Gut-muscle Axis: Exploring the Gut Microbiota Influences Host Energy Sources and Exercise Performance

Официальное название

Gut-muscle Axis: Exploring the Gut Microbiota Influences Host Energy Sources and Exercise Performance Via Modulation of Lactate Metabolism and Utilization

Обзор

Through training, the investigators can adjust the composition and functions of gut microbiota. Exercise also alters the body's energy metabolism pathways, which, in turn, impacts the gut microbiota and its metabolic products. Understanding how the body utilizes and regulates energy during exercise is essential for enhancing athletic performance. This study aims to explore the relationships among post-exercise energy metabolites, gut microbiota, and their metabolic products, applying omics technologies in the field of sports science. This interdisciplinary research will contribute to fields such as exercise physiology, sports nutrition, exercise biochemistry, and sports medicine, providing innovative and practical research insights for advancing sports science in our country.

Подробное описание

The gut microbiota, which is comprised of trillions of microbes, is the collective term for the gut microbiota. It establishes a symbiotic relationship with the host and plays a vital role in maintaining host health. Through training, the investigators can adjust the composition and functions of gut microbiota. Exercise also alters the body's energy metabolism pathways, which, in turn, impacts the gut microbiota and its metabolic products. Understanding how the body utilizes and regulates energy during exercise is essential for enhancing athletic performance. This study aims to explore the relationships among post-exercise energy metabolites, gut microbiota, and their metabolic products, applying omics technologies in the field of sports science.

This interdisciplinary research will contribute to fields such as exercise physiology, sports nutrition, exercise biochemistry, and sports medicine, providing innovative and practical research insights for advancing sports science in our country.

Вмешательства

• Устройство running
  Running 10 kilometers on a treadmill

Первичные конечные точки

• Concentration of lactate [Срок оценки: The testing time points are set as follows: before exercise, at the 5-kilometer mark during exercise, immediately after exercise, and at 5, 15, 30, and 60 minutes post-exercise.]
• Concentration of creatine kinase [Срок оценки: The testing time points are set as follows: before exercise, immediately after exercise, and 60 minutes post-exercise.]
• Concentration of glucose [Срок оценки: The testing time points are set as follows: before exercise, immediately after exercise, and 60 minutes post-exercise.]
• Concentration of creatinine [Срок оценки: The testing time points are set as follows: before exercise, immediately after exercise, and 60 minutes post-exercise.]
• Concentration of blood urea nitrogen [Срок оценки: The testing time points are set as follows: before exercise, immediately after exercise, and 60 minutes post-exercise.]
• Concentration of lactate dehydrogenase [Срок оценки: The testing time points are set as follows: before exercise, immediately after exercise, and 60 minutes post-exercise.]
• Concentration of free fatty acid [Срок оценки: The testing time points are set as follows: before exercise, immediately after exercise, and 60 minutes post-exercise.]
• Concentration of cortisol [Срок оценки: The testing time points are set as follows: before exercise, immediately after exercise, and 60 minutes post-exercise.]
• ood frequency questionnaire(FFQ) [Срок оценки: Before exercise]
• Gut microbiota analysis [Срок оценки: The testing time points are set as follows: before exercise, immediately after exercise, and at 24 and 48 hours post-exercise.]

Вторичные конечные точки (3)

• Body composition [Срок оценки: Before exercise]
• Rate of Perceived Exertion(RPE) [Срок оценки: The testing time points are set as follows: before exercise, at the 5-kilometer mark during exercise, and immediately after exercise.]
• Heart rate [Срок оценки: The testing time points are set as follows: before exercise, at the 5-kilometer mark during exercise, and immediately after exercise.]

Критерии участия

Marathon Running Group

Критерии включения

• Training frequency of at least 3 times per week in the past year, with each session involving at least 1 hour of running.
• Participation in at least 2 marathon events within the past 2 years, with a completion time of under 4 hours and 30 minutes for a full marathon, or under 2 hours and 15 minutes for a half marathon.

Критерии исключения

• Excludes individuals with cardiovascular diseases, hypertension, epilepsy, bronchitis, severe asthma, heart disease, inflammatory bowel disease, bacterial or viral infections, disabilities, or chronic bone diseases.
• Habitual smokers.
• Individuals with highly irregular eating habits or sleep patterns due to shift work or night work.
• History of chronic neuro-muscular injuries or disorders in the past 6 months.
• Individuals who have received antibiotic treatment or taken probiotic supplements in the past 6 months.

General Healthy Adult Group

Критерии включения

• Generally healthy, untrained individuals.

Критерии исключения

• Excludes individuals with cardiovascular diseases, hypertension, epilepsy, bronchitis, severe asthma, heart disease, inflammatory bowel disease, bacterial or viral infections, disabilities, or chronic bone diseases.
• Habitual smokers.
• Individuals with highly irregular eating habits or sleep patterns due to shift work or night work.
• History of chronic neuro-muscular injuries or disorders in the past 6 months.
• Individuals who have received antibiotic treatment or taken probiotic supplements in the past 6 months.

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Да

Дизайн исследования

Распределение

Нерандомизированное

Модель

Параллельные группы

Маскирование

Открытое

Основная цель

Фундаментальное исследование

Центры проведения

Список центров уточняется — проверьте первичный протокол.

Идентификаторы

NCT: NCT06670742 · NTSUIRB - 112 - 007

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

Открыть это исследование на ClinicalTrials.gov ↗