The Effects of Exercise Intervention on Skeletal Muscle and Other Organs in Aged Population and the Discovery of Associated Circulating Biomarkers

Обзор

This project aims to investigate the intricate interplay between skeletal muscle and adipose tissue during the aging process by integrating human studies. Utilizing interventional research and randomized trials combined with examining blood samples from elderly individuals engaged in exercise, we aim to investigate the effects of exercise on muscle health and explore the underlying mechanisms of muscle aging and related biomarkers. Interdisciplinary research allowed us to investigate the systemic impact of exercise on muscles. This approach allowed us to gain a better understanding of the interconnectedness of skeletal muscle and adipose tissue in the aging process and devise efficient strategies to reverse age-related changes. These findings hold promise for promoting a future society where long and healthy life is achievable for all.

Подробное описание

This study is a randomized controlled trial of 6-month multidomain intervention program among community-living older adults with early physical impairments.

Inclusion criteria are: (1) community-dwelling adults aged ≥ 65 years, (2) slow gait speed (\<1 m/s in 6-meter walk test) or weakness (dominant handgrip strength \<28 kg in men, \<18 kg in women); subjects with the following conditions will be excluded: (1) established diagnosis of dementia, Parkinsonism or other neurodegenerative disease (2) disable status: mobilitylimiting conditions, (3) active, acute diseases receiving treatment, such as cancer, heart failure, COPD and so on, (4) estimated life expectancy \<12 months, (5) current nursing home residents.

Вмешательства

• Поведенческое Multi-domain intervention
  Each session comprises of 45 minutes physical fitness activities targeting on muscle strength, balance, and flexibility; 1-hour cognitive training primarily on reasoning and memory exercises; and 15-minute for nutritional advices based on national diet guidelines for older adults

Первичные конечные точки

• Change in Physical performance [Срок оценки: baseline, 6 month]

Вторичные конечные точки (10)

• Change in DHEA-S [Срок оценки: baseline, 6 month]
• Change in IGF-1 [Срок оценки: baseline, 6 month]
• Change in hs-CRP [Срок оценки: baseline, 6 month]
• Change in Myostatin [Срок оценки: baseline, 6 month]
• Change in Activing A [Срок оценки: baseline, 6 month]
• Change in Follistatin [Срок оценки: baseline, 6 month]
• Change in Relative appendicular skeletal muscle index (RASM) [Срок оценки: baseline, 6 month]
• Change in body fat % [Срок оценки: baseline, 6 month]
• Change in Cognitive performance [Срок оценки: baseline, 6 month]
• Change from lipoproflie [Срок оценки: baseline, 6 month]

Критерии участия

Критерии включения

• aged ≥ 65 years
• slow gait speed (<1 m/s in 6-meter walk test) or weakness (dominant handgrip strength <28 kg in men, <18 kg in women)

Критерии исключения

• established diagnosis of dementia, Parkinsonism or other mobility-limiting, disable conditions
• active, acute diseases receiving treatment, such as cancer, heart failure, COPD and so on
• estimated life expectancy <12 months
• current nursing home residents

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Нет

Дизайн исследования

Распределение

Рандомизированное

Модель

Параллельные группы

Маскирование

Открытое

Основная цель

Лечение

Центры проведения

Тайвань · 1 центр

• Center for Healthy Longevity and Aging Sciences, National Yang Ming Chiao Tung University — Taipei

Идентификаторы

NCT: NCT06660706 · NYCU112162AF

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

Открыть это исследование на ClinicalTrials.gov ↗