Development and Demonstration of Intelligent Assessment Based on Multi-modal Information Fusion for Tumor Risk and Diagnosis and Treatment

Обзор

To improve the accuracy of risk prediction, screening and treatment outcome of cancer, we aim to establish a medical database that includes standardized and structured clinical diagnosis and treatment information, image features, pathological features, and multi-omics information and to develop a multi-modal data fusion-based technology system using artificial intelligence technology based on database.

Подробное описание

The main aims are as follows:

1. To establish a data platform for multi-modal information of common tumors (lung cancer/pulmonary nodules, stomach and colorectal cancers) : electronic medical records (including routine clinical detection, treatment, outcome), pathological image data, medical imaging (CT, MRI, ultrasound, nuclear medicine, etc.), multiple omics data (genome, transcriptome, and metabolome, proteomics) omics data, etiology and carcinogenic exposure information. 2. We will make use of artificial intelligence technology to create the multi-modal medical big data cross-analysis technology and the above disease individualized accurate diagnosis and curative effect prediction models. In order to solve the three key problems of multi-modal data fusion mining, such as unbalanced, small sample size, and poor interpretability, we will establish an artificial intelligence recognition algorithm for image images and pathological images, and use image processing and deep learning technologies to mine multi-level depth visual features of image data and pathological data. In addition, we will use bioinformatics analysis algorithms to conduct molecular network mining and functional analysis of molecular markers at the level of multiple omics technologies (pathologic, genomic, transcriptome, metabolome, proteome, etc.).

Вмешательства

• Другое No Intervention
  No Intervention

Первичные конечные точки

• The outcome of clinical diagnosis of suspected patients with lung cancer/pulmonary nodular (Benign/Malignant nodule) [Срок оценки: 2022-2026]
• The outcome of clinical diagnosis of suspected patients with colorectal cancer or lesion (Benign/Malignant). [Срок оценки: 2022-2026]
• Treatment response of anti-cancer therapy at first evaluation in patients with lung/stomach/colorectal cancer (CR, PR, PD, SD). [Срок оценки: 2022-2026]

Критерии участия

Критерии включения

• Participants with the suspected of lung cancer/node, or stomach cancer/lesion, or colorectal cancer/leision
• Participants that have signed informed consent.
• Participants with detailed electronic medical records, image records, pathological records, multi-omics information, and other important clinical diagnostic information.
• Healthy participants with no clinical diagnosis of lung cancer/node, or stomach cancer/lesion, or colorectal cancer/leision.

Критерии исключения

• Participants with primary clinical and pathological data missing.
• Participants lost to follow-up.
• Participants with too poor medical image quality to perform segment and mark ROI accurately

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Да

Дизайн исследования

Модель наблюдения

Когортное

Центры проведения

Китай · 1 центр

• Wuhan Union Hospital — Ухань

Идентификаторы

NCT: NCT06653478 · Jin-BT&IT

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

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