episodic Memory Function between Alzheimer's, Parkinson's and healthy elderly groups [Срок оценки: Baseline]
• Comparison of Semantic Memory Function between Alzheimer's, Parkinson's and healthy elderly groups [Срок оценки: Baseline]
• Comparison of Musical Cognition between Alzheimer's, Parkinson's and healthy elderly groups [Срок оценки: Baseline]
• Comparison of Semantic Musical Memory between Alzheimer's, Parkinson's and healthy elderly groups [Срок оценки: Baseline]
• Comparison of Sensitivity to musical reward between Alzheimer's, Parkinson's and healthy elderly groups [Срок оценки: Baseline]
• Comparison of Self-assessed musical engagement between Alzheimer's, Parkinson's and healthy elderly groups [Срок оценки: Baseline]
• Comparison of Memory recall during music listening reward between Alzheimer's, Parkinson's and healthy elderly groups [Срок оценки: Baseline]
• Comparison of emotional experience during music listening during music listening reward between Alzheimer's, Parkinson's and healthy elderly groups [Срок оценки: Baseline]
• Comparison of Hedonic function reward between Alzheimer's, Parkinson's and healthy elderly groups [Срок оценки: Baseline]

Критерии участия

Критерии включения

General inclusion criteria:

• 60 years and older
• French-speaking and volunteering for the study
• Living at home with a relative

Alzheimer's disease inclusion criteria:

• Biological diagnosis of probable Alzheimer's disease according to NINCDS-ADRDA criteria (McKhann et al., 1984)
• MMSE greater than or equal to 20

Inclusion criteria Parkinson's disease :

• Diagnosis of Idiopathic Parkinson's disease
• MMSE greater than or equal to 20

Критерии исключения

• No known neurological pathologies (epilepsy and other non-degenerative CNS diseases) or psychiatric disorders (chronic psychosis and psychotic episodes)
• Autistic disorders
• History of stroke or head trauma
• Unstable medical condition (cancer)
• Subject unable to read and/or write
• Hearing impairment without hearing aids
• Refusal of consent after information
• Persons unable to give consent, research carried out in emergency situations, etc.)
• Non-affiliation with a social security scheme
• Person deprived of liberty (by judicial or administrative decision, or forced hospitalization)
• Person under legal protection (guardianship, curatorship, legal protection)
• Person participating in another research project with an exclusion period still in progress

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Да

Дизайн исследования

Распределение

Нерандомизированное

Модель

Параллельные группы

Маскирование

Открытое

Основная цель

Фундаментальное исследование

Центры проведения

Франция · 3 центра

• Montpellier Seniors' Association — Montpellier
• CHU de Montpellier - CEPMo — Montpellier
• CHU de Montpellier - CMRR — Montpellier

Публикации

• Bian X, Wang Y, Zhao X, Zhang Z, Ding C. Does music therapy affect the global cognitive function of patients with dementia? A meta-analysis. NeuroRehabilitation. 2021;48(4):553-562. doi: 10.3233/NRE-210018. PMID 33967069
• Zhang Y, Cai J, An L, Hui F, Ren T, Ma H, Zhao Q. Does music therapy enhance behavioral and cognitive function in elderly dementia patients? A systematic review and meta-analysis. Ageing Res Rev. 2017 May;35:1-11. doi: 10.1016/j.arr.2016.12.003. Epub 2016 Dec 23. PMID 28025173
• van der Steen JT, van Soest-Poortvliet MC, van der Wouden JC, Bruinsma MS, Scholten RJ, Vink AC. Music-based therapeutic interventions for people with dementia. Cochrane Database Syst Rev. 2017 May 2;5(5):CD003477. doi: 10.1002/14651858.CD003477.pub3. PMID 28462986
• Platel H, Eustache ML, Coppalle R, Viard A, Eustache F, Groussard M, Desgranges B. Boosting Autobiographical Memory and the Sense of Identity of Alzheimer Patients Through Repeated Reminiscence Workshops? Front Psychol. 2021 Feb 15;12:636028. doi: 10.3389/fpsyg.2021.636028. eCollection 2021. PMID 33679562
• Morris IB, Vasudevan E, Schedel M, Weymouth D, Loomis J, Pinkhasov T, Muratori LM. Music to One's Ears: Familiarity and Music Engagement in People With Parkinson's Disease. Front Neurosci. 2019 Jun 25;13:661. doi: 10.3389/fnins.2019.00661. eCollection 2019. PMID 31293379
• Machado Sotomayor MJ, Arufe-Giraldez V, Ruiz-Rico G, Navarro-Paton R. Music Therapy and Parkinson's Disease: A Systematic Review from 2015-2020. Int J Environ Res Public Health. 2021 Nov 4;18(21):11618. doi: 10.3390/ijerph182111618. PMID 34770129
• Loas G, Duru C, Godefroy O, Krystkowiak P. Hedonic deficits in Parkinson's disease: is consummatory anhedonia specific? Front Neurol. 2014 Mar 10;5:24. doi: 10.3389/fneur.2014.00024. eCollection 2014. PMID 24653714
• Groussard M, Chan TG, Coppalle R, Platel H. Preservation of Musical Memory Throughout the Progression of Alzheimer's Disease? Toward a Reconciliation of Theoretical, Clinical, and Neuroimaging Evidence. J Alzheimers Dis. 2019;68(3):857-883. doi: 10.3233/JAD-180474. PMID 30883343

Идентификаторы

NCT: NCT06688968 · RECHMPL23_0427

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

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