Идёт набор NCT06679101

A Study of Belantamab Mafodotin Administered in Combination With Lenalidomide and Dexamethasone (BRd) Versus Daratumumab, Lenalidomide, and Dexamethasone (DRd) in Participants With Newly Diagnosed Multiple Myeloma (NDMM) Who Are Ineligible for Autologous Stem Cell Transplantation (TI-NDMM)

Фаза III С лечением Multiple Myeloma Newly Diagnosed Multiple Myeloma

Ориентир для пациента и семьи

Простыми словами

Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.

Что изучают: В протоколе указаны: Belantamab mafodotin, Lenalidomide, Dexamethasone, Daratumumab.
Кому может быть актуально: Состояния в реестре: Multiple Myeloma, Newly Diagnosed Multiple Myeloma. Базовые параметры: от 18 лет · Все.
Что важно проверить: Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
Где проводится: США, Аргентина, Австралия, Бельгия, Бразилия +19
Следующий шаг: Сохраните исследование, покажите его лечащему врачу и уточните актуальный статус у исследовательского центра. Расходы, документы и поездка →

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Официальное название

A Phase 3, Randomized, Open-label Study of Belantamab Mafodotin Administered in Combination With Lenalidomide and Dexamethasone (BRd) Versus Daratumumab, Lenalidomide, and Dexamethasone (DRd) in Participants With Newly Diagnosed Multiple Myeloma Who Are Ineligible for Autologous Stem Cell Transplantation (TI-NDMM)

Обзор

The purpose of this Phase 3 study is to evaluate if BRd prolongs progression free survival (PFS) and/or improves minimal residual disease (MRD) negative status compared with DRd in participants with TI-NDMM.

Вмешательства

Препарат Belantamab mafodotin
Belantamab mafodotin will be administered.
Препарат Lenalidomide
Lenalidomide will be administered.
Препарат Dexamethasone
Dexamethasone will be administered.
Препарат Daratumumab
Daratumumab will be administered.

Первичные конечные точки

PFS [Срок оценки: Up to approximately 7 years]
Number of Participants Achieving MRD Negative Status [Срок оценки: Up to approximately 7 years]

Вторичные конечные точки (12)

Overall Survival (OS) [Срок оценки: Up to approximately 7 years]
PFS2 [Срок оценки: Up to approximately 7 years]
Number of Participants Achieving CR or Better (CR+) [Срок оценки: Up to approximately 7 years]
Number of Participants Achieving Very Good Partial Response (VGPR) or Better [Срок оценки: Up to approximately 7 years]
Number of Participants Achieving Sustained MRD Negative Status [Срок оценки: Up to approximately 7 years]
Duration of Response (DoR) [Срок оценки: Up to approximately 7 years]
Time to Second Next Line Therapy (TTST) [Срок оценки: Up to approximately 7 years]
Number of Participants With Adverse Events (AEs) [Срок оценки: Up to approximately 7 years]
Number of Participants With Ocular Findings on Ophthalmic Exam [Срок оценки: Up to approximately 7 years]
Maximum Post-baseline Patient-Reported Outcomes Version of the Common Term Criteria for Adverse Events (PRO-CTCAE) Score [Срок оценки: Up to approximately 7 years]
Change From Baseline in European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ)-C30 [Срок оценки: Up to approximately 7 years]
Change From Baseline in EORTC QLQ-MY20 [Срок оценки: Up to approximately 7 years]

Критерии участия

Критерии включения

Is at least 18 or the legal age of consent in the jurisdiction in which the study is taking place, at the time of signing the informed consent.
Capable of giving signed informed consent, which includes compliance with the requirements and restrictions listed in the informed consent form and in the protocol.
NDMM with a requirement for treatment as documented per IMWG criteria.
Must have at least 1 aspect of measurable disease, as assessed by the central laboratory, defined as 1 of the following:

Urine M-protein excretion ≥200 mg/24 hours (≥0.2 g/24 hours) And/or
Serum M-protein concentration ≥0.5 g/dL (≥5.0 g/L) And/or
Serum free light-chain (FLC) assay: involved FLC level ≥10 mg/dL (≥100 mg/L) and an abnormal serum FLC ratio (<0.26 or >1.65).
Newly diagnosed and not considered candidate for high-dose chemotherapy with autologous stem cell transplant (ASCT) due to any of the following:

Exclusion from treatment with ASCT due to country- or site-specific age restriction.
Presence of comorbid condition(s) likely to have a negative impact on tolerability of high-dose chemotherapy with ASCT.
Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 2.
Adequate organ system function as defined by the laboratory assessments.
Male participants:

Contraceptive use by men should be consistent with local regulations regarding the methods of contraception for those participating in clinical studies.
Male participants are eligible to participate if they agree to the following during the Treatment Period and for at least 6 months after the last dose of study intervention to allow for clearance of any altered sperm:
Refrain from donating fresh unwashed semen

PLUS either:

Be abstinent from heterosexual intercourse as their preferred and usual lifestyle (abstinent on a long term and persistent basis) and agree to remain abstinent.

Must agree to use contraception/barrier as detailed below
Agree to use a male condom, even if they have undergone a successful vasectomy, and female partner to use an additional highly effective contraceptive method with a failure rate of <1% per year when having sexual intercourse with a woman of childbearing potential (WOCBP) who is not currently pregnant. Male participants should also use a condom when having sexual intercourse with pregnant females.
Female participants

Contraceptive use by women should be consistent with local regulations regarding the methods of contraception for those participating in clinical studies.
A female participant is eligible to participate if she is not pregnant or breastfeeding, and at least 1 of the following conditions applies:
Is not a WOCBP OR
Is a WOCBP and using a contraceptive method that is highly effective (with a failure rate of <1% per year), preferably with low user dependency during the Treatment Period and for 4 months after the last dose of study intervention and agrees not to donate eggs (ova, oocytes) for the purpose of reproduction during this period. The investigator should evaluate the effectiveness of the contraceptive method in relationship to the first dose of study intervention.
A WOCBP must have 2 negative highly sensitive serum pregnancy tests before starting treatment, the first may be performed within 14 days from C1D1, the second within 24 hours before the first dose of study intervention.
Should pregnancy occur in a female on treatment or the female partner of a male on treatment, treatment must be stopped, and it is advised to seek advice from a physician specialized or experienced in teratology.

Критерии исключения

Diagnosis of systemic amyloid light chain amyloidosis, Waldenstrom's disease, POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal plasma proliferative disorder, skin changes) or Primary Plasma Cell Leukemia (defined as circulating plasma cells >5%).
Prior systemic therapy for multiple myeloma, or smoldering multiple myeloma.
Signs of meningeal or central nervous system involvement with multiple myeloma.
Major surgery within 2 weeks prior to the first dose of study drugs or has not recovered fully from surgery. Kyphoplasty is not considered major surgery.
Any serious and/or unstable pre-existing medical, psychiatric disorder or other conditions (including lab abnormalities) that could interfere with participant's safety, obtaining informed consent, or compliance with study procedures.
Current active liver or biliary disease (except for Gilbert's syndrome or asymptomatic gallstones, or otherwise stable chronic liver disease as per the investigator's assessment).
Participants with previous or concurrent malignancies other than multiple myeloma are excluded. Exceptions are any other malignancy that has been considered medically stable for at least 2 years, after discussion with the GSK Medical Monitor. The participant must not be receiving active therapy, other than hormonal therapy for this disease.
Evidence of cardiovascular risk including any of the following:

Evidence of current clinically significant untreated arrhythmias, including clinically significant electrocardiogram abnormalities including second-degree (Mobitz Type II) or third-degree atrioventricular block.
Recent history (within 3 months of screening) of myocardial infarction, acute coronary syndromes (including unstable angina), coronary angioplasty or stenting, or bypass grafting.
Class III or IV heart failure as defined by the New York Heart Association functional classification system.
Known human immunodeficiency virus (HIV) infection, unless the participant can meet all of the following criteria:

Established antiretroviral therapy for at least 4 weeks and HIV viral load <400 copies/mL within Screening Period.
CD4+ T-cell (CD4+) counts ≥350 cells/μL.
No history of acquired immune deficiency syndrome-defining opportunistic infections within the last 12 months.
Positive hepatitis C antibody test result or positive hepatitis C ribonucleic acid (RNA) test result at screening or within 3 months prior to first dose of study intervention unless the participant can meet the following criteria:

RNA test negative.
Successful antiviral treatment (usually 8 weeks duration) is required, followed by a negative hepatitis C viral load RNA test after a washout period of at least 4 weeks.
Participants with hepatitis B will be excluded unless the defined criteria can be met.
Current corneal epithelial disease except for mild punctate keratopathy.
Intolerance or contraindications to antiviral prophylaxis.
Unable to tolerate antithrombotic prophylaxis.
Known immediate or delayed hypersensitivity reaction or idiosyncratic reaction to drugs chemically related to belantamab mafodotin, or any of the components of the study intervention.
Plasmapheresis within 7 days prior to the first dose of study intervention.
Participants must not have received a live or live-attenuated vaccine within 30 days prior to first dose of belantamab mafodotin.

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Нет

Дизайн исследования

Распределение: Рандомизированное
Модель: Параллельные группы
Маскирование: Открытое
Основная цель: Лечение