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Идёт набор NCT06650969

China Diabetes Cognitive Dysfunction Early Diagnosis and Intervention Study (China-DECODE Study)

— Наблюдательное Type 2 Diabetes Subjective Cognitive Decline Mild Cognitive Impairment Dementia

Ориентир для пациента и семьи

Простыми словами

Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.

Что изучают
В протоколе указаны: Naturalistic observation.
Кому может быть актуально
Состояния в реестре: Type 2 Diabetes, Subjective Cognitive Decline, Mild Cognitive Impairment, Dementia. Базовые параметры: от 45 лет · Все.
Что важно проверить
Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
Где проводится
Китай
Следующий шаг
Сохраните исследование, покажите его лечащему врачу и уточните актуальный статус у исследовательского центра. Расходы, документы и поездка →

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Обзор

Type 2 diabetes (T2D) and dementia are both diseases with increasing incidence and prevalence globally, leading to substantial economic burdens for families and society. Notably, diabetes significantly increases the risk of cognitive dysfunction, which is classified into preclinical stage, mild cognitive impairment and dementia based on the disease severity. Cognitive dysfunction is a critical contributor to disability and mortality in elderly diabetes patients. Early diagnosis and intervention are crucial for delaying disease progression, enhancing treatment efficacy, and mitigating the impact of dementia. Currently, research and clinical management of cognitive dysfunction in individuals with diabetes are in their infancy, characterized by limitations such as single-center studies, limited sample sizes, inconsistent diagnostic criteria, and insufficient data sharing. Consequently, clinical diagnosis and treatment strategies are underdeveloped, medical staff's related knowledge is lacking, and potential therapeutic targets remain unexplored. In view of these problems and shortcomings, the population cohort study is supposed to be carried out based on accurate diagnosis and constructed the high standard information and sample bank. The study will establish the standard and quality system of T2D with cognitive dysfunction cohort study (unified standards and norms). The study will integrate the standard biological samples stratified acquisition function module (homogeneity and precision) of cognitive dysfunction in T2D, and complete the construction of biological samples bank and clinical diagnosis and treatment information database. The study will apply and develop brain structural and functional imaging technology to support precision diagnosis of cognitive dysfunction in T2D.

Подробное описание

The neuropsychological test battery are used to access the cognitive function of subjects in the study. The laboratory examinations, brain MRI and olfactory function measurements will be done in the screening period. The samples such as plasma, serum, urine and faeces et al. of the subjects will be collected in the study.

Вмешательства

  • Другое Naturalistic observation
    Naturalistic observation

Первичные конечные точки

  • Prevalence, incidence of cognitive dysfunction in type 2 diabetes [Срок оценки: From 2016 to 2034]
  • Risk factors for cognitive dysfunction in type 2 diabetes, such as diabetes duration, poor glycemic control, hypertension, obesity, dyslipidemia, and active inflammation, et al. [Срок оценки: From 2016 to 2034]
  • Biomarkers of cognitive dysfunction in type 2 diabetes [Срок оценки: From 2016 to 2034]
  • Glycemic control targets for cognitive dysfunction in type 2 diabetes [Срок оценки: From 2016 to 2034]

Критерии участия

Критерии включения

  • Age ≥45 years;
  • Type 2 diabetes diagnosed according to the American Diabetes Association criteria;
  • Willingness and ability to complete systematic neuropsychological tests;
  • Understanding of the research procedures and methods, potential benefits and risks of the trial, and sign written informed consent.

Критерии исключения

  • Fewer than 6 years of education;
  • Left-handedness;
  • Dementia;
  • Acute metabolic complications such as diabetic ketoacidosis, hyperglycaemic hyperosmolar state and hypoglycaemic coma within the previous 3 months;
  • History or presence of neurological or psychiatric disorders;
  • Presence of hypothyroidism;
  • History of malignancy, or severe kidney or liver dysfunction.

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Да

Дизайн исследования

Модель наблюдения
Когортное

Центры проведения

Китай · 1 центр
  • Department of Endocrinology, Endocrine and Metabolic Disease Medical Center, Nanjing Drum — Нанкин

Идентификаторы

NCT: NCT06650969 · DECODE2024

Первоисточники (государственные реестры)

Открыть это исследование на ClinicalTrials.gov ↗