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Идёт набор NCT06646432

Treatment of Gingival Recession With Tunnel Technique Using Connective Tissue Graft and Injectable Platelet Rich Fibrin

Без фазы С лечением Gingival Recession

Ориентир для пациента и семьи

Простыми словами

Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.

Что изучают
В протоколе указаны: Tunnel with connective tissue graft and injectable platelet rich fibrin, Tunnel with connective tissue graft only.
Кому может быть актуально
Состояния в реестре: Gingival Recession. Базовые параметры: от 21 лет · Все.
Что важно проверить
Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
Где проводится
Египет
Следующий шаг
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Официальное название

Treatment of Gingival Recession by Tunnel Technique Using Connective Tissue Graft With or Without Injectable Platelet Rich Fibrin: A Randomized Controlled Clinical Trial

Обзор

Gingival recession is a common periodontal problem. Consequences include teeth sensitivity, poor esthetics and impaired oral hygiene access. Mild cases are managed by optimizing oral hygiene measures, correction of any causative factor such as faulty tooth brushing, improper dental restoration or denture clasp. Prescription of desensitization products such as specific tooth gels or mouth washes can manage the sensitivity problem. Deeper recession defects need to be addressed by surgical procedures. Coronally advanced flap with connective tissue graft is the gold standard procedure. However, it has some drawbacks due to the need for papillary incisions and vertical incisions in some cases. Within the era of minimally invasive periodontology, tunnel technique with connective tissue graft showed results comparable to coronally advanced flap with connective tissue graft but with some limitations. Addition of another agent may enhance the results of tunnel technique. Injectable platelet rich fibrin is known for its content of growth factors and effects on soft tissue healing. Aim: The study aim is to compare the surgical management of gingival recession with tunnel technique using connective tissue graft and injectable platelet rich fibrin to tunnel with connective graft without injectable platelet rich fibrin. Methodology: 30 patients with miller class I or II gingival recession will be enrolled. 15 in the test group (Tunnel+ CTG+ i-PRF) and 15 in control group (Tunnel+ CTG). Clinical evaluation at 6 months

Подробное описание

30 patients with miller class I/II gingival recession will be enrolled in this study.

15 patients will be treated using tunnel technique and palatal connective tissue graft inserted and sutured under the prepared tunnel after being soaked in injectable platelet rich fibrin for 15 minutes. The tunnel with the underlying graft will be advanced coronally. (Test Group) The other 15 patients will be treated the same way as in the first group but without soaking the graft in injectable platelet rich fibrin. (Control Group) Clinical parameters will be evaluated at baseline and 6 months follow-up except post-operative pain which will be assessed after 10 days. Histologic examination of small piece of the graft will be done to assess if there is true saturation of growth factors inside the graft.

Вмешательства

  • Процедура Tunnel with connective tissue graft and injectable platelet rich fibrin
    Tunnel with connective tissue graft and injectable platelet rich fibrin
  • Процедура Tunnel with connective tissue graft only
    Tunnel technique with connective tossue graft only without injectable platelet rich fibrin

Первичные конечные точки

  • Recession depth [Срок оценки: 6 months after the surgery]
  • Keratinized tissue height [Срок оценки: 6 months]
  • Gingival thickness [Срок оценки: 6 months]
Вторичные конечные точки (2)
  • Post operative pain [Срок оценки: 10 days]
  • Recession width [Срок оценки: 6 months]

Критерии участия

Критерии включения

  • More than 21 years old
  • Systemically healthy
  • Presence of Miller class I/II gingival recession
  • Presence of identifiable CEJ

Критерии исключения

  • Smoking
  • Systemic disease that contraindicates surgical procedures.
  • Poor compliance with oral hygiene measures
  • Necrotizing gingival conditions
  • Ongoing active periodontitis

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Нет

Дизайн исследования

Распределение
Рандомизированное
Модель
Параллельные группы
Маскирование
Простое слепое
Основная цель
Лечение

Центры проведения

Египет · 1 центр
  • Faculty of dentistry, Suez canal university — Ismailia

Публикации

  • Mahmoud MNA, Elrefaei AMH, Shata MS, Rokaya D, Morsy SM. Connective tissue graft with injectable platelet rich fibrin for treatment of RT1 gingival recession by tunnel technique: a randomized clinical and immunohistochemical study. Front Oral Health. 2026 Jun 10;7:1801423. doi: 10.3389/froh.2026.1801423. eCollection 2026. PMID 42359019

Идентификаторы

NCT: NCT06646432 · 486/2022

Первоисточники (государственные реестры)

Открыть это исследование на ClinicalTrials.gov ↗