Идёт набор NCT06645405

AI-Driven CTA Reconstruction for Intracranial LVO

Без фазы С лечением Acute Ischemic Stroke Artificial Intelligence (AI) Endovascular Thrombectomy CT Angiography

Ориентир для пациента и семьи

Простыми словами

Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.

Что изучают: В протоколе указаны: AI algorithm.
Кому может быть актуально: Состояния в реестре: Acute Ischemic Stroke, Artificial Intelligence (AI), Endovascular Thrombectomy, CT Angiography. Базовые параметры: 18 лет — 95 лет · Все.
Что важно проверить: Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
Где проводится: Китай
Следующий шаг: Сохраните исследование, покажите его лечащему врачу и уточните актуальный статус у исследовательского центра. Расходы, документы и поездка →

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Официальное название

Segmentation and Modeling for Accurate Reconstruction of CT Angiography of Intracranial Large Vessel Occlusion with Artificial Intelligence: a Stepped-wedge, Cluster-randomized Controlled Trial

Обзор

Acute ischemic stroke (AIS) caused by intracranial large vessel occlusion (LVO) in the anterior circulation significantly contributes to stroke-related disability and mortality. Recent randomized controlled trials have demonstrated substantial benefits of endovascular thrombectomy (EVT) when patients are appropriately triaged beforehand. However, accurately orienting the 'missed segment' during EVT remains challenging. Guide-wires often fail to navigate through the occlusion or are mistakenly directed into the small tranches or even cause vessel rupture. To address this clinical need, the investigators developed an artificial intelligence (AI) algorithm to automate the reconstruction of CT angiography (CTA), focusing on the occluded LVO segment. To evaluate the clinical utility of this AI algorithm, the investigators propose a prospective, stepped-wedge cluster-randomized study to determine whether integrating our AI algorithm into AIS care flow can reduce the time for first pass of the thrombus by improving the visualization of the occluded segment on CTA. Physicians will assess patient eligibility for thrombectomy, and all selected patients will receive standard care according to current guidelines. This approach is expected to enhance patient treatment outcomes for endovascular thrombectomy by leveraging readily available data.

Вмешательства

Поведенческое AI algorithm
Artificial intelligence algorithms in the automated reconstruction of intracranial large vessel occlusion (LVO)

Первичные конечные точки

AFAT [Срок оценки: Immediately after EVT]

Вторичные конечные точки (8)

PRT [Срок оценки: Immediately after EVT]
IPT [Срок оценки: Immediately after EVT]
IRT [Срок оценки: Immediately after EVT]
The rate of successful flow restoration immediately after EVT [Срок оценки: Immediately after EVT]
The rate of symptomatic intracerebral hemorrhage within 24 hours post-EVT [Срок оценки: 24 hours post-EVT]
The rate of procedure-related complications [Срок оценки: Immediately after EVT]
The rate of functional independence at 90 days post-EVT [Срок оценки: 90 days post-EVT]
The mortality rate within 90 days post-EVT [Срок оценки: 90 days post-EVT]

Критерии участия

Критерии включения

Male or Female, 18 years of age or older.
Patients who present with signs and/or symptoms concerning acute ischemic stroke.
Patients who undergo noncontrast CT and CT angiography imaging.
Patients determined to have an intracranial large vessel occlusion (including the internal carotid artery, middle cerebral artery M1 segment, and M2 segment), and eligible for endovascular treatment.